(Q35538543)

8 August 2017

title

A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability (English)

1 reference

sensory perception of pain

8 August 2017

main subject

1 reference

inferred from title

author name string

Claire Elizabeth Payne

1

1 reference

8 August 2017

Adam R Brown

2

1 reference

8 August 2017

Jonathon W Theile

3

1 reference

8 August 2017

Alexandre J C Loucif

4

1 reference

8 August 2017

Aristos J Alexandrou

5

1 reference

8 August 2017

Mathew D Fuller

6

1 reference

8 August 2017

John H Mahoney

7

1 reference

8 August 2017

Brett M Antonio

8

1 reference

8 August 2017

Aaron C Gerlach

9

1 reference

8 August 2017

David M Printzenhoff

10

1 reference

8 August 2017

Rebecca L Prime

11

1 reference

8 August 2017

Gillian Stockbridge

12

1 reference

8 August 2017

Anthony J Kirkup

13

1 reference

8 August 2017

Anthony W Bannon

14

1 reference

8 August 2017

Steve England

15

1 reference

8 August 2017

Mark L Chapman

16

1 reference

8 August 2017

Sharan Bagal

17

1 reference

8 August 2017

Rosemarie Roeloffs

18

1 reference

8 August 2017

Uma Anand

19

1 reference

8 August 2017

Praveen Anand

20

1 reference

8 August 2017

Peter J Bungay

21

1 reference

8 August 2017

Mark Kemp

22

1 reference

8 August 2017

Richard P Butt

23

1 reference

8 August 2017

Edward B Stevens

24

1 reference

8 August 2017

language of work or name

English

0 references

publication date

10 April 2015

1 reference

British Journal of Pharmacology

8 August 2017

published in

1 reference

8 August 2017

volume

172

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8 August 2017

issue

10

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8 August 2017

page(s)

2654-2670

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A common genetic variant within SCN10A modulates cardiac SCN5A expression

8 August 2017

cites work

1 reference

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27 July 2018

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Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats

27 July 2018

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27 July 2018

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27 July 2018

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Genetic variation in SCN10A influences cardiac conduction

27 July 2018

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27 July 2018

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27 July 2018

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Voltage-gated sodium channels: therapeutic targets for pain

27 July 2018

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Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.

27 July 2018

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Structural determinants of drugs acting on the Nav1.8 channel

27 July 2018

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Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms

27 July 2018

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The roles of sodium channels in nociception: Implications for mechanisms of pain

27 July 2018

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The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons

27 July 2018

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Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

27 July 2018

1 reference

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Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.

27 July 2018

1 reference

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Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats

27 July 2018

1 reference

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Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons.

27 July 2018

1 reference

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Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons

27 July 2018

1 reference

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Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.

27 July 2018

1 reference

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

27 July 2018

1 reference

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Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons

27 July 2018

1 reference

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A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat.

27 July 2018

1 reference

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PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade.

27 July 2018

1 reference

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Quantitative assessment of tactile allodynia in the rat paw

27 July 2018

1 reference

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

27 July 2018

1 reference

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Pain without nociceptors? Nav1.7-independent pain mechanisms.

27 July 2018

1 reference

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Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.

26 September 2018

1 reference

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Gain-of-function Nav1.8 mutations in painful neuropathy.

26 September 2018

1 reference

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A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

26 September 2018

1 reference

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Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.

26 September 2018

1 reference

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Sensory and motor complications of local anesthetics

26 September 2018

1 reference

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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

Small interfering RNA-mediated selective knockdown of Na(V)1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

Dorsal root ganglion neurones in culture: a model system for identifying novel analgesic targets?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

An automated flinch detecting system for use in the formalin nociceptive bioassay.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409913

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FBPH.13092

Are sodium channel blockers useless in peripheral neuropathic pain?

21 January 2018

1 reference

12 December 2020

Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states

1 reference

12 December 2020

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

1 reference

12 December 2020

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

1 reference

12 December 2020

Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.13092

1 reference

8 August 2017

1 reference

8 August 2017

1 reference