(Q35312313)

7 August 2017

title

Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation (English)

1 reference

7 August 2017

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Joong-Youn Shim

1

1 reference

7 August 2017

Alexander C Bertalovitz

series ordinal

2

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7 August 2017

Debra A Kendall

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

27 July 2011

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Journal of Biological Chemistry

7 August 2017

published in

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7 August 2017

volume

286

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7 August 2017

issue

38

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7 August 2017

page(s)

33422-33435

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

7 August 2017

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12 July 2018

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12 July 2018

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

12 July 2018

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Crystal structure of opsin in its G-protein-interacting conformation

12 July 2018

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Structure of a beta1-adrenergic G-protein-coupled receptor

12 July 2018

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

12 July 2018

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12 July 2018

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High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Balancing solvation and intramolecular interactions: toward a consistent generalized Born force field

12 July 2018

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F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist

12 July 2018

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Scalable molecular dynamics with NAMD

12 July 2018

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Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation

12 July 2018

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Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR.

12 July 2018

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Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial

12 July 2018

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An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

12 July 2018

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12 July 2018

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12 July 2018

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Established and potential therapeutic applications of cannabinoids in oncology

12 July 2018

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Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin

12 July 2018

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Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

12 July 2018

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

12 July 2018

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12 July 2018

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Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent

12 July 2018

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12 July 2018

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The maximal affinity of ligands

12 July 2018

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Canonical dynamics: Equilibrium phase-space distributions

12 July 2018

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Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.

12 July 2018

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Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

12 July 2018

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12 July 2018

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12 July 2018

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A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2.

12 July 2018

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12 July 2018

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The pore dimensions of gramicidin A.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints

26 September 2018

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Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

26 September 2018

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26 September 2018

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26 September 2018

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(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor

26 September 2018

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Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding

26 September 2018

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The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

26 September 2018

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Overcoming free energy barriers using unconstrained molecular dynamics simulations

26 September 2018

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Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A

26 September 2018

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A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition

26 September 2018

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Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors

26 September 2018

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26 September 2018

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Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.

26 September 2018

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26 September 2018

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

26 September 2018

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26 September 2018

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Determining atom-centered monopoles from molecular electrostatic potentials. The need for high sampling density in formamide conformational analysis

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Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

21 January 2018

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12 December 2020

Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs

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12 December 2020

Steric trigger as a mechanism for CB1 cannabinoid receptor activation

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12 December 2020

Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871)

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12 December 2020

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

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12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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12 December 2020

The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)

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12 December 2020

Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.261651

1 reference

7 August 2017

1 reference

7 August 2017

1 reference