(Q35575706)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

0 references

7

1 reference

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28 January 2020

author name string

Lili Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Roberto Calcedo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Peter Bell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Jianping Lin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Rebecca L Grant

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Don L Siegel

6

1 reference

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28 January 2020

publication date

8 June 2011

1 reference

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28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

22

1 reference

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28 January 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

1389-1401

1 reference

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describes a project that uses

28 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3225046/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Hemophilia gene therapy: a Holy Grail found

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Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy

27 July 2018

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27 July 2018

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The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques

27 July 2018

1 reference

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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

27 July 2018

1 reference

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AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

27 July 2018

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AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice

27 July 2018

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Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice.

27 July 2018

1 reference

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HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis

27 July 2018

1 reference

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Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential

27 July 2018

1 reference

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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

27 July 2018

1 reference

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Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

27 July 2018

1 reference

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

27 July 2018

1 reference

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Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer

27 July 2018

1 reference

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Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225046

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225046

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225046

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225046

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

27 July 2018

1 reference

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Adeno-associated viruses undergo substantial evolution in primates during natural infections

27 July 2018

1 reference

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

27 July 2018

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27 July 2018

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Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain

27 July 2018

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A standard for calibration and shading correction of a fluorescence microscope

27 July 2018

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Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo

27 July 2018

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27 July 2018

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26 September 2018

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Systematic evaluation of AAV vectors for liver directed gene transfer in murine models.

26 September 2018

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The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice

26 September 2018

1 reference

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26 September 2018

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Effect of gene therapy on visual function in Leber's congenital amaurosis

26 September 2018

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26 September 2018

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26 September 2018

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Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver.

26 September 2018

1 reference

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Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

26 September 2018

1 reference

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Clades of Adeno-associated viruses are widely disseminated in human tissues.

26 September 2018

1 reference

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Route of administration determines induction of T-cell-independent humoral responses to adeno-associated virus vectors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225046

Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver.

26 September 2018

1 reference

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In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.

26 September 2018

1 reference

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26 September 2018

Identifiers

DOI

10.1089/HUM.2011.031

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21476868%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

21476868

1 reference