(Q35572372)

8 August 2017

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title

Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences (English)

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8 August 2017

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Pacifici GM

1

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8 August 2017

Viani A

series ordinal

2

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8 August 2017

publication date

1 December 1992

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Clinical Pharmacokinetics

8 August 2017

published in

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8 August 2017

volume

23

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8 August 2017

issue

6

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8 August 2017

page(s)

449-468

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8 August 2017

cites work

Tissue binding of drugs

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12 December 2020

Determination and prediction of tissue binding of prednisolone in the rabbit.

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12 December 2020

The clinical relevance of protein binding and tissue concentrations in antimicrobial therapy

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12 December 2020

Studies on the binding of benzodiazepines to human serum albumin by circular dichroism measurements

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12 December 2020

Subcellular distribution of digoxin-H3 in isolated guinea-pig and rat hearts

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12 December 2020

Diseases and Drug Protein Binding

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12 December 2020

Theophylline tissue partitioning and volume of distribution in normal and dietary-induced obese rats.

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12 December 2020

Tissue Fractionation in Neurobiochemistry: an Analytical Tool or a Source of Artifacts

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12 December 2020

Characterization of drug distribution and binding competition by two-chamber and multi-chamber distribution dialysis

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12 December 2020

Protein binding of chloroquine enantiomers and desethylchloroquine

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12 December 2020

Binding of drugs to human muscle

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12 December 2020

Effect of disease states on plasma protein binding of drugs.

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12 December 2020

Hydrophobic interactions responsible for unspecific binding of morphine-like drugs

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12 December 2020

Accumulation of amines in the isolated perfused rabbit lung

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12 December 2020

Subcellular distribution of styrene oxide in rat liver

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12 December 2020

Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs

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12 December 2020

The uptake and subcellular distribution of gold in rat liver cells after in vivo administration of sodium aurothiomalate

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12 December 2020

Subcellular distribution of deslanatoside c, ouabain and digitoxin in the heart and liver of conscious guinea pigs

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12 December 2020

Conformational changes in human serum albumin around the neutral pH from circular dichroic measurements

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12 December 2020

Drug protein binding and the nephrotic syndrome

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12 December 2020

Distribution volume related to body weight and protein binding

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12 December 2020

Binding of drugs to human skin: influencing factors and the role of tissue lipids

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12 December 2020

Bilirubin displaces furosemide from serum protein: the effect is greater in newborn infants than adult subjects

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12 December 2020

The binding of arsenazo III to cell components

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12 December 2020

Stereoselective protein binding of verapamil enantiomers

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12 December 2020

Binding of antibiotics to tissue homogenates.

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12 December 2020

Biochemical and Morphological Characterization of Subcellular Fractions Isolated from Rabbit Colon Muscle

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12 December 2020

The purification and biochemical characterization of bovine liver nuclear membranes.

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12 December 2020

Alteration of drug-protein binding in renal disease

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12 December 2020

Accumulation of 14 C-imipramine in isolated perfused rat lungs

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12 December 2020

Severity of cirrhosis and the relationship of alpha 1-acid glycoprotein concentration to plasma protein binding of lidocaine.

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12 December 2020

Tissue binding of warfarin

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12 December 2020

Interaction of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, an inhibitor of plasma protein binding in uraemia, with human albumin

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12 December 2020

Plasma protein binding of drugs in pregnancy

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12 December 2020

Stereoselective binding of disopyramide to human plasma protein

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12 December 2020

The disposition of propranolol. IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver

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12 December 2020

Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels

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12 December 2020

Protein binding methodology: comparison of equilibrium dialysis and frontal analysis chromatography in the study of salicylate binding

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12 December 2020

Factors affecting drug binding in plasma of elderly patients

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12 December 2020

Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate

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12 December 2020

Distribution of salicylate between neonatal and maternal serum at diffusion equilibrium

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12 December 2020

Effect of quinidine on the tissue binding of digoxin in guinea-pigs.

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12 December 2020

Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults

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12 December 2020

Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting

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12 December 2020

Binding of Diazepam, Salicylic Acid and Digitoxin to Albumin Isolated from Fetal and Adult Serum

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12 December 2020

Studies on the uptake and binding of propranolol by rat tissues

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12 December 2020

Tissue distribution and subcellular localization of bovine thioredoxin determined by radioimmunoassay

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12 December 2020

Protein binding of salicylate in uremic and normal plasma

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12 December 2020

Protein binding of drugs in plasma from patients with acute renal failure

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12 December 2020

Uptake, metabolism and efflux of methadone in "single pass" isolated perfused rabbit lungs

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12 December 2020

Clonazepam serum protein binding during development

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12 December 2020

The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein

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12 December 2020

Interactions of benzodiazepines with human serum albumin. Circular dichroism studies

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12 December 2020

Binding of quinidine in serum and heart from normal and anuric rats, and the significance for distribution

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12 December 2020

The binding of ibuprofen to plasma proteins

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12 December 2020

Subcellular distribution of pinazepam and its metabolite N-desmethyldiazepam in rat liver.

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12 December 2020

The interaction of barbiturates with serum albumin and its possible relation to their disposition and pharmacological actions

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12 December 2020

Absence of metabolism of morphine during accumulation by isolated perfused rabbit lung

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12 December 2020

Interaction of phenylbutazone with racemic phenprocoumon and its enantiomers in rats

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12 December 2020

Investigations on salicylate protein binding in newborns and infants.

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12 December 2020

26 Isolation and properties of the nuclear envelope

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12 December 2020

The disposition of propranolol. VII. The effects of saturable hepatic tissue uptake on drug clearance by the perfused rat liver

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12 December 2020

Chapter 14 Isolation of Plasma Membrane Vesicles from Animal Cells

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12 December 2020

Drug interactions involving the displacement of drugs from plasma protein and tissue binding sites

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12 December 2020

Uptake, Metabolism and Excretion of Desmethylimipramine and its Metabolites in the Isolated Perfused Rat Liver

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12 December 2020

Correlation between arginyl residue modification and benzodiazepine binding to human serum albumin.

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12 December 2020

Protein Binding of Cardiac Glycosides in Disease States

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12 December 2020

The "ultra-free" ultrafiltration technique compared with equilibrium dialysis for determination of unbound thiopental concentrations in serum.

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12 December 2020

Excretion of the uraemic metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human urine

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12 December 2020

Independent binding of ligands to human serum albumin

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12 December 2020

Altered plasma protein binding of drugs in thyroid disease

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12 December 2020

Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasma

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12 December 2020

Binding of non-steroid anti-inflammatory drugs and warfarin to liver tissue of rabbits in vitro

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12 December 2020

Isolation of rough and smooth microsomes from rat liver by means of a commercially available centrifuge

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12 December 2020

Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material

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12 December 2020

Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein

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12 December 2020

Intracellular binding and metabolism of imipramine and imipramine-N-oxide

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12 December 2020

Binding of imipramine to plasma proteins: effect of hyperlipoproteinemia

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12 December 2020

Influence of pH on the benzodiazepine-human serum albumin complex. Circular dichroism studies.

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12 December 2020

Comparison between in-vivo and in-vitro tissue-to-plasma unbound concentration ratios (Kp,f) of quinidine in rats

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12 December 2020

Binding of organic compounds to rat liver and lung

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12 December 2020

Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution

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12 December 2020

Studies on the Pharmacokinetic Function of the Lung with Special Reference to Lidocaine

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12 December 2020

Binding of furosemide to albumin isolated from human fetal and adult serum

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12 December 2020

The significance of plasma protein binding on the fetal/maternal distribution of drugs at steady-state

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12 December 2020

Quantitative and qualitative binding characteristics of disopyramide in serum from patients with decreased renal and hepatic function

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12 December 2020

Comparative uptake of quinine and quinidine in rat lung

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12 December 2020

Nuclear epoxide hydrolase in the human fetal and adult liver

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12 December 2020

Subcellular distribution of Δ9-tetrahydrocannabinol in rat brain

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12 December 2020

Analytical techniques for cell fractions. 8. Analytical differential centrifugation in angle-head rotors

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12 December 2020

Rapid determination of the concentration of unbound warfarin in human plasma.

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12 December 2020

A pressure ultrafiltration method for serum free drug determination. Comparison with equilibrium dialysis using normal and uraemic sera

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12 December 2020

Specific in vivo binding of neuroleptic drugs in rat brain

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12 December 2020

Plasma protein binding of furosemide in the elderly

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12 December 2020

3H-reserpine persistently bound "in vivo" to rat brain subcellular components: limited removal by peanut oil extraction

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12 December 2020

Interaction of benzodiazepine derivatives with bovine serum albumin-II. Circular dichroism studies

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12 December 2020

Uptake of propranolol by the lung and its displacement by other drugs: involvement of the alveolar macrophage

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12 December 2020

Stereoselective binding of propranolol in the elderly

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12 December 2020

Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat.

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12 December 2020

Potential Effect of the Plasma Proteins on Drug Distribution

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12 December 2020

Effect of age and sex on the plasma binding of acidic and basic drugs

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12 December 2020

The effect of ageing on plasma albumin and plasma protein binding of diazepam, salicylic acid and digitoxin in healthy subjects and patients with renal impairment

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12 December 2020

Optical studies of drug-protein complexes. IV. The interaction of warfarin and dicoumarol with human serum albumin.

