(Q35186641)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12885262%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Bone as an effect compartment : models for uptake and release of drugs (English)

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6 November 2019

1

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6 November 2019

author name string

Lilach Kleinberg

series ordinal

2

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6 November 2019

Amnon Hoffman

series ordinal

3

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6 November 2019

publication date

1 January 2003

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Clinical Pharmacokinetics

6 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12885262%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

volume

42

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12885262%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

issue

10

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6 November 2019

page(s)

863-881

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Pharmacokinetics of fluoride in man after single and multiple oral doses

6 November 2019

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Fluoride salts are no better at preventing new vertebral fractures than calcium-vitamin D in postmenopausal osteoporosis: the FAVOStudy

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Targeted radionuclide therapy for bone metastases.

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Pharmacokinetics of alendronate

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A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm

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Long-term predictions of the therapeutic equivalence of daily and less than daily alendronate dosing

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Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models

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Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group

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Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate

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12 December 2020

Bisphosphonates: a review of their pharmacokinetic properties

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12 December 2020

Response of cortical bone to local controlled release of sodium fluoride: the effect of implant insertion site

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12 December 2020

Clinical trial of fluoride therapy in postmenopausal osteoporotic women: extended observations and additional analysis

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12 December 2020

Physiologically based models for bone-seeking elements. IV. Kinetics of lead disposition in humans

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Incorporation and distribution of strontium in bone

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Pharmacodynamic aspects of modes of drug administration for optimization of drug therapy

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12 December 2020

The ICRP age-specific biokinetic model for lead: validations, empirical comparisons, and explorations

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12 December 2020

Analysis of whole skeleton 3H-tetracycline loss as a measure of bone resorption in maturing rats

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12 December 2020

Fluorescence of tetracycline antibiotics in bone

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12 December 2020

Lead in bone: implications for toxicology during pregnancy and lactation

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12 December 2020

A systemic biokinetic model for polonium

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12 December 2020

Biochemical and autoradiographic evaluation of bone turnover in prelabeled dogs and rabbits on normal and calcium-deficient diets

1 reference

12 December 2020

Antimicrobial treatment of chronic osteomyelitis.

1 reference

12 December 2020

A biokinetic model for lead metabolism with a view to its extension to pregnancy and lactation; (1). Further validation of the original model for non-pregnant adults

1 reference

12 December 2020

Studies of skeletal tracer kinetics. I. Digital-computer solution of a five-compartment model of [18F] fluoride kinetics in humans

1 reference

12 December 2020

Fetal rat bone in organ culture: effect of bone growth and bone atrophy on the comparative losses of 45Ca and 3H-tetracycline

1 reference

12 December 2020

Evaluation and modification of a physiologically based model of lead kinetics using data from a sequential isotope study in cynomolgus monkeys

1 reference

12 December 2020

Different patterns of global and regional skeletal uptake of 99mTc-methylene diphosphonate with age: relevance to the pathogenesis of bone loss

1 reference

12 December 2020

A pharmacokinetic model in the rat and rabbit of the direct measurement of mature bone resorption in vivo with [3H]tetracycline

1 reference

12 December 2020

Comparison of growth-induced resorption and denervation-induced resorption on the release of [3H]tetracycline, 45calcium, and [3H]collagen from whole bones of growing rats

1 reference

12 December 2020

The re-incorporation in calcified tissues of tetracycline released following its deposition in the bone of rats

1 reference

12 December 2020

Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms

1 reference

12 December 2020

The pharmacokinetics and distribution of pamidronate for a range of doses in the mouse

1 reference

12 December 2020

The development of a stochastic physiologically-based pharmacokinetic model for lead

1 reference

12 December 2020

Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood

1 reference

12 December 2020

A mathematical model for fluoride uptake by the skeleton.

1 reference

12 December 2020

Tetracyclines and fetal bones

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12 December 2020

Carrier systems for the local delivery of antibiotics in bone infections

1 reference

12 December 2020

Strategies for epidemiologic studies of lead in bone in occupationally exposed populations

1 reference

12 December 2020

Mechanisms of action of bisphosphonates

1 reference

12 December 2020

Association between pharmacokinetics of oral ibandronate and clinical response in bone mass and bone turnover in women with postmenopausal osteoporosis

1 reference

12 December 2020

Measurement of serum [3H]tetracycline kinetics and indices of kidney function facilitate study of the activity and toxic effects of bisphosphonates in bone resorption

1 reference

12 December 2020

Strontium-89: treatment results and kinetics in patients with painful metastatic prostate and breast cancer in bone.

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic evaluation of intermittent versus continuous alendronate administration in rats

1 reference

12 December 2020

Penetration of cefazolin into normal and osteomyelitic canine cortical bone

1 reference

12 December 2020

Pharmacokinetics of cefamandole in osseous tissue

1 reference

12 December 2020

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

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12 December 2020

Role of pharmacokinetics and metabolism in drug discovery and development

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12 December 2020

The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation.

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12 December 2020

Pharmacokinetics: philosophy of modeling.

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12 December 2020

Physiologically based models of metal kinetics

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12 December 2020

Bone turnover and biochemical markers in malignancy

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12 December 2020

Toxicokinetics of bone lead

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12 December 2020

Targeted delivery of antineoplastic agent to bone: biodistribution studies of technetium-99m-labeled gem-bisphosphonate conjugate of methotrexate

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12 December 2020

Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases

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12 December 2020

Intravenous zoledronic acid in postmenopausal women with low bone mineral density

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12 December 2020

Intake and metabolism of fluoride

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12 December 2020

Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties

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12 December 2020

A physiologically based pharmacokinetic model for fluoride uptake by bone.

