(Q35183631)

English

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

monoclonal antibody

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Zhenhua Xu

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Esther Bouman-Thio

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Craig Comisar

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Bart Frederick

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Bart Van Hartingsveldt

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Joseph C Marini

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Hugh M Davis

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Honghui Zhou

8

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

0 references

publication date

1 August 2011

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

72

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

270-281

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Population pharmacokinetics of infliximab in patients with ankylosing spondylitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Elimination mechanisms of therapeutic monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Interleukin-6: from basic science to medicine--40 years in immunology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Adipocytokines and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

The role of C-reactive protein as a prognostic indicator in advanced cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical symptoms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

The evidence for interleukin-6 as an autocrine growth factor in malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

28 July 2018

Population pharmacokinetic analysis of tocilizumab in patients with rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Fixed dosing versus body size-based dosing of monoclonal antibodies in adult clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Extensions to the visual predictive check to facilitate model performance evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

The role of IL-6 and STAT3 in inflammation and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Model appropriateness and population pharmacokinetic modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3162657

27 September 2018

Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: A randomized, double-blind, placebo-controlled, dose-ranging study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.03964.X

21 January 2018

Serum interleukin-6 in relation to acute-phase reactants and survival in patients with renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.03964.X

21 January 2018

Population pharmacokinetics of rituximab (anti-CD20 monoclonal antibody) in rheumatoid arthritis patients during a phase II clinical trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/21392075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular properties of a factor inducing differentiation in murine myelomonocytic leukemic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21392075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21392075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of serum C-reactive protein in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21392075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/21392075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2011.03964.X

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

ResearchGate publication ID

0 references

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