(Q35232774)

English

Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Alzheimer's disease

0 references

author name string

Christopher R Simmons

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Fanggeng Zou

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Steven G Younkin

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Steven Estus

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

publication date

25 August 2011

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Molecular Neurodegeneration

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

62

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Apolipoprotein E in Alzheimer's disease and other neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180274

27 July 2018

Global analysis of the impact of environmental perturbation on cis-regulation of gene expression

1 reference

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Report of the task force on designing clinical trials in early (predementia) AD.

1 reference

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Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals

1 reference

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Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

1 reference

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27 July 2018

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

1 reference

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27 July 2018

Expression and regulation of a low‐density lipoprotein receptor exon 12 splice variant

1 reference

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Biological, clinical and population relevance of 95 loci for blood lipids

1 reference

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27 July 2018

Cholesterol-related genes in Alzheimer's disease

1 reference

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27 July 2018

Replication of CLU, CR1, and PICALM associations with alzheimer disease.

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27 July 2018

Role of SFRS13A in low-density lipoprotein receptor splicing

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27 July 2018

Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK

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27 July 2018

Splicing factor and exon profiling across human tissues

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27 July 2018

Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study

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27 July 2018

Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions

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27 July 2018

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180274

27 July 2018

The role of apolipoprotein E in Alzheimer's disease

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27 July 2018

Common regulatory variation impacts gene expression in a cell type-dependent manner

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27 July 2018

Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.

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27 July 2018

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

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27 July 2018

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

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27 July 2018

Common variants at 30 loci contribute to polygenic dyslipidemia

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27 July 2018

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

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27 July 2018

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13

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27 July 2018

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180274

27 July 2018

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

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27 July 2018

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

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27 July 2018

Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease

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27 July 2018

PLINK: a tool set for whole-genome association and population-based linkage analyses

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Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis

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27 July 2018

Minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing

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27 July 2018

Role of Genes and Environments for Explaining Alzheimer Disease

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27 July 2018

Use of minigene systems to dissect alternative splicing elements

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Selection of reference genes for gene expression studies in human neutrophils by real-time PCR

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27 July 2018

Brain cholesterol: long secret life behind a barrier.

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27 July 2018

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

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27 July 2018

Statin inhibition of HMG-CoA reductase: a 3-dimensional view

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27 July 2018

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27 July 2018

Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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27 July 2018

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27 July 2018

Structural mechanism for statin inhibition of HMG-CoA reductase

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27 July 2018

Statins and the risk of dementia

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27 July 2018

Heritability for Alzheimer's disease: the study of dementia in Swedish twins

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27 July 2018

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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27 July 2018

Apolipoprotein E and Alzheimer disease

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27 July 2018

Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease

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21 January 2018

Association study of cholesterol-related genes in Alzheimer's disease.

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21 January 2018

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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LDL-cholesterol concentrations: a genome-wide association study

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Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.

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Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

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Genetic variants influencing circulating lipid levels and risk of coronary artery disease

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Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese

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21 January 2018

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment

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A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol.

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26 September 2018

Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.

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A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.

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26 September 2018

Pharmacogenetic study of statin therapy and cholesterol reduction

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Cholesterol's role in synapse formation

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Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

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Statin Use and the Risk of Incident Dementia

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21 January 2018

Identifiers

10.1186/1750-1326-6-62

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

ResearchGate publication ID

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