(Q35578573)

9 August 2017

title

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target (English)

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9 August 2017

1 reference

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Jiarong Li

1

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9 August 2017

Andrew C Karaplis

2

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9 August 2017

Dao C Huang

3

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9 August 2017

Peter M Siegel

4

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9 August 2017

Anne Camirand

5

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9 August 2017

Xian Fang Yang

6

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9 August 2017

William J Muller

7

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9 August 2017

Richard Kremer

8

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9 August 2017

language of work or name

English

0 references

publication date

7 November 2011

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Journal of Clinical Investigation

9 August 2017

published in

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9 August 2017

volume

121

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9 August 2017

issue

12

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9 August 2017

page(s)

4655-4669

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describes a project that uses

9 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3225988/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy

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Lessons in signaling and tumorigenesis from polyomavirus middle T antigen

12 July 2018

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Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein

12 July 2018

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Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions.

12 July 2018

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New insights on the role of CXCR4 in cancer metastasis

12 July 2018

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Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation

12 July 2018

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PTHrP and tumorigenesis: is there a role in prognosis?

12 July 2018

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Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B.

12 July 2018

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Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells.

12 July 2018

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Exploiting the PI3K/AKT pathway for cancer drug discovery

12 July 2018

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Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from MDA-MB-231.

12 July 2018

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CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12.

12 July 2018

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Genes that mediate breast cancer metastasis to lung

12 July 2018

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Functions of CXCL12 and CXCR4 in breast cancer

12 July 2018

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Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells

12 July 2018

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Silencing of CXCR4 blocks breast cancer metastasis

12 July 2018

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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

12 July 2018

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Tumor-stroma interactions

12 July 2018

1 reference

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Direct evidence that PTHrP expression promotes prostate cancer progression in bone.

12 July 2018

1 reference

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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

12 July 2018

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Molecular characterization of the tumor microenvironment in breast cancer

12 July 2018

1 reference

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Mechanisms of bone metastasis

12 July 2018

1 reference

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The complexity of parathyroid hormone-related protein signalling.

12 July 2018

1 reference

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Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

A multigenic program mediating breast cancer metastasis to bone

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Metastasis to bone: causes, consequences and therapeutic opportunities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

PTHrP: novel roles in skeletal biology

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Involvement of chemokine receptors in breast cancer metastasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Expression and regulation of parathyroid hormone-related peptide in normal and malignant melanocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

ras Activation of human prostate epithelial cells induces overexpression of parathyroid hormone-related peptide.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Parathyroid hormone-related protein is required for tooth eruption

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Parathyroid hormone-related protein and hypercalcemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

All major lung cancer cell types produce parathyroid hormone-like protein: heterogeneity assessed by high performance liquid chromatography

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Parathyroid hormone-related protein as a growth regulator of prostate carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225988

Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer

26 September 2018

1 reference

12 December 2020

Parathyroid hormone related protein in breast cancers of widely varying prognosis

1 reference

12 December 2020

Parathyroid hormone-related protein and life expectancy in hypercalcemic cancer patients

1 reference

12 December 2020

Expression of parathyroid hormone-related peptide (PTHrP) in gastric tumours

1 reference

12 December 2020

The expression of parathyroid hormone-related protein in human breast cancer with skeletal metastases

1 reference

12 December 2020

Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development

1 reference

12 December 2020

Parathyroid-hormone-related peptide in hematologic malignancies

1 reference

12 December 2020

Parathyroid hormone-related protein in hypercalcaemia associated with haematological malignancy

1 reference

12 December 2020

Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression

1 reference

12 December 2020

Parathyroid hormone-related protein in patients with primary breast cancer and eucalcemia

1 reference

12 December 2020

Clinicopathological implications of parathyroid hormone-related protein in human colorectal tumours

1 reference

12 December 2020

Increased serum and urinary levels of a parathyroid hormone-related protein COOH terminus in non-small cell lung cancer patients

1 reference

12 December 2020

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

1 reference

12 December 2020

Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia

1 reference

12 December 2020

Parathyroid hormone-related peptide and survival of patients with cancer and hypercalcemia

1 reference

12 December 2020

Immunohistologic evaluation of parathyroid hormone-related protein in human lung cancer and normal tissue with newly developed monoclonal antibody

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI46134

1 reference

9 August 2017

1 reference

9 August 2017

1 reference