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12 December 2020

The accumulation and distribution of dicumarol in rat liver slices

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12 December 2020

Binding of basic drugs to rat lung mitochondria

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12 December 2020

The effect of haemodialysis on the binding capacity of albumin

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12 December 2020

Effect of serum protein binding on pharmacokinetics and anticoagulant activity of phenprocoumon in rats

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12 December 2020

Clearance approaches in pharmacology.

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12 December 2020

A high-performance liquid chromatography assay for measuring integrated biphenyl metabolism by intact cells: its use with rat liver and human liver and kidney

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12 December 2020

Prediction of peak penicillin and cephalosporin concentrations in canine serum as derived from in vitro serum and tissue quantitative protein binding

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12 December 2020

A graphic method for the determination and presentation of binding parameters in a complex system

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12 December 2020

Interaction of propafenone enantiomers with human alpha 1-acid glycoprotein

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12 December 2020

Different binding of propranolol enantiomers to human alpha 1-acid glycoprotein

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12 December 2020

Enhancement of diphenylhydantoin binding by lipid extraction

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12 December 2020

Liver slices in dynamic organ culture. II. Anin vitrocellular technique for the study of integrated drug metabolism using human tissue

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12 December 2020

Analytical differential centrifugation: an analysis of the sedimentation properties of synaptosomes, mitochondria and lysosomes from rat brain homogenates.

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12 December 2020

Use of serum albumin microspheres as a reversible adsorbent for studying protein-small molecule interactions.

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12 December 2020

In vitro binding of metabolically activated [14C]-Ledakrin, or 1-nitro-9-14C-(3′-dimethylamino-n-propylamino) acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular fractions isolated from rat liver and HeLa cells

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12 December 2020

Direct and indirect determination of binding constants of drug-protein complexes with microparticles

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12 December 2020

The binding of organic ions by proteins

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12 December 2020

Microscale ultrafiltration technique for determining free drug in 50-microL serum samples.

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12 December 2020

Chlorphentermine uptake by isolated perfused rabbit lung

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12 December 2020

Comparison of circular dichrometers: normal and difference circular dichroism measurements

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12 December 2020

Binding of theophylline in human serum determined by ultrafiltration and equilibrium dialysis

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12 December 2020

Subcellular distribution of etorphine in rat brain and evidence for in vitro stereospecific binding

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12 December 2020

A technique for miniature dialysis

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12 December 2020

Disease-induced changes in the plasma binding of basic drugs

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12 December 2020

Kinetic studies of the tissue binding tendency of the new vasodilator pildralazine

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12 December 2020

Effects of development, aging, and renal and hepatic insufficiency as well as hemodialysis on the plasma concentrations of albumin and alpha 1-acid glycoprotein: implications for binding of drugs.

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12 December 2020

Effect of Sulfadimethoxine on Thiopental Distribution and Elimination in Rats

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12 December 2020

Improved Stability of Proteins Immobilized in Microparticles Prepared by a Modified Emulsion Polymerization Technique

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12 December 2020

Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease

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12 December 2020

Kinetics of gentamicin accumulation in subcellular structures of the mouse kidney

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12 December 2020

Chapter 15 Rapid Isolation of Nuclear Envelopes from Rat Liver

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12 December 2020

Pharmacokinetic consequences of drug displacement from blood and tissue proteins

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12 December 2020

Effect of temperature on the binding of salicylate by human serum albumin

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12 December 2020

Studies on plasma protein binding of carbamazepine

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12 December 2020

Protein binding and drug clearance

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12 December 2020

Concentration of (+/-)-propranolol in isolated, perfused lungs of rat

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12 December 2020

Subcellular localization of cis-dichlorodiammineplatinum(II) in rat kidney and liver

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12 December 2020

Sephadex G-25 quantitative estimation of free bilirubin potential in jaundiced newborn infants sera: a guide to the prevention of kernicterus

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12 December 2020

Plasma protein binding of salicylic acid, phenytoin, chlorpromazine, propranolol and pethidine using equilibrium dialysis and ultracentrifugation.

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12 December 2020

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates

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12 December 2020

Protein Binding and Kinetics of Drugs in Liver Diseases

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12 December 2020

Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications

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12 December 2020

Binding of drugs to tissues

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12 December 2020

The binding of antibiotics to serum proteins

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12 December 2020

The uptake and subcellular distribution of radio-labelled metabolites of digitoxin in the guinea-pig isolated perfused heart

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12 December 2020

The effect of chlorpromazine on the uptake and efflux of paraquat in rat lung slices

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12 December 2020

Lung accumulation of some beta-adrenoceptor antagonists [proceedings]

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12 December 2020

Uptake and metabolism of chlorpromazine by rat and rabbit lungs

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12 December 2020

The binding of thiopental to serum proteins determined by ultrafiltration and equilibrium dialysis.

