(Q35184175)

7 August 2017

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title

A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses (English)

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7 August 2017

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Kamran Ghoreschi

1

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PubMed ID

12879154

7 August 2017

Ulrich Mrowietz

series ordinal

2

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PubMed ID

12879154

7 August 2017

Martin Röcken

series ordinal

3

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7 August 2017

18 July 2003

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Journal of Molecular Medicine

7 August 2017

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7 August 2017

81

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7 August 2017

8

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7 August 2017

471-480

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https://scigraph.springernature.com/pub.10.1007/s00109-003-0460-9

7 August 2017

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Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells.

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12 December 2020

Beneficial effects of fumarate therapy in psoriasis vulgaris patients coincide with downregulation of type 1 cytokines

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12 December 2020

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A novel immunosuppressive 1alpha,25-dihydroxyvitamin D3 analog with reduced hypercalcemic activity

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12 December 2020

Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-gamma and IL-4 expression in psoriatic skin in situ

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12 December 2020

Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s

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12 December 2020

Low-dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nail, and joint involvement

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12 December 2020

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12 December 2020

IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach

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12 December 2020

Safety and efficacy of oral calcitriol (1,25-dihydroxyvitamin D3) for the treatment of psoriasis

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12 December 2020

Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference

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12 December 2020

Role of increased production of monocytes TNF-alpha, IL-1beta and IL-6 in psoriasis: relation to focal infection, disease activity and responses to treatments

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12 December 2020

Calcipotriene-induced improvement in psoriasis is associated with reduced interleukin-8 and increased interleukin-10 levels within lesions

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12 December 2020

Fumaric acid esters are potent immunosuppressants: inhibition of acute and chronic rejection in rat kidney transplantation models by methyl hydrogen fumarate

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12 December 2020

Immunomodulation by interleukin-10 therapy decreases the incidence of relapse and prolongs the relapse-free interval in Psoriasis.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

1,25-Dihydroxyvitamin D(3) inhibits dendritic cell differentiation and maturation in vitro

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB

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12 December 2020

1alpha,25-dihydroxycholecalciferol and cyclosporine suppress induction and promote resolution of psoriasis in human skin grafts transplanted on to SCID mice

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12 December 2020

Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate

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12 December 2020

Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis

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12 December 2020

Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells

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12 December 2020

Development of psoriasis after syngeneic bone marrow transplant from psoriatic donor: further evidence for adoptive autoimmunity

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12 December 2020

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

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12 December 2020

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice

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12 December 2020

Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.

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12 December 2020

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial

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12 December 2020

Exposure to ultraviolet radiation causes dendritic cells/macrophages to secrete immune-suppressive IL-12p40 homodimers

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12 December 2020

Psoriasis vulgaris--a sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis

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12 December 2020

The lineage decisions of helper T cells

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12 December 2020

Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.

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12 December 2020

Remission of psoriatic lesions with muromonab-CD3 (orthoclone OKT3) treatment

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12 December 2020

Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level

1 reference

12 December 2020

The IL-10-producing competence of Th2 cells generated in vitro is IL-4 dependent

1 reference

12 December 2020

Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production

1 reference

12 December 2020

Suppression of collagen-induced arthritis by continuous administration of IL-4.

1 reference

12 December 2020

Role of epidermal cell-derived alpha-melanocyte stimulating hormone in ultraviolet light mediated local immunosuppression

1 reference

12 December 2020

Emerging role of anti-tumor necrosis factor therapy in rheumatic diseases

1 reference

12 December 2020

Efficacy of cyclosporin A in psoriasis: a summary of the United States' experience

1 reference

12 December 2020

1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.

1 reference

12 December 2020

Treatment of psoriasis with interleukin-10

1 reference

12 December 2020

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

1 reference

12 December 2020

Methotrexate and other chemotherapeutic agents used to treat psoriasis.

1 reference

12 December 2020

Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis?

1 reference

12 December 2020

Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

1 reference

12 December 2020

Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis

1 reference

12 December 2020

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1 reference

12 December 2020

Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.

1 reference

12 December 2020

Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients

1 reference

12 December 2020

Influence of longterm therapy with methotrexate and low dose corticosteroids on type 1 and type 2 cytokine production in CD4+ and CD8+ T lymphocytes of patients with rheumatoid arthritis

1 reference

12 December 2020

IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function

1 reference

12 December 2020

Interleukin-11 induces Th2 polarization of human CD4(+) T cells

1 reference

12 December 2020

Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain

1 reference

12 December 2020

Identification of C5ades arg and an anionic neutrophil-activating peptide (ANAP) in psoriatic scales

1 reference

12 December 2020

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1 reference

12 December 2020

Treatment with anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions

1 reference

12 December 2020

Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets

1 reference

12 December 2020

Phototherapy for psoriasis

1 reference

12 December 2020

Infection breaks T-cell tolerance.

1 reference

12 December 2020

Promoter Polymorphisms of the Genes Encoding Tumor Necrosis Factor-α and Interleukin-1β are Associated with Different Subtypes of Psoriasis Characterized by Early and Late Disease Onset

1 reference

12 December 2020

Treatment of psoriasis with fumaric acid esters: results of a prospective multicentre study. German Multicentre Study

1 reference

12 December 2020

Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway

1 reference

12 December 2020

Narrow-band UVB (311 nm) versus conventional broad-band UVB with and without dithranol in phototherapy for psoriasis

1 reference

12 December 2020

The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiat

1 reference

12 December 2020

Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro

1 reference

12 December 2020

1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543)

1 reference

12 December 2020

Psoriasis--epidemiology and clinical spectrum

1 reference

12 December 2020

Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment

1 reference

12 December 2020

Retinoic acid promotes the development of Th2-like human myelin basic protein-reactive T cells

1 reference

12 December 2020

Murine psoriasis-like disorder induced by naive CD4+ T cells.

1 reference

12 December 2020

Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations

1 reference

12 December 2020

Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris

1 reference

12 December 2020

Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology.

1 reference

12 December 2020

The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody

1 reference

12 December 2020

Psoriasis as a model for T-cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody.

1 reference

12 December 2020

10.1007/S00109-003-0460-9

Identifiers

DOI

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7 August 2017

1 reference

PubMed ID

12879154