(Q35240492)

7 August 2017

title

RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells. (English)

1 reference

7 August 2017

1 reference

Maaike P A van Bragt

1

1 reference

7 August 2017

Xin Hu

series ordinal

2

1 reference

7 August 2017

Ying Xie

series ordinal

3

1 reference

7 August 2017

Zhe Li

series ordinal

4

1 reference

7 August 2017

language of work or name

English

0 references

publication date

21 November 2014

1 reference

7 August 2017

1 reference

7 August 2017

volume

3

1 reference

7 August 2017

page(s)

e03881

1 reference

Identification of multipotent mammary stem cells by protein C receptor expression.

7 August 2017

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Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer

27 July 2018

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27 July 2018

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Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

27 July 2018

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27 July 2018

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RUNX family: Regulation and diversification of roles through interacting proteins

27 July 2018

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Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland

27 July 2018

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Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

27 July 2018

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Runx1: no longer just for leukemia

27 July 2018

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27 July 2018

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Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland

27 July 2018

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27 July 2018

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Whole-genome analysis informs breast cancer response to aromatase inhibition

27 July 2018

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Slug and Sox9 cooperatively determine the mammary stem cell state

27 July 2018

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A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer

27 July 2018

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Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.

27 July 2018

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Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness

27 July 2018

1 reference

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Smooth muscle α actin is specifically required for the maintenance of lactation

27 July 2018

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Defining the cellular precursors to human breast cancer

27 July 2018

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RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

27 July 2018

1 reference

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Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin

27 July 2018

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Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

FOXA1 is a key determinant of estrogen receptor function and endocrine response

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged

27 July 2018

1 reference

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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5.

27 July 2018

1 reference

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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

27 July 2018

1 reference

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The Ets transcription factor Elf5 specifies mammary alveolar cell fate

27 July 2018

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Bifurcation dynamics in lineage-commitment in bipotent progenitor cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Generation of a functional mammary gland from a single stem cell

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Purification and unique properties of mammary epithelial stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Runx1 function in hematopoiesis is required in cells that express Tek

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

A molecular signature of metastasis in primary solid tumors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Core-binding factors in haematopoiesis and leukaemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Cre-mediated gene deletion in the mammary gland

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

In situ identification of bipotent stem cells in the mammary gland.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

New insights into the role of Runx1 in epithelial stem cell biology and pathology

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

The RUNX family in breast cancer: relationships with estrogen signaling

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Control of mammary stem cell function by steroid hormone signalling.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Rapid development of tamoxifen-stimulated mutant p53 breast tumors (T47D) in athymic mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381933

Erratum: Integrated genomic analyses of ovarian carcinoma

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.03881

Distinct stem cells contribute to mammary gland development and maintenance

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.03881

Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25415051

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25415051

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.03881

1 reference

7 August 2017

1 reference

7 August 2017

1 reference