(Q35183154)

7 August 2017

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title

Regulation of IL4 gene expression by T cells and therapeutic perspectives (English)

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7 August 2017

Min Li-Weber

1

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7 August 2017

Peter H Krammer

series ordinal

2

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7 August 2017

language of work or name

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1 July 2003

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Nature Reviews Immunology

7 August 2017

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7 August 2017

3

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7 August 2017

7

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7 August 2017

534-543

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https://scigraph.springernature.com/pub.10.1038/nri1128

7 August 2017

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The lineage decisions of helper T cells

21 January 2018

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

21 January 2018

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

21 January 2018

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

21 January 2018

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

21 January 2018

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

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A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

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The role of the mast cell in asthma: a reassessment

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

21 January 2018

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Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

21 January 2018

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

21 January 2018

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Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement

21 January 2018

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Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

21 January 2018

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Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

21 January 2018

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Cytokines and autoimmunity

21 January 2018

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IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice.

21 January 2018

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Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists

21 January 2018

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21 January 2018

IL-13 effector functions

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IgE-dependent mast cell activation potentiates airway responses in murine asthma models

21 January 2018

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Regulation of mast-cell and basophil function and survival by IgE.

21 January 2018

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Role of chemokines in the pathogenesis of asthma

21 January 2018

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

21 January 2018

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GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

21 January 2018

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Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

21 January 2018

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Transcription factors of the NFAT family: regulation and function

21 January 2018

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Partners in transcription: NFAT and AP-1.

21 January 2018

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An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals

21 January 2018

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Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

21 January 2018

1 reference

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

21 January 2018

1 reference

Characterization of P5, a novel NFAT/AP-1 site in the human IL-4 promoter.

21 January 2018

1 reference

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

21 January 2018

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An enhanced immune response in mice lacking the transcription factor NFAT1.

21 January 2018

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Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

21 January 2018

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Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

21 January 2018

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NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

21 January 2018

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

1 reference

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

21 January 2018

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Protein kinase C(theta) in T cell activation

21 January 2018

1 reference

Protein kinase C-theta;: signaling from the center of the T-cell synapse

21 January 2018

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Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

21 January 2018

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Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.

21 January 2018

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Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

21 January 2018

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Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

21 January 2018

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JNK is required for effector T-cell function but not for T-cell activation

21 January 2018

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FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells

21 January 2018

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Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells

21 January 2018

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Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.

21 January 2018

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Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

21 January 2018

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CCAAT/enhancer-binding proteins: structure, function and regulation

21 January 2018

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A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6

21 January 2018

1 reference

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor

21 January 2018

1 reference

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction

21 January 2018

1 reference

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

21 January 2018

1 reference

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

21 January 2018

1 reference

Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter

21 January 2018

1 reference

C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells.

21 January 2018

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IRF-4 activities in HTLV-I-induced T cell leukemogenesis

21 January 2018

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IRF family of transcription factors as regulators of host defense

21 January 2018

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Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).

21 January 2018

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A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes

21 January 2018

1 reference

Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.

21 January 2018

1 reference

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

21 January 2018

1 reference

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

21 January 2018

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Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter

21 January 2018

1 reference

Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein

21 January 2018

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Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?

21 January 2018

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Yin-Yang 1 activates interleukin-4 gene expression in T cells.

21 January 2018

1 reference

21 January 2018

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

21 January 2018

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Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells

21 January 2018

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MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300.

21 January 2018

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The transcription factor NFAT4 is involved in the generation and survival of T cells

21 January 2018

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Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells.

21 January 2018

1 reference

HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells

21 January 2018

1 reference

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

21 January 2018

1 reference

JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

1 reference

The mechanism of action of cyclosporin A and FK506

21 January 2018

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Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation.

21 January 2018

1 reference

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

21 January 2018

1 reference

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

21 January 2018

1 reference

21 January 2018

Vitamin E and immunity

1 reference

Elevated IgE level in relationship to nutritional status and immune parameters in early human immunodeficiency virus-1 disease

21 January 2018

1 reference

Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS.

21 January 2018

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Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

21 January 2018

1 reference

Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression

21 January 2018

1 reference

Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1.

21 January 2018

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NF-kappaB as a primary regulator of the stress response

21 January 2018

1 reference

Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity

21 January 2018

1 reference

Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults

21 January 2018

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Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

21 January 2018

1 reference

NF-kappaB: a key role in inflammatory diseases

21 January 2018

1 reference

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

21 January 2018

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The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.

21 January 2018

1 reference

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

21 January 2018

1 reference

Inhibition of NF-kappa B by sodium salicylate and aspirin

21 January 2018

1 reference

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

1 reference

Inhibition of activator protein 1 activity and neoplastic transformation by aspirin

21 January 2018

1 reference

Selective inhibition of interleukin-4 gene expression in human T cells by aspirin

21 January 2018

1 reference

Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy?

21 January 2018

1 reference

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

21 January 2018

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Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization

21 January 2018

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c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.

21 January 2018

1 reference

Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

21 January 2018

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

31 March 2020

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IFN-gamma represses IL-4 expression via IRF-1 and IRF-2

31 March 2020

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Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

31 March 2020

1 reference

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production

31 March 2020

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Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster

31 March 2020

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Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

31 March 2020

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Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

31 March 2020

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Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

31 March 2020

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Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

31 March 2020

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NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines

31 March 2020

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NFATc1 and NFATc2 together control both T and B cell activation and differentiation

31 March 2020

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Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins

31 March 2020

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Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter

31 March 2020

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Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

31 March 2020

1 reference

Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells

31 March 2020

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Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo

31 March 2020

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A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

31 March 2020

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Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

31 March 2020

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Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

31 March 2020

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A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production

31 March 2020

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Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

31 March 2020

1 reference

Dietary vitamin E, IgE concentrations, and atopy

31 March 2020

1 reference

Nutritional status and immune responses in mice with murine AIDS are normalized by vitamin E supplementation

31 March 2020

1 reference

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta

31 March 2020

1 reference

The Interleukin-4-Receptor: From Recognition Mechanism to Pharmacological Target Structure

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1128

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Dimensions Publication ID

7 August 2017

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