(Q35298758)

7 August 2017

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title

Fatty acid metabolism and insulin secretion in pancreatic beta cells (English)

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7 August 2017

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Yaney GC

1

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7 August 2017

Corkey BE

series ordinal

2

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7 August 2017

language of work or name

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12 September 2003

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7 August 2017

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7 August 2017

volume

46

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7 August 2017

issue

10

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7 August 2017

page(s)

1297-1312

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https://scigraph.springernature.com/pub.10.1007/s00125-003-1207-4

7 August 2017

exact match

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cites work

The antidiabetic beta 3-adrenoceptor agonist BRL 26830A works by release of endogenous insulin

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12 December 2020

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

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12 December 2020

Chromaffin cell cortical actin network dynamics control the size of the release-ready vesicle pool and the initial rate of exocytosis

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12 December 2020

Phosphorylation of 25-kDa synaptosome-associated protein. Possible involvement in protein kinase C-mediated regulation of neurotransmitter release

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12 December 2020

Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content

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12 December 2020

Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion

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12 December 2020

Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion

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12 December 2020

Identification and subcellular characterization of protein kinase-C isoforms in insulinoma beta-cells and whole islets

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12 December 2020

Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

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12 December 2020

Acyl CoA regulation of metabolism and signal transduction

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12 December 2020

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats

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12 December 2020

The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient

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12 December 2020

Targeting of SNAP-25 to membranes is mediated by its association with the target SNARE syntaxin

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12 December 2020

Regulation of protein kinase C.

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12 December 2020

Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels.

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12 December 2020

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

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12 December 2020

New insights into the mitochondrial carnitine palmitoyltransferase enzyme system

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12 December 2020

Glucose-induced translocation of protein kinase C in rat pancreatic islets

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12 December 2020

Obesity and insulin resistance

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12 December 2020

Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell

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12 December 2020

Ca2+/calmodulin and cyclic 3,5' adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic beta-cell

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12 December 2020

Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity

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12 December 2020

Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract

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12 December 2020

Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release.

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12 December 2020

Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells

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12 December 2020

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

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12 December 2020

Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans

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12 December 2020

Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1).

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12 December 2020

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

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12 December 2020

Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells

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12 December 2020

Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis

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12 December 2020

Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae

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12 December 2020

Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells

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12 December 2020

Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic beta-cell line

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12 December 2020

Chronic exposure to TPA depletes PKC alpha and augments Ca-dependent insulin secretion from cultured rat islets.

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12 December 2020

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion

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12 December 2020

Two different spatiotemporal patterns for Ca2+ oscillations in pancreatic acinar cells: evidence of a role for protein kinase C in Ins(1,4,5)P3-mediated Ca2+ signalling

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12 December 2020

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

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12 December 2020

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

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12 December 2020

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion

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12 December 2020

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent

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12 December 2020

A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells

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12 December 2020

Molecular machinery mediating vesicle budding, docking and fusion

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12 December 2020

Secretagogue-induced [Ca2+]i changes in single rat pancreatic islets and correlation with simultaneously measured insulin release

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12 December 2020

Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25

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12 December 2020

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells

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12 December 2020

ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis

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12 December 2020

Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration

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12 December 2020

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets

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12 December 2020

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

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12 December 2020

Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules

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12 December 2020

The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositoltrisphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancreatic islets

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12 December 2020

Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel.

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12 December 2020

Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.

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12 December 2020

Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid.

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12 December 2020

Contribution of L- and non-L-type calcium channels to voltage-gated calcium current and glucose-dependent insulin secretion in HIT-T15 cells

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12 December 2020

Hexamminecobalt(III) chloride inhibits glucose-induced insulin secretion at the exocytotic process

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12 December 2020

Regulation of the readily releasable vesicle pool by protein kinase C.

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12 December 2020

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

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12 December 2020

Effects of ketone bodies on insulin release and islet-cell metabolism in the rat

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12 December 2020

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

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12 December 2020

SNAP-25 palmitoylation and plasma membrane targeting require a functional secretory pathway

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12 December 2020

Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats

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12 December 2020

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain f

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12 December 2020

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

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12 December 2020

Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion

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12 December 2020

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

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12 December 2020

Inhibition of the hormone-sensitive lipase in adipose tissue by long-chain fatty acyl coenzyme A

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12 December 2020

Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids

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12 December 2020

Regulation of insulin secretion by phospholipase C.

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12 December 2020

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion

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12 December 2020

Coupling factors in nutrient-induced insulin release

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12 December 2020

Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells

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12 December 2020

Low density lipoprotein binding and uptake by human and rat islet beta cells

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12 December 2020

Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells

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12 December 2020

Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT).

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12 December 2020

Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.

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12 December 2020

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets

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12 December 2020

The expression of hormone-sensitive lipase in clonal beta-cells and rat islets is induced by long-term exposure to high glucose

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12 December 2020

β3-Adrenergic Receptors on White and Brown Adipocytes Mediate β3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake

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12 December 2020

Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion

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12 December 2020

Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose

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12 December 2020

Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain.

