(Q35572471)

8 August 2017

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title

The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection (English)

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8 August 2017

Christoph A Klein

1

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8 August 2017

1 January 2003

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Advances in Cancer Research

8 August 2017

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8 August 2017

89

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8 August 2017

35-67

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Unknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients

8 August 2017

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The age distribution of cancer and a multi-stage theory of carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Metastasis: objections to the same-gene model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

1 reference

7 January 2021

Proliferation of prostate cancer cells in the bone marrow predicts recurrence in patients with localized prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Occult tumor cells in bone marrow of patients with locoregionally restricted ovarian cancer predict early distant metastatic relapse.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

[Tumor cell dissemination in bone marrow and peritoneal cavity. An immunocytochemical study of patients with stomach or colorectal carcinoma]

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Mutation selection and the natural history of cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Dissemination and growth of cancer cells in metastatic sites

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Self-organization, complexity and chaos: the new biology for medicine.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Polychemotherapy for early breast cancer: an overview of the randomised clinical trials with quality-adjusted survival analysis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The presence of bone marrow cytokeratin-immunoreactive cells does not predict outcome in gastric cancer patients

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic significance of breast cancer axillary lymph node micrometastases assessed by two special techniques: reevaluation with longer follow-up

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

1 reference

7 January 2021

Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Metastasis: the role of chance in malignancy

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

A genetic model for colorectal tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Metastasis results from preexisting variant cells within a malignant tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Epithelial cells in bone marrow of breast cancer patients at time of primary surgery: clinical outcome during long-term follow-up

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Progressive evolution: Aspirational thinking

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

I. The Results of Radical Operations for the Cure of Carcinoma of the Breast

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Gene expression in inherited breast cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Minimal residual disease in gastric cancer: evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Telomerase activity in human breast tumors

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Coping with complexity. multivariate analysis of tumor karyotypes

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Early lymphatic tumor cell dissemination in pancreatic cancer: frequency and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic significance of bone marrow micrometastases in patients with gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The biology and analysis of single disseminated tumour cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Combined transcriptome and genome analysis of single micrometastatic cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Foulds' dangerous idea revisited: the multistep development of tumors 40 years later.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic value of bone marrow biopsy in operable breast cancer patients at the time of initial diagnosis: Results of a 20-year median follow-up

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic relevance of immunohistochemically detected lymph node micrometastasis in patients with gastric carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Cytokeratin-positive cells in bone marrow in comparison with other prognostic factors in colon carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The prognostic impact of cytokeratin-positive cells in bone marrow of patients with localized prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Clinical significance of occult micrometastasis lymph nodes from patients with early gastric cancer who died of recurrence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

A unified theory of carcinogenesis based on order-disorder transitions in DNA structure as studied in the human ovary and breast

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Circulating tumor cells in the peripheral blood and bone marrow of patients with ovarian carcinoma do not predict prognosis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Connecting chromosomes, crisis, and cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Occult axillary node metastases in breast cancer: their detection and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Sequential immunotyping and genotyping of tumor cells in bone marrow of cancer patients: a model study

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Detection of genetic alterations in micrometastatic cells in bone marrow of cancer patients by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Occult axillary lymph node metastases in "node-negative" breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma: frequency, associated tumor characteristics, and impact on prognosis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The clonal evolution of tumor cell populations

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Detection and clinical importance of micrometastatic disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Immunohistochemical assessment of individual tumor cells in lymph nodes of patients with non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Bone marrow micrometastasis might not be a short-term predictor of survival in early stages non-small cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

A molecular signature of metastasis in primary solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Detection of micrometastases in patients with primary breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

How many mutations are required for tumorigenesis? Implications from human cancer data

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Use of monoclonal antibody MBr1 to detect micrometastases in bone marrow specimens of breast cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization, and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Micrometastatic tumour cells in bone marrow of patients with gastric cancer: Methodological aspects of detection and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Metastasis: objections to the same-gene model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Outcome after invasive local recurrence in patients with ductal carcinoma in situ of the breast

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Revision of the American Joint Committee on Cancer staging system for breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Mammographically detected ductal carcinoma in situ of the breast treated with breast-conserving surgery and definitive breast irradiation: long-term outcome and prognostic significance of patient age and margin status

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

SCOMP is superior to degenerated oligonucleotide primed-polymerase chain reaction for global amplification of minute amounts of DNA from microdissected archival tissue samples

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The onset and extent of genomic instability in sporadic colorectal tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Micrometastatic p53-positive cells in the lymph nodes of early stage epithelial ovarian cancer: prognostic significance.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Epithelial tumour cells in bone marrow of patients with pancreatic carcinoma detected by immunocytochemical staining

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Epithelial cells in bone marrow of oesophageal cancer patients: a significant prognostic factor in multivariate analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

How many mutations in a cancer?

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

The mutation rate and cancer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

A gene-expression signature as a predictor of survival in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Genetic alterations during colorectal-tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Disseminated cytokeratin positive tumor cells in the bone marrow of patients with prostate cancer: detection and prognostic value

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Micrometastases of bone marrow in localized prostate cancer: correlation with established risk factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Immunomagnetic enrichment and detection of micrometastases in colorectal cancer: correlation with established clinical parameters

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

Retinoblastoma tumor suppressor and genome stability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2803%2901002-9

7 January 2021

10.1016/S0065-230X(03)01002-9

Identifiers

DOI

1 reference

8 August 2017

1 reference

PubMed ID

14587870