(Q35198415)

7 August 2017

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title

The ins and outs of STAT1 nuclear transport (English)

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7 August 2017

Kevin M McBride

1

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7 August 2017

Nancy C Reich

series ordinal

2

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7 August 2017

publication date

12 August 2003

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Science's STKE : signal transduction knowledge environment

7 August 2017

published in

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7 August 2017

volume

2003

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7 August 2017

issue

195

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7 August 2017

page(s)

RE13

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The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

The Janus protein tyrosine kinases in hematopoietic cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

The Jak/STAT pathway in model organisms: emerging roles in cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Signaling through the JAK/STAT pathway, recent advances and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cloning and developmental expression of STAT5 in Xenopus laevis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cloning and developmental expression of Xenopus Stat1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cooperation of the transcriptional coactivators CBP and p300 with Stat6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Role of metazoan mediator proteins in interferon-responsive transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Essential role of Stat6 in IL-4 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Functional roles of STAT family proteins: lessons from knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

STAT signaling in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Pharmaceutical intervention in the JAK/STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

21 January 2018

Proteomics for the pore

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

The nuclear pore complex as a transport machine.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nucleocytoplasmic transport: the soluble phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Transport between the cell nucleus and the cytoplasm

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Karyopherins and nuclear import

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Transport into and out of the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nucleocytoplasmic transport: Ran, beta and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nuclear targeting sequences--a consensus?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Determination of the functional domain organization of the importin alpha nuclear import factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Structure of importin-beta bound to the IBB domain of importin-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

In or out? Regulating nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Regulation of nuclear localization: a key to a door

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cytokine signaling: STATS in plasma membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

STAT1 from the cell membrane to the DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Design of conditionally active STATs: insights into STAT activation and gene regulatory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Signalling shortcuts: cell-surface receptors in the nucleus?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Hypothesis: ligand/receptor-assisted nuclear translocation of STATs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nuclear translocation of IFN-gamma is an intrinsic requirement for its biologic activity and can be driven by a heterologous nuclear localization sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Dynamic redistribution of STAT1 protein in IFN signaling visualized by GFP fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Regulation of STAT1 nuclear export by Jak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Protein tyrosine phosphatases in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Combinatorial control of the specificity of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Identification of a nuclear Stat1 protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Finding nuclear localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Synergistic activity of STAT3 and c-Jun at a specific array of DNA elements in the alpha 2-macroglobulin promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Cytoplasmic transport of Stat3 by receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Functional interactions between Stat5 and the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

The Dictyostelium prestalk cell inducer DIF regulates nuclear accumulation of a STAT protein by controlling its rate of export from the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

Immune response in Stat2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

21 January 2018

The nuclear pore complex

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.195.RE13

10.1126/STKE.2003.195.RE13

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference