(Q35463482)

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The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

blood–brain barrier

1 reference

based on heuristic

inferred from title

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1 reference

based on heuristic

inferred from title

author name string

Jenny L Pokorny

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

David Calligaris

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Shiv K Gupta

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Dennis O Iyekegbe

4

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Dustin Mueller

5

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Katrina K Bakken

6

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Brett L Carlson

7

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Mark A Schroeder

8

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Debra L Evans

9

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Zhenkun Lou

10

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Paul A Decker

11

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Jeanette E Eckel-Passow

12

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Vincenzo Pucci

13

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Bennett Ma

14

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Stuart D Shumway

15

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

William F Elmquist

16

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Nathalie Y R Agar

17

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Jann N Sarkaria

18

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

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publication date

21 January 2015

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Clinical Cancer Research

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

21

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

1916-1924

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

1 reference

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Targeting Wee1 for the treatment of pediatric high-grade gliomas

1 reference

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12 July 2018

Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging

1 reference

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12 July 2018

Brainstem gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas

1 reference

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12 July 2018

Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: results of a prospective pilot study.

1 reference

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12 July 2018

Selected protein monitoring in histological sections by targeted MALDI-FTICR in-source decay imaging

1 reference

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Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.

1 reference

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ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

1 reference

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12 July 2018

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Adult brainstem gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

RNAi screening of the kinome with cytarabine in leukemias

1 reference

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12 July 2018

Correlation between magnetic resonance imaging findings and histological diagnosis of intrinsic brainstem lesions in adults

1 reference

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12 July 2018

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

1 reference

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12 July 2018

Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Establishment, maintenance and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

1 reference

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The DNA Damage Response: Making It Safe to Play with Knives

1 reference

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12 July 2018

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401631

12 July 2018

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

1 reference

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12 July 2018

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

1 reference

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12 July 2018

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

1 reference

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12 July 2018

c-Myc accelerates S-phase and requires WRN to avoid replication stress

1 reference

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12 July 2018

Cell cycle, CDKs and cancer: a changing paradigm

1 reference

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12 July 2018

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines

1 reference

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12 July 2018

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

1 reference

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12 July 2018

Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor

1 reference

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12 July 2018

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

1 reference

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12 July 2018

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

1 reference

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Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy

1 reference

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26 September 2018

Identifiers

10.1158/1078-0432.CCR-14-2588

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

ResearchGate publication ID

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