(Q35470532)

English

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

transmembrane protein

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author name string

Shenyuan L Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Andriy V Yeromin

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Junjie Hu

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Anna Amcheslavsky

4

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Hongying Zheng

5

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Michael D Cahalan

6

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Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

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publication date

10 October 2011

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Europe PubMed Central

PubMed publication ID

8 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

8 August 2017

108

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Europe PubMed Central

PubMed publication ID

8 August 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

17838-17843

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

1 reference

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12 July 2018

The crystal structure of a voltage-gated sodium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Pore architecture of the ORAI1 store-operated calcium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Structural determinants of ion permeation in CRAC channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIMulating store-operated Ca(2+) entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Functional stoichiometry of the unitary calcium-release-activated calcium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Orai1 subunit stoichiometry of the mammalian CRAC channel pore.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Calcium signalling in lymphocyte activation and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Molecular basis of the CRAC channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Biochemical and functional characterization of Orai proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

CRACM1 multimers form the ion-selective pore of the CRAC channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Orai1 is an essential pore subunit of the CRAC channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

STIM1, an essential and conserved component of store-operated Ca2+ channel function

1 reference

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12 July 2018

Store-operated calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment

1 reference

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12 July 2018

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

1 reference

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12 July 2018

A store-operated calcium channel in Drosophila S2 cells

1 reference

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12 July 2018

Crystal structure and mechanism of a calcium-gated potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203763

12 July 2018

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores

1 reference

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A gating hinge in Na+ channels; a molecular switch for electrical signaling

1 reference

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26 September 2018

Identifiers

10.1073/PNAS.1114821108

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

2011PNAS..10817838Z

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

ResearchGate publication ID

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