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12 December 2020

Fluoride concentrations in human and rat bone

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12 December 2020

Whole body autoradiography and fluorography of two tetracycline compounds in tumour-bearing mice

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12 December 2020

Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate

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12 December 2020

Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis

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12 December 2020

Fluoride: mode of action

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12 December 2020

Bisphosphonates: from the laboratory to the clinic and back again

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12 December 2020

Anticancer activity of bisphosphonic acids in methylnitrosourea-induced mammary carcinoma of the rat--benefit of combining bisphosphonates with cytostatic agents.

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12 December 2020

A theoretical analysis of the contributions of remodeling space, mineralization, and bone balance to changes in bone mineral density during alendronate treatment.

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12 December 2020

An age-specific kinetic model of lead metabolism in humans

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12 December 2020

Effect of controlled local release of sodium fluoride on trabecular bone.

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12 December 2020

Skeletal drug delivery systems

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12 December 2020

Diagnosis and management of osteomyelitis.

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12 December 2020

Current status in oral fluoride pharmacokinetics and implications for the prophylaxis against dental caries

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12 December 2020

A model for local accumulation of bone imaging radiopharmaceuticals.

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12 December 2020

Uptake of alendronate by bone tissue in hypocalcemic and hypercalcemic rats.

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12 December 2020

Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS).

1 reference

12 December 2020

Skeletal uptake and soft-tissue retention of 186Re-HEDP and 153Sm-EDTMP in patients with metastatic bone disease.

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12 December 2020

Penetration of ciprofloxacin into bone: a new bioabsorbable implant

1 reference

12 December 2020

Markers of bone turnover for monitoring treatment of osteoporosis with antiresorptive drugs

1 reference

12 December 2020

Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats

1 reference

12 December 2020

A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone

1 reference

12 December 2020

Metabolism of tetracycline in the rat and the dog

1 reference

12 December 2020

Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations

1 reference

12 December 2020

Fluoride metabolism and excretion in children

1 reference

12 December 2020

Variation of resorption rates in vivo of various bones in immature rats

1 reference

12 December 2020

1 reference

12 December 2020

The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration

1 reference

12 December 2020

An implantable dosage form for the treatment of bone infections

1 reference

12 December 2020

A physiologically based model of chromium kinetics in the rat

1 reference

12 December 2020

Cisplatin-linked phosphonates in the treatment of the transplantable osteosarcoma in vitro and in vivo

1 reference

12 December 2020

Distribution of clodronate in the bone of adult rats and its effects on trabecular and cortical bone

1 reference

12 December 2020

Ipriflavone inhibits bone resorption in intact and ovariectomized rats

1 reference

12 December 2020

Extraskeletal localization of 99mTc-labeled bone-seeking tracers in bone scintigraphy

1 reference

12 December 2020

Bone: target and source of environmental pollutant exposure

1 reference

12 December 2020

99Tcm-citrate: a new bone imaging radiopharmaceutical

1 reference

12 December 2020

Recent advances in bone marrow scanning

1 reference

12 December 2020

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. V. Biological disposition and targeting characteristics of osteotropic estradiol

1 reference

12 December 2020

BM 21.0955, a potent new bisphosphonate to inhibit bone resorption

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12 December 2020

Studies of skeletal tracer kinetics: II. evaluation of a five-compartment model of [18F]fluoride kinetics in rats

1 reference

12 December 2020

Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?

1 reference

12 December 2020

Pharmacometrics: modelling and simulation tools to improve decision making in clinical drug development.

1 reference

12 December 2020

Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake.

1 reference

12 December 2020

Uptake and biodistribution of technetium-99m-MD32P during rat tibial bone repair

1 reference

12 December 2020

Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

1 reference

12 December 2020

Assay of bone resorption in vivo with 3H-tetracycline

1 reference

12 December 2020

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

1 reference

12 December 2020

Concurrent exchange of 45Ca and 3H-tetracycline from rat bone in vitro

1 reference

12 December 2020

Lead in bone: storage site, exposure source, and target organ

1 reference

12 December 2020

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I: synthesis and in vivo characterization of osteotropic carboxyfluorescein

1 reference

12 December 2020

Radionuclide-targeted therapy for the management of metastatic bone pain.

1 reference

12 December 2020

Biochemical markers to survey bone turnover

1 reference

12 December 2020

Influence of Lead on Mineralization during Bone Growth

1 reference

12 December 2020

Effect of bisphosphonates on the increase in bone resorption induced by a low calcium diet

1 reference

12 December 2020

Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D

1 reference

12 December 2020

Dietary xylitol retards the ovariectomy-induced increase of bone turnover in rats

1 reference

12 December 2020

The food-induced stimulation of bone resorption in the rat, assessed by the urinary [3H]-tetracycline excretion, is mediated by parathyroid hormone

1 reference

12 December 2020

Concentration and persistence of tetracycline and chlortetracycline in bone

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12 December 2020

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

1 reference

12 December 2020

Antibiotic distribution in normal and osteomyelitic bone

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12 December 2020

10.2165/00003088-200342100-00001

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12885262%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 November 2019

1009793092

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Fatcat ID

release_l2fpqydsengdpnze3mitbqxdbe

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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