(Q35182894)

English

FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2 (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

G protein-coupled receptor

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transmembrane protein

0 references

fingolimod hydrochloride

1 reference

ChEBI release 2020-05-28

author name string

William J Valentine

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Virginia I Godwin

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Daniel A Osborne

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Jianxiong Liu

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Yuko Fujiwara

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

James Van Brocklyn

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Robert Bittman

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Abby L Parrill

8

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Gabor Tigyi

9

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

0 references

publication date

30 June 2011

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

30513-30525

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Therapeutic potential of β-arrestin- and G protein-biased agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Extracellular and intracellular actions of sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Regulation of vascular physiology and pathology by the S1P2 receptor subtype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Molecular recognition in the sphingosine 1-phosphate receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Gene splicing and mutagenesis by PCR-driven overlap extension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Identification of the hydrophobic ligand binding pocket of the S1P1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162411

13 July 2018

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.263442

21 January 2018

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.263442

21 January 2018

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.263442

21 January 2018

Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.263442

21 January 2018

Identifiers

10.1074/JBC.M111.263442

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

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