(Q35536351)

English

Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia

scientific article published on 18 March 2015

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia (English)

1 reference

Europe PubMed Central

8 August 2017

ubiquitin-proteasome system

0 references

author name string

Kleiton Augusto Santos Silva

1

1 reference

Europe PubMed Central

8 August 2017

Jiangling Dong

2

1 reference

Europe PubMed Central

8 August 2017

Yanjun Dong

3

1 reference

Europe PubMed Central

8 August 2017

Yanlan Dong

4

1 reference

Europe PubMed Central

8 August 2017

Nestor Schor

5

1 reference

Europe PubMed Central

8 August 2017

David J Tweardy

6

1 reference

Europe PubMed Central

8 August 2017

Liping Zhang

7

1 reference

Europe PubMed Central

8 August 2017

William E Mitch

8

1 reference

Europe PubMed Central

8 August 2017

language of work or name

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publication date

18 March 2015

1 reference

Europe PubMed Central

8 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

8 August 2017

290

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Europe PubMed Central

8 August 2017

17

1 reference

Europe PubMed Central

8 August 2017

11177-11187

1 reference

Europe PubMed Central

8 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4409274/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma-induced cachexia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Mechanisms of cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Chemical probes that competitively and selectively inhibit Stat3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

C/EBPbeta regulates body composition, energy balance-related hormones and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Pathophysiologic response to severe burn injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Cachexia: a new definition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Two tales concerning skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

High-altitude illness and muscle physiology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

JAK/STAT-dependent gene regulation by cytokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Interleukin-6 depletion selectively improves hepatic insulin action in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Cachexia in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Identification of ubiquitin ligases required for skeletal muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

New cachexic factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Characterization of a cancer cachectic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Interleukin-6 induces skeletal muscle protein breakdown in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Comparison of protein synthesis and degradation in incubated and perfused muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Tumor necrosis factor induces skeletal muscle protein breakdown in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Control of food intake in cancer cachexia: a challenge and a tool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

12 July 2018

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

26 September 2018

Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

26 September 2018

Reversing cachexia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

26 September 2018

Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

26 September 2018

Characterization of 5'-regulatory region of human myostatin gene: regulation by dexamethasone in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409274

26 September 2018

Pancreatic cancer-induced cachexia is Jak2-dependent in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical results of long-term treatment with a low protein diet and a new amino acid preparation in patients with chronic uremia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/25787076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M115.641514

1 reference

Europe PubMed Central

8 August 2017

release_j3amdoephbd5jo4dii2c5j55qq

1 reference

https://api.fatcat.wiki/v0/release/j3amdoephbd5jo4dii2c5j55qq

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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