(Q35216450)

7 August 2017

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title

What pharmacologists can learn from recent advances in estrogen signalling (English)

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7 August 2017

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Jan-Ake Gustafsson

1

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7 August 2017

1 September 2003

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Trends in Pharmacological Sciences

7 August 2017

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7 August 2017

24

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7 August 2017

479-485

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7 August 2017

9

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Update on the current use of hormonals as therapy in advanced breast cancer

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Side Effects of Adjuvant Endocrine Treatment in Premenopausal Breast Cancer Patients: A Prospective Randomized Study

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Tamoxifen effects on subjective and psychosexual well-being, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Cloning of a novel receptor expressed in rat prostate and ovary

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Generation and reproductive phenotypes of mice lacking estrogen receptor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Mechanisms of estrogen action

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Immunolocalization of Estrogen Receptor β in the Mouse Brain: Comparison with Estrogen Receptor α

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor beta is expressed in human colorectal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The beta form of the estrogen receptor is predominantly expressed in the papillary cystic neoplasm of the pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Expression of estrogen receptors alpha and beta in human lung tissue and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptors alpha and beta in the inner ear of the 'Turner mouse' and an estrogen receptor beta knockout mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Expression of estrogen receptors alpha and beta by sympathetic ganglion neurons projecting to the proximal urethra of female rats

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor pathways to AP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

4-hydroxytamoxifen trans-represses nuclear factor-kappa B activity in human osteoblastic U2-OS cells through estrogen receptor (ER)alpha, and not through ER beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor beta is involved in the anorectic action of estrogen

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Placental expression of estrogen receptor beta and its hormone binding variant--comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Increased expression of estrogen receptor beta in human uterine smooth muscle at term

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Role of estrogen receptor-beta in regulation of vasopressin and oxytocin release in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Neonatal imprinting and regulation of estrogen receptor alpha and beta mRNA expression by estrogen in the pituitary and hypothalamus of the male rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estradiol masculinizes the posteromedial cortical nucleus of the amygdala in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen actions in the ovary revisited.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Identification of a splice variant of the rat estrogen receptor β gene

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

A role for estrogen receptor beta in the regulation of growth of the ventral prostate

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Role of stroma in carcinogenesis of the prostate.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptors and proliferation markers in primary and recurrent breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptors alpha and beta in the rodent mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Differential SERM effects on corepressor binding dictate ERalpha activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estrogen receptor beta in breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Agonistic effect of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: functional difference between estrogen receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Clinical impact of assay of estrogen receptor beta cx in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Epidemiology of phytoestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Evaluation of the estrogenic effects of legume extracts containing phytoestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Reversal of bone loss in mice by nongenotropic signaling of sex steroids

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

The steroid and thyroid hormone receptor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900229-3

7 January 2021

10.1016/S0165-6147(03)00229-3

Identifiers

DOI

1 reference

7 August 2017

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PubMed ID

12967773