(Q35230204)

7 August 2017

title

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation (English)

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7 August 2017

Ludmila Jirmanova

1

1 reference

7 August 2017

Maria Letizia Giardino Torchia

2

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7 August 2017

Nandakumara D Sarma

3

1 reference

7 August 2017

Paul R Mittelstadt

4

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7 August 2017

Jonathan D Ashwell

5

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7 August 2017

language of work or name

English

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publication date

28 June 2011

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7 August 2017

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7 August 2017

volume

118

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7 August 2017

issue

12

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7 August 2017

page(s)

3280-3289

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Kinase inhibitors: a new approach to rheumatoid arthritis treatment

7 August 2017

cites work

1 reference

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27 July 2018

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27 July 2018

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T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity

27 July 2018

1 reference

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Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production

27 July 2018

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27 July 2018

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The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay

27 July 2018

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Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 Mitogen-activated protein kinases for treatment of cancer. A systematic review of the literature

27 July 2018

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27 July 2018

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Impaired immune response to Candida albicans in aged mice

27 July 2018

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27 July 2018

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27 July 2018

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IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

27 July 2018

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27 July 2018

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27 July 2018

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Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice

27 July 2018

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Active mutants of the human p38alpha mitogen-activated protein kinase

27 July 2018

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Glucocorticoids and the Th1/Th2 balance

27 July 2018

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The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation

27 July 2018

1 reference

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Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

27 July 2018

1 reference

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The primary structure of p38 gamma: a new member of p38 group of MAP kinases

27 July 2018

1 reference

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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

27 July 2018

1 reference

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Differential pharmacological behaviour of p38 inhibitors in regulating the LPS-induced TNF-α production in human and rat whole blood in vitro

27 July 2018

1 reference

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Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

26 September 2018

1 reference

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A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients

26 September 2018

1 reference

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

26 September 2018

1 reference

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Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy

26 September 2018

1 reference

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Epigallocatechin-3-gallate suppresses TNF-alpha -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

A statistically defined endpoint titer determination method for immunoassays.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179397

Peripheral neuropathy in chronic obstructive pulmonary disease

26 September 2018

1 reference

12 December 2020

Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice

1 reference

12 December 2020

Genomic instability in Gadd45a-deficient mice

1 reference

12 December 2020

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

1 reference

12 December 2020

Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53

1 reference

12 December 2020

Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant

1 reference

12 December 2020

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

1 reference

12 December 2020

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages

1 reference

12 December 2020

10.1182/BLOOD-2011-01-333039

Identifiers

DOI

1 reference

7 August 2017

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7 August 2017

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