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12 December 2020

Distribution of clozapine in the rat: localization in lung

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12 December 2020

Plasma and Tissue Binding Considerations in Drug Disposition

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12 December 2020

Characterization of the binding of benzodiazepines to human serum albumin

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12 December 2020

Furosemide binding to human albumin and plasma of nephrotic children

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12 December 2020

Binding of drugs in serum, blood cells and tissues of rabbits with experimental acute renal failure

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12 December 2020

Plasma protein binding of drugs in the elderly

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12 December 2020

Interindividual variability in the concentrations of albumin and alpha-1-acid glycoprotein in patients with renal or liver disease, newborns and healthy subjects: implications for binding of drugs

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12 December 2020

Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α1Acid Glycoprotein

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12 December 2020

Serum protein binding of drugs and bilirubin in newborn infants and their mothers.

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12 December 2020

Stereoselective plasma protein binding of ibuprofen enantiomers

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12 December 2020

Properties of graphical representations of multiple classes of binding sites

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12 December 2020

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

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12 December 2020

Analytical study of microsomes and isolated subcellular membranes from rat liver VIII. Subfractionation of preparations enriched with plasma membranes, outer mitochondrial membranes, or Golgi complex membranes

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12 December 2020

Binding of drugs to muscle tissue: dependence on drug concentration and lipid content of tissue

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12 December 2020

Human and dog, but not rat, isolated hepatocytes have decreased foreign compound-metabolizing activity compared to liver slices.

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12 December 2020

A multichamber equilibrium dialysis apparatus

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12 December 2020

In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

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12 December 2020

A study of factors influencing drug disposition in chronic liver disease, using the model drug (+)-propranolol

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12 December 2020

Interaction of benzodiazepine derivatives with bovine serum albumin-I Gel filtration studies

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12 December 2020

Cricular dichroism studies of drug-protein complexes

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12 December 2020

The binding of drugs to plasma proteins from patients with poor renal function

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12 December 2020

Plasma protein binding of drugs in pregnancy and in neonates

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12 December 2020

Plasma protein binding of dicloxacillin: effects of age and diseases

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12 December 2020

The relation between circulating and tissue concentrations of salicylate in the mouse in vivo.

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12 December 2020

Subcellular distribution of weak acids and bases in adrenal medulla

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12 December 2020

Binding of diffusible molecules by macromolecules: rapid measurement by rate of dialysis

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12 December 2020

Interaction of pirprofen enantiomers with human serum albumin

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12 December 2020

Subcellular distribution of high affinity [3H]imipramine binding and [3H]serotonin uptake in rat brain

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12 December 2020

Plasma and tissue protein binding of drugs in pharmacokinetics

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12 December 2020

Beta-adrenergic receptor ligand binding by rabbit lung.

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12 December 2020

Importance of tissue and plasma binding in determining the retention of norchlorcyclizine and norcyclizine in man, dog and rat.

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12 December 2020

A rapid and sensitive method for measuring the binding of radioactive ligands to proteins

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12 December 2020

Clinical pharmacokinetics in infants and children

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12 December 2020

The concentration of basic and acidic compounds in guinea-pig lung [proceedings]

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12 December 2020

Binding of drugs to human serum albumin:XI. The specificity of three binding sites as studied with albumin immobilized in microparticles

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12 December 2020

Lidocaine plasma protein binding.

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12 December 2020

Hepatic uptake of propranolol.

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12 December 2020

Species differences in plasma binding and tissue uptake of 3H-digitoxin. A comparative study in rats and mice in vivo and in vitro

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12 December 2020

Preparation and characterization of subcellular fractions from the head kidney of the Northern pike (Esox lucius), with particular emphasis on xenobiotic-metabolizing enzymes

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12 December 2020

Measurement of protein-binding phenomena by gel filtration

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12 December 2020

Serum protein binding of furosemide in newborn infants and children

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12 December 2020

PHYSIOLOGICAL DISPOSITION OF GUANETHIDINE IN THE RAT AND ITS UPTAKE BY HEART SLICES

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12 December 2020

Optical studies of drug-protein complexes. 3. Interaction of flufenamic acid and other N-arylanthranilates with serum albumin

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12 December 2020

Techniques for plasma protein binding of demethylchlorimipramine

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12 December 2020

10.2165/00003088-199223060-00005

Identifiers

DOI

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Dimensions Publication ID

8 August 2017

1021688587

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