(Q35372195)

8 August 2017

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title

Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors (English)

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8 August 2017

H. K. Kroemer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1395362

22 September 2022

U. Klotz

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1395362

22 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1395362

22 September 2022

publication date

1 October 1992

1 reference

Clinical Pharmacokinetics

8 August 2017

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8 August 2017

23

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8 August 2017

292-310

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8 August 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-199223040-00005

8 August 2017

0 references

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12 December 2020

Effect of age and gender on disposition of temazepam

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12 December 2020

New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease"

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12 December 2020

Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking

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12 December 2020

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine

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12 December 2020

Chemical synthesis and growth-promoting activity of all-trans-retinyl beta-D-glucuronide

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12 December 2020

Comparative effects of rifampin and/or probenecid on the pharmacokinetics of temazepam and nitrazepam

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12 December 2020

Effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) and its metabolites.

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12 December 2020

Sources of interindividual variations in acetaminophen and antipyrine metabolism

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12 December 2020

The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions

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12 December 2020

Long lasting respiratory depression induced by morphine-6-glucuronide?

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12 December 2020

Glucuronide conjugation in the lung

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12 December 2020

Drug metabolism in thyroid disease

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12 December 2020

Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients

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12 December 2020

Ethynylestradiol-17 beta D-ring glucuronide conjugates are potent cholestatic agents in the rat

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12 December 2020

Human liver morphine UDP-glucuronyl transferase enantioselectivity and inhibition by opioid congeners and oxazepam

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12 December 2020

Chlordiazepoxide and oxazepam disposition in cirrhosis

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12 December 2020

Clinical pharmacology of NSAIDs

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12 December 2020

Electrophilic reactions of acyl-linked glucuronides. Formation of clofibrate mercapturate in humans

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12 December 2020

Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity

1 reference

12 December 2020

Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis

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12 December 2020

Effects and metabolic pathway of 4-dimethylaminophenol during kidney perfusion

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12 December 2020

Interaction of metoprolol with lorazepam and bromazepam

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12 December 2020

Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine

1 reference

12 December 2020

Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs

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12 December 2020

Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers

1 reference

12 December 2020

Reduction of paracetamol and aspirin metabolism during viral hepatitis

1 reference

12 December 2020

UDP-glucuronosyltransferases: a family of detoxifying enzymes

1 reference

12 December 2020

Absence of morphine glucuronidation in the human lung

1 reference

12 December 2020

Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats.

1 reference

12 December 2020

Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine.

1 reference

12 December 2020

Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism

1 reference

12 December 2020

Comparison of paracetamol metabolism in young adult and elderly males

1 reference

12 December 2020

Protein binding of oxazepam and its glucuronide conjugates to human albumin.

1 reference

12 December 2020

Temazepam clearance unaltered in cirrhosis

1 reference

12 December 2020

Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism

1 reference

12 December 2020

Hepatic drug conjugation/deconjugation systems in hepatosplenic schistosomiasis

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12 December 2020

Analgesic Effect of Morphine Glucuronides

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12 December 2020

Steroid D-ring glucuronides: characterization of a new class of cholestatic agents in the rat

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12 December 2020

Kinetics of diazepam, midazolam, and lorazepam in cigarette smokers.

1 reference

12 December 2020

Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen

1 reference

12 December 2020

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

1 reference

12 December 2020

Morphine-6-glucuronide has high affinity for the opioid receptor

1 reference

12 December 2020

Reactions of oxaprozin-1-O-acyl glucuronide in solutions of human plasma and albumin

1 reference

12 December 2020

Impaired biliary elimination of beta-glucuronidase-resistant "glucuronides" of valproic acid after intravenous administration in the rat. Evidence for oxidative metabolism of the resistant isomers

1 reference

12 December 2020

Clofibrate disposition in renal failure and acute and chronic liver disease

1 reference

12 December 2020

Intrathecal high dose morphine produces hyperalgesia in the rat

1 reference

12 December 2020

Acylation of albumin by 1-O-acyl glucuronides

1 reference

12 December 2020

Hepatic extraction of morphine is impaired in cirrhosis

1 reference

12 December 2020

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1 reference

12 December 2020

Oxazepam disposition in uremic patients

1 reference

12 December 2020

Hepatotoxic effects of estradiol-17 beta-D-glucuronide in the rat and monkey

1 reference

12 December 2020

Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex

1 reference

12 December 2020

Clinical pharmacokinetic considerations in the elderly. An update

1 reference

12 December 2020

Foreign compound metabolism by isolated skin cells from the hairless mouse

1 reference

12 December 2020

Rapid conjugation in an extremely rapid hydroxylator of debrisoquine: a case report supporting a coregulation of certain phase I and II metabolic reactions

