(Q35257790)

7 August 2017

title

Treatment of congenital lactic acidosis with dichloroacetate (English)

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Congenital lactic acidosis

7 August 2017

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P W Stacpoole

1

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7 August 2017

C L Barnes

2

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7 August 2017

M D Hurbanis

3

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7 August 2017

S L Cannon

4

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7 August 2017

D S Kerr

5

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7 August 2017

language of work or name

English

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publication date

1 December 1997

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Archives of Disease in Childhood

7 August 2017

published in

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7 August 2017

volume

77

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7 August 2017

issue

6

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7 August 2017

page(s)

535-541

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Lactic acidosis and other mitochondrial disorders

7 August 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

The expanding clinical spectrum of mitochondrial diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Mitochondrial encephalomyopathy. A variant with heart failure and liver steatosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

A deficiency of both subunits of pyruvate dehydrogenase which is not expressed in fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Effect of sodium dichloroacetate on human pyruvate metabolism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

The pharmacology of dichloroacetate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Cytochrome c oxidase deficiency in infancy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Neonatal pyruvate dehydrogenase deficiency with lipoate responsive lactic acidaemia and hyperammonaemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Chronic toxicity of dichloroacetate: possible relation to thiamine deficiency in rats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Defects in the E2 lipoyl transacetylase and the X-lipoyl containing component of the pyruvate dehydrogenase complex in patients with lactic acidemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

12 July 2018

Biotinidase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

MELAS of infantile onset: mitochondrial angiopathy or cytopathy?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Lactic acidosis, neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Lactic acidosis due to pyruvate carboxylase deficiency.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Mitochondrial cytochrome deficiency presenting as a myopathy with hypotonia, external ophthalmoplegia, and lactic acidosis in an infant and as fatal hepatopathy in a second cousin.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyperammonemia: responses to dichloroacetate and benzoate.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1717417

Ketonic diet in the management of pyruvate dehydrogenase deficiency

26 September 2018

1 reference

12 December 2020

Dichloroacetate as treatment for congenital lactic acidosis

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12 December 2020

Brief treatment with dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis

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12 December 2020

Dichloroacetate in the treatment of congenital lactic acidosis

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12 December 2020

Treatment of lactic acidosis: effects of dichloroacetate on lactate and pyruvate levels in the cerebrospinal fluid

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12 December 2020

Renal effects of dichloroacetate in vivo

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12 December 2020

Fatal lactic acidosis due to deficiency of E1 component of the pyruvate dehydrogenase complex

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12 December 2020

Mitochondrial myopathy and cardiomyopathy in siblings

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12 December 2020

Feeding problems and lactic acidosis in a 10-week-old boy

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12 December 2020

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12 December 2020

Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency

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12 December 2020

Transient improvement of congenital lactic acidosis in a male infant with pyruvate decarboxylase deficiency treated with dichloroacetate

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12 December 2020

Familial recurrence of atypical symptoms in an extended pedigree with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)

1 reference

12 December 2020

Congenital lacticacidemia caused by lipoamide dehydrogenase deficiency with favorable outcome

1 reference

12 December 2020

The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein

1 reference

12 December 2020

Identifiers

DOI

10.1136/ADC.77.6.535

1 reference

7 August 2017

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7 August 2017

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