(Q35205864)

7 August 2017

title

Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo (English)

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acetaminophen mercapturate

7 August 2017

main subject

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ChEBI release 2020-05-28

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1 reference

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B H Lauterburg

1

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7 August 2017

G B Corcoran

series ordinal

2

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7 August 2017

J R Mitchell

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

1 April 1983

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Journal of Clinical Investigation

7 August 2017

published in

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7 August 2017

volume

71

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7 August 2017

issue

4

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7 August 2017

page(s)

980-991

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7 August 2017

cites work

Tissue sulfhydryl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Toxic doses of acetaminophen suppress hepatic glutathione synthesis in rats.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Clinical pharmacokinetics of paracetamol

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Regulation of Hepatic Glutathione Turnover in Rats In Vivo and Evidence for Kinetic Homogeneity of the Hepatic Glutathione Pool

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Studies on the regulation of glutathione level in rat liver

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Reduction of disulphide bonds in proteins mixed disulphides catalysed by a thioltransferase in rat liver cytosol

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Pathophysiology of acetaminophen overdosage toxicity: implications for management

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Reversal of experimental paracetamol toxicosis with N-acetylcysteine

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=436956

N-acetylcysteine-induced inhibition of gastric emptying: A mechanism affording protection to mice from the hepatotoxicity of concomitantly administered acetaminophen

13 July 2018

1 reference

12 December 2020

Dose- and time-dependent elimination of acetaminophen in rats: pharmacokinetic implications of cosubstrate depletion

1 reference

12 December 2020

Effect of acetaminophen (paracetamol) and its antagonists on glutathione (GSH) content in rat liver

1 reference

12 December 2020

Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography

1 reference

12 December 2020

Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1 reference

12 December 2020

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

1 reference

12 December 2020

The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis

1 reference

12 December 2020

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

1 reference

12 December 2020

Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.

1 reference

12 December 2020

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1 reference

12 December 2020

Effect of N-acetylcysteine on the pharmacokinetics of acetaminophen in rats

1 reference

12 December 2020

Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicity. 1. Inhibition of the covalent binding of acetaminophen metabolites to hepatic microsomes in vitro

1 reference

12 December 2020

Effects of N-acetylcysteine on metabolism, covalent binding, and toxicity of acetaminophen in isolated mouse hepatocytes

1 reference

12 December 2020

Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation

1 reference

12 December 2020

Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine

1 reference

12 December 2020

Hydroperoxide-Metabolizing Systems in Rat Liver

1 reference

12 December 2020

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

1 reference

12 December 2020

Metabolic studies with acetylcysteine

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12 December 2020

Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats

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12 December 2020

Treating acute acetaminophen poisoning with acetylcysteine

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI110853

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7 August 2017

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7 August 2017

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