(Q35565904)

8 August 2017

title

How structural and physicochemical determinants shape sequence constraints in a functional enzyme (English)

1 reference

8 August 2017

Luciano A Abriata

1

1 reference

8 August 2017

Timothy Palzkill

series ordinal

2

1 reference

8 August 2017

Matteo Dal Peraro

series ordinal

3

1 reference

8 August 2017

language of work or name

English

0 references

publication date

23 February 2015

1 reference

8 August 2017

1 reference

8 August 2017

volume

10

1 reference

8 August 2017

issue

2

1 reference

8 August 2017

page(s)

e0118684

1 reference

Creative Commons Attribution 4.0 International

8 August 2017

copyright license

start time

23 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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12 July 2018

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Host-specific enzyme-substrate interactions in SPM-1 metallo-β-lactamase are modulated by second sphere residues

12 July 2018

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12 July 2018

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Capturing the mutational landscape of the beta-lactamase TEM-1.

12 July 2018

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12 July 2018

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Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world

12 July 2018

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Analyses of the effects of all ubiquitin point mutants on yeast growth rate

12 July 2018

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The spatial architecture of protein function and adaptation

12 July 2018

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Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution

12 July 2018

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Integrating sequence variation and protein structure to identify sites under selection

12 July 2018

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Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing

12 July 2018

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Fitness analyses of all possible point mutations for regions of genes in yeast

12 July 2018

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High-resolution mapping of protein sequence-function relationships

12 July 2018

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Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance

12 July 2018

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12 July 2018

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Evolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance

12 July 2018

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12 July 2018

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Rationally tuning the reduction potential of a single cupredoxin beyond the natural range

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Stability effects of mutations and protein evolvability

12 July 2018

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12 July 2018

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The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

How protein stability and new functions trade off

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Protein evolution constraints and model-based techniques to study them

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

The stability effects of protein mutations appear to be universally distributed

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Population genetics without intraspecific data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Testing for spatial clustering of amino acid replacements within protein tertiary structure.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Generality of the structurally constrained protein evolution model: assessment on representatives of the four main fold classes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

The 'evolvability' of promiscuous protein functions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Protein evolution with dependence among codons due to tertiary structure.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

POPS: A fast algorithm for solvent accessible surface areas at atomic and residue level

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Directed evolution of proteins by exon shuffling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

How enzymes adapt: lessons from directed evolution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Assessing the impact of secondary structure and solvent accessibility on protein evolution.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Amino acid sequence determinants of beta-lactamase structure and activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Protein-water interactions in MD simulations: POPS/POPSCOMP solvent accessibility analysis, solvation forces and hydration sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Quaternary structure constraints on evolutionary sequence divergence.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338278

Control of the Electronic Ground State on an Electron-Transfer Copper Site by Second-Sphere Perturbations

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0118684

A Conformational Flexibility Scale for Amino Acids in Peptides

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25706742

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sequence-function-stability relationships in proteins from datasets of functionally annotated variants: the case of TEM β-lactamases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25706742

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Site interdependence attributed to tertiary structure in amino acid sequence evolution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25706742

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0118684

1 reference

8 August 2017

0 references

1 reference

8 August 2017

1 reference