(Q35552648)

English

Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures

scientific article published on May 1, 2003

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures (English)

1 reference

Europe PubMed Central

8 August 2017

0 references

1 reference

10.1136/ARD.62.5.440

https://api.crossref.org/works/10.1136/ARD.62.5.440

24 December 2023

1 reference

10.1136/ARD.62.5.440

https://api.crossref.org/works/10.1136/ARD.62.5.440

24 December 2023

author name string

O. Elkayam

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

I. Yaron

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

I. Shirazi

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

R. Judovitch

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

D. Caspi

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

M. Yaron

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

language of work or name

0 references

publication date

1 May 2003

1 reference

Europe PubMed Central

8 August 2017

full work available at URL

https://ard.bmj.com/content/annrheumdis/62/5/440.full.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

https://europepmc.org/articles/PMC1754531

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

https://europepmc.org/articles/PMC1754531?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

https://doi.org/10.1136/ard.62.5.440

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695157

24 December 2023

https://syndication.highwire.org/content/doi/10.1136/ard.62.5.440

1 reference

10.1136/ARD.62.5.440

https://api.crossref.org/works/10.1136/ARD.62.5.440

24 December 2023

Annals of the Rheumatic Diseases

1 reference

Europe PubMed Central

8 August 2017

62

1 reference

Europe PubMed Central

8 August 2017

5

1 reference

Europe PubMed Central

8 August 2017

440-443

1 reference

Europe PubMed Central

8 August 2017

Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Modulation of inducible nitric oxide synthase activation by immunosuppressive drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Leflunomide: a review of its use in active rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

The role of nitric oxide in inflammation and immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Role of nitric oxide in the physiopathology of pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Leflunomide and malononitrilamides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Effects of leflunomide on immune responses and models of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Contribution of synovial mesenchymal cells to the pathogenesis of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

27 July 2018

Metalloproteases and inhibitors in arthritic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

26 September 2018

Anti-inflammatory effects of chemically modified tetracyclines by the inhibition of nitric oxide and interleukin-12 synthesis in J774 cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

26 September 2018

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1754531

26 September 2018

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights in the pathogenesis of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-Specific Inhibition of Inducible Nitric Oxide Synthase Activation by Leflunomide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirt

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide is a mediator of apoptosis in the rheumatoid joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue activation. XXI. Regulation of glycosaminoglycan metabolism by lymphocyte (CTAP-I) and platelet (CTAP-III) growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid inhibition of adjuvant arthritis synovial macrophage nitric oxide production: role of lipocortin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12695157

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/ARD.62.5.440

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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0 references

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