1 reference

12 December 2020

Inter-subject and ethnic differences in paracetamol metabolism

1 reference

12 December 2020

Effects of microsomal enzyme induction on paracetamol metabolism in man

1 reference

12 December 2020

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

1 reference

12 December 2020

Analgesic activity of morphine-6-glucuronide

1 reference

12 December 2020

Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study

1 reference

12 December 2020

The effect of propranolol on paracetamol metabolism in man

1 reference

12 December 2020

Differential Effects of Oral Contraceptive Steroids on the Metabolism of Benzodiazepines

1 reference

12 December 2020

Morphine-6-glucuronide might mediate the prolonged opioid effect of morphine in acute renal failure

1 reference

12 December 2020

Deconjugation of glucuronides catalysed by UDPglucuronyltransferase

1 reference

12 December 2020

Effects of aging and liver disease on disposition of lorazepam

1 reference

12 December 2020

Diisopropylfluorophosphate increases clofibric acid clearance: supporting evidence for a futile cycle.

1 reference

12 December 2020

Kinetics and biotransformation of lormetazepam. II. Radioimmunologic determinations in plasma and urine of young and elderly subjects: first-pass effect

1 reference

12 December 2020

A study of conjugation and drug elimination in the human neonate

1 reference

12 December 2020

Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes

1 reference

12 December 2020

Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.

1 reference

12 December 2020

Disposition of oxazepam in relation to age, sex, and cigarette smoking

1 reference

12 December 2020

Metabolism of hormones, drugs and other substances by the gut

1 reference

12 December 2020

Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome

1 reference

12 December 2020

Drug metabolism in liver disease

1 reference

12 December 2020

Glucuronidation of morphine in human kidney microsomes

1 reference

12 December 2020

Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity

1 reference

12 December 2020

Oxazepam kinetics: effects of age and sex.

1 reference

12 December 2020

The role of therapeutic drug monitoring in children

1 reference

12 December 2020

Is glucuronidation truly preserved in patients with liver disease?

1 reference

12 December 2020

Acetaminophen absorption and metabolism in celiac disease and Crohn's disease

1 reference

12 December 2020

Morphine intoxication in renal failure: the role of morphine-6-glucuronide

1 reference

12 December 2020

Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA

1 reference

12 December 2020

Hepatic drug metabolism and aging

1 reference

12 December 2020

Paracetamol metabolism in chronic liver disease

1 reference

12 December 2020

Drug disposition in obese humans. An update

1 reference

12 December 2020

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

1 reference

12 December 2020

Rearrangement of valproate glucuronide in a patient with drug-associated hepatobiliary and renal dysfunction

1 reference

12 December 2020

The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

1 reference

12 December 2020

Stereoselective disposition and glucuronidation of propranolol in humans

1 reference

12 December 2020

Morphine-3-glucuronide--a potent antagonist of morphine analgesia

1 reference

12 December 2020

Biotransformation and excretion of lorazepam in patients with chronic renal failure

1 reference

12 December 2020

1 reference

12 December 2020

Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation

1 reference

12 December 2020

Human brain sulphotransferase and glucuronyltransferase.

1 reference

12 December 2020

Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomes

1 reference

12 December 2020

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity.

1 reference

12 December 2020

Abnormal glucuronidation of zomepirac in patients with cirrhosis of the liver

1 reference

12 December 2020

Tumor-targeted cell killing with 8-hydroxyquinolyl-glucuronide

1 reference

12 December 2020

Tricyclic antidepressant and metabolite levels in chronic renal failure

1 reference

12 December 2020

Presystemic and systemic glucuronidation of propranolol

1 reference

12 December 2020

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle

1 reference

12 December 2020

Explanation for potency of repeated oral doses of morphine?

1 reference

12 December 2020

Oral morphine in cancer pain: influences on morphine and metabolite concentration

1 reference

12 December 2020

Morphine metabolism in cancer patients on increasing oral doses--no evidence for autoinduction or dose-dependence

1 reference

12 December 2020

Metabolism of low-dose paracetamol in patients with chronic neurological disease

1 reference

12 December 2020

Clinical pharmacokinetics and endocrine disorders. Therapeutic implications

1 reference

12 December 2020

Glucuronidation of oxazepam is not spared in patients with hepatic encephalopathy

1 reference

12 December 2020

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

1 reference

12 December 2020

Race and therapeutic drug response

1 reference

12 December 2020

Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal

1 reference

12 December 2020

Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin

1 reference

12 December 2020

In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation

1 reference

12 December 2020

Effect of renal dysfunction on the individual components of the acyl-glucuronide futile cycle

1 reference

12 December 2020

Oxazepam pharmacokinetics in thyroid disease

1 reference

12 December 2020

Odorant signal termination by olfactory UDP glucuronosyl transferase

1 reference

12 December 2020

Transplacental transfer and biotransformation studies of valproic acid and its glucuronide(s) in the perfused human placenta

1 reference

12 December 2020

The formation of beta-glucuronidase resistant glucuronides by the intramolecular rearrangement of glucuronic acid conjugates at mild alkaline pH.