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12 December 2020

Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: evidence for insulin resistance.

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12 December 2020

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation

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12 December 2020

Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

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12 December 2020

Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6.

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12 December 2020

Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C

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12 December 2020

Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

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12 December 2020

Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion

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12 December 2020

The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release

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12 December 2020

How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

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12 December 2020

Banting lecture 1990. Beta-cells in type II diabetes mellitus

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12 December 2020

Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion

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12 December 2020

Global and societal implications of the diabetes epidemic

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12 December 2020

Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin

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12 December 2020

Calmodulin and protein kinase C increase Ca(2+)-stimulated secretion by modulating membrane-attached exocytic machinery

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12 December 2020

Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction

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12 December 2020

Inhibition of cardiac L-type calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain

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12 December 2020

The Cell Physiology of Biphasic Insulin Secretion.

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12 December 2020

Stimulation of insulin secretion by infusion of free fatty acids

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12 December 2020

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

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12 December 2020

Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets

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12 December 2020

Fatty acylation promotes fusion of transport vesicles with Golgi cisternae

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12 December 2020

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

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12 December 2020

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion

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12 December 2020

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

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12 December 2020

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans

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12 December 2020

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

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12 December 2020

Signal transduction mechanisms in nutrient-induced insulin secretion

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12 December 2020

Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets

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12 December 2020

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

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12 December 2020

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

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12 December 2020

Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior

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12 December 2020

Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT).

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12 December 2020

Targeted disruption of the beta 3-adrenergic receptor gene.

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12 December 2020

Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin

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12 December 2020

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA

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12 December 2020

Plasma Triglyceride and Fatty Acid Metabolism in Diabetes mellitus

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12 December 2020

Evidence for a Unique Long Chain Acyl-CoA Ester Binding Site on the ATP-regulated Potassium Channel in Mouse Pancreatic Beta Cells

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12 December 2020

Are metabolic oscillations responsible for normal oscillatory insulin secretion?

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12 December 2020

Palmitate dependence of insulin secretion, "de novo" phospholipid synthesis and 45Ca2+-turnover in glucose stimulated rat islets

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12 December 2020

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation

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12 December 2020

The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets

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12 December 2020

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle

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12 December 2020

What if Minkowski had been ageusic? An alternative angle on diabetes

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12 December 2020

Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells

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12 December 2020

Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets

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12 December 2020

Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets

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12 December 2020

Studies on the interaction of palmitoyl coenzyme A with the adenine nucleotide translocase

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12 December 2020

Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: contrasting patterns of glyceraldehyde phosphate and succinate

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12 December 2020

Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells

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12 December 2020

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.

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12 December 2020

ATP-sensitive K channel modulation by products of PLA2 action in the insulin-secreting HIT cell line

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12 December 2020

Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells

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12 December 2020

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

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12 December 2020

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin

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12 December 2020

Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic beta-cell

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12 December 2020

Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

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12 December 2020

Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting

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12 December 2020

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

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12 December 2020

Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).

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12 December 2020

Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function

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12 December 2020

Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells

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12 December 2020

Protein kinase C acylation by palmitoyl coenzyme A facilitates its translocation to membranes.

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12 December 2020

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes

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12 December 2020

Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets

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12 December 2020

A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice.

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12 December 2020

The fuel concept for insulin release: regulation of glucose phosphorylation in pancreatic islets

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12 December 2020

Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets

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12 December 2020

Pulsatile insulin secretion: detection, regulation, and role in diabetes

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12 December 2020

Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell

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12 December 2020

Temporal and quantitative correlations between insulin secretion and stably elevated or oscillatory cytoplasmic Ca2+ in mouse pancreatic beta-cells.

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12 December 2020

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells

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12 December 2020

Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2+

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12 December 2020

A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C

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12 December 2020

The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies

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12 December 2020

ATP-sensitive K+ channel-independent glucose action in rat pancreatic beta-cell.

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12 December 2020

Mechanism of glucose-induced insulin secretion

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12 December 2020

Beneficial effect of diazoxide in obese hyperinsulinemic adults

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12 December 2020

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

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12 December 2020

Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

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12 December 2020

Fatty acids and beta-cell function

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12 December 2020

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

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12 December 2020

Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules

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12 December 2020

K(ATP) channels: linker between phospholipid metabolism and excitability

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12 December 2020

The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery

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12 December 2020

Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion

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12 December 2020

Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP.

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12 December 2020

Analysis of acyl-coenzyme A esters in biological samples.

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12 December 2020

High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study

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12 December 2020

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

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12 December 2020

Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction

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12 December 2020

Protein kinase C and calcium regulation of adenylyl cyclase in isolated rat pancreatic islets

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12 December 2020

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

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12 December 2020

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

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12 December 2020

Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms

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12 December 2020

Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells

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12 December 2020

Effects of Carbohydrates on the Oxygen Consumption of Isolated Pancreatic Islets of Mice

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12 December 2020

Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets.

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12 December 2020

Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons

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12 December 2020

Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells

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12 December 2020

10.1007/S00125-003-1207-4

Identifiers

DOI

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7 August 2017

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