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Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
scientific article published on October 2003
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Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
review article
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Europe PubMed Central
title
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
main subject
DNA methylation
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author
Giuseppe Leone
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
Maria T Voso
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2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
Luciana Teofili
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
author name string
Michael Lübbert
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
language of work or name
English
1 reference
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publication date
1 October 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
published in
Clinical Immunology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
volume
109
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
page(s)
89-102
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
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Alterations of DNA methylation in hematologic malignancies
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
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Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation
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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
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CDKN2 (MTS1/p16INK4A) gene alterations in hematological malignancies
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7 January 2021
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Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation
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Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes?
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Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia
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Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia
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Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.
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Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia.
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Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations
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Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
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Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia
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Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis
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Detection of methylated ABL1 promoter in philadelphia-negative myeloproliferative disorders.
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JunB gene expression is inactivated by methylation in chronic myeloid leukemia
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
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Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance
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Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.
1 reference
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Crossref
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7 January 2021
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Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia
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Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma
1 reference
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Hypermethylation of P16ink4a and P15ink4b genes as a marker of disease in the follow-up of non-Hodgkin's lymphomas
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based on heuristic
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Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation
1 reference
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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Role of genetic and epigenetic changes in Burkitt lymphoma
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.
1 reference
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7 January 2021
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DNA methylation as a target for drug design
1 reference
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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
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7 January 2021
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Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment
1 reference
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Crossref
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7 January 2021
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Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors.
1 reference
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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
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Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells
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7 January 2021
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DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair
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Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2'-deoxycytidine
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Phase I study of arabinosyl-5-azacytidine (fazarabine) in adult acute leukemia and chronic myelogenous leukemia in blastic phase
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Changes in phenotypic expression in embryonic and adult cells treated with 5-azacytidine
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Molecular, cellular and animal pharmacology of 5-aza-2'-deoxycytidine
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Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
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DNA methyltransferases
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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inferred from DOI database lookup
Towards a pharmacology of DNA methylation
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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inferred from DOI database lookup
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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Evaluation of continuous infusion low-dose 5-azacytidine in the treatment of myelodysplastic syndromes
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Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.
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Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
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Continuous infusion of low-dose 5-Aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients
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Hypocellular myelodysplastic syndromes (MDS): new proposals.
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Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients.
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Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation
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Synergistic interactions between differentiation-inducing agents in inhibiting the proliferation of HL-60 human myeloid leukaemia cells in clonogenic micro assays
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https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9
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7 January 2021
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inferred from DOI database lookup
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1521-6616(03)00207-9
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
PubMed publication ID
14585280
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14585280
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
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