1 reference

12 December 2020

Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies

1 reference

12 December 2020

Induction of differentiation of human promyelocytic leukemia cell line HL-60 by retinoyl glucuronide, a biologically active metabolite of vitamin A

1 reference

12 December 2020

pH-dependent rearrangement of the biosynthetic ester glucuronide of valproic acid to beta-glucuronidase-resistant forms

1 reference

12 December 2020

Metabolic formation of N- and O-glucuronides of 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid. Rearrangement of the 1-o-acyl glucuronide

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interaction study of diazepam and metoprolol.

1 reference

12 December 2020

Normal metabolism of morphine in cirrhosis

1 reference

12 December 2020

Morphine-6-glucuronide, a potent mu agonist.

1 reference

12 December 2020

Aging and determinants of hepatic drug clearance

1 reference

12 December 2020

Positive inotropic effects of digitoxin- and digoxin-glucuronide in human isolated ventricular heart muscle preparations

1 reference

12 December 2020

Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity

1 reference

12 December 2020

Clinical pharmacokinetics of contraceptive steroids. An update

1 reference

12 December 2020

Increased metabolic clearance of acetaminophen with oral contraceptive use

1 reference

12 December 2020

Glucuronidation and disposition of drug glucuronides in patients with renal failure. A review

1 reference

12 December 2020

Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture

1 reference

12 December 2020

The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man.

1 reference

12 December 2020

Stereoselective glucuronidation as a probe of induced forms of UDP-glucuronyltransferase in rabbits

1 reference

12 December 2020

Covalent binding of diflunisal and probenecid to plasma protein in humans: persistence of the adducts in the circulation

1 reference

12 December 2020

Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol

1 reference

12 December 2020

Lorazepam kinetics in the elderly

1 reference

12 December 2020

Acetaminophen in chronic liver disease

1 reference

12 December 2020

Paracetamol pharmacokinetics in thyroid disease

1 reference

12 December 2020

Effects of uremia and hemodialysis on lormetazepam disposition

1 reference

12 December 2020

UDP-glucuronosyltransferases

1 reference

12 December 2020

Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates

1 reference

12 December 2020

Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3′-azido-3′-deoxythymidine: Characterization of the enzyme in human and rat liver microsomes

1 reference

12 December 2020

Morphine-6-glucuronide, an important metabolite

1 reference

12 December 2020

Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates.

1 reference

12 December 2020

Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways

1 reference

12 December 2020

Interactions between oxaprozin glucuronide and human serum albumin

1 reference

12 December 2020

Kinetic and inhibitor studies of 4-methylumbelliferone and 1-naphthol glucuronidation in human liver microsomes

1 reference

12 December 2020

Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers

1 reference

12 December 2020

Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.

1 reference

12 December 2020

Apparent intramolecular acyl migration of zomepirac glucuronide

1 reference

12 December 2020

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells

1 reference

12 December 2020

Clinical pharmacokinetics of the salicylates

1 reference

12 December 2020

Tocainide kinetics and metabolism: effects of phenobarbital and substrates of glucuronyl transferase

1 reference

12 December 2020

Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides

1 reference

12 December 2020

Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine

1 reference

12 December 2020

Structure-activity relationship of the cholestatic activity of dihydrotestosterone glucuronide, allo bile acids and lithocholate

1 reference

12 December 2020

Salicyl phenolic glucuronide pharmacokinetics in patients with rheumatoid arthritis

1 reference

12 December 2020

A renal mechanism for the clofibric acid-probenecid interaction

1 reference

12 December 2020

The location of drug binding sites in human serum albumin

1 reference

12 December 2020

Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?

1 reference

12 December 2020

Irreversible binding of zomepirac to plasma protein in vitro and in vivo

1 reference

12 December 2020

Roles of UDP-glucuronosyltransferases in chemical carcinogenesis

1 reference

12 December 2020

Effect of oral contraceptive steroids on the pharmacokinetics of phenprocoumon

1 reference

12 December 2020

Effect of pentobarbital on the formation of diastereomeric oxazepam glucuronides in man: analysis by high performance liquid chromatography

1 reference

12 December 2020

Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.

1 reference

12 December 2020

Plasma levels of morphine and morphine glucuronides in the treatment of cancer pain: relationship to renal function and route of administration

1 reference

12 December 2020

Normal disposition of oxazepam in acute viral hepatitis and cirrhosis

1 reference

12 December 2020

10.2165/00003088-199223040-00005

Identifiers

DOI

1 reference

Dimensions Publication ID

8 August 2017

0 references

1 reference