(Q35589926)

9 August 2017

1 reference

title

Chemical and Structural Aspects of Ebola Virus Entry Inhibitors (English)

1 reference

9 August 2017

main subject

Orthoebolavirus zairense

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author name string

Elisabeth K Nyakatura

series ordinal

1

1 reference

9 August 2017

Julia C Frei

series ordinal

2

1 reference

9 August 2017

Jonathan R Lai

series ordinal

3

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9 August 2017

publication date

11 December 2014

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9 August 2017

published in

ACS Infectious Diseases

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9 August 2017

volume

1

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9 August 2017

issue

1

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9 August 2017

page(s)

42-52

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus

9 August 2017

cites work

1 reference

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12 July 2018

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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus

12 July 2018

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An update on the use of antibodies against the filoviruses

12 July 2018

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Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail

12 July 2018

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C-peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: effects of conjugation to cholesterol and side chain-side chain crosslinking

12 July 2018

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Role of electrostatic repulsion in controlling pH-dependent conformational changes of viral fusion proteins

12 July 2018

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FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

12 July 2018

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Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry.

12 July 2018

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TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine

12 July 2018

1 reference

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Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe

12 July 2018

1 reference

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Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection

12 July 2018

1 reference

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Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG

12 July 2018

1 reference

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Cathepsin B & L are not required for ebola virus replication

12 July 2018

1 reference

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Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein

12 July 2018

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Synthesized peptide inhibitors of HIV-1 gp41-dependent membrane fusion

12 July 2018

1 reference

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Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

12 July 2018

1 reference

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Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Crystal Structure of the Marburg Virus GP2 Core Domain in Its Postfusion Conformation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Structural basis for differential neutralization of ebolaviruses

12 July 2018

1 reference

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Filovirus entry: a novelty in the viral fusion world

12 July 2018

1 reference

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Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection

12 July 2018

1 reference

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Filovirus entry into cells - new insights

12 July 2018

1 reference

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Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease.

12 July 2018

1 reference

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Ebola virus entry requires the host-programmed recognition of an intracellular receptor

12 July 2018

1 reference

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Marburg virus glycoprotein GP2: pH-dependent stability of the ectodomain α-helical bundle

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences

12 July 2018

1 reference

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Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

A shared structural solution for neutralizing ebolaviruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Reston ebolavirus in humans and animals in the Philippines: a review

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: stability and pH effects

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

A new Ebola virus nonstructural glycoprotein expressed through RNA editing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Identification of a small-molecule entry inhibitor for filoviruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

12 July 2018

Ebola haemorrhagic fever

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

C-type lectins do not act as functional receptors for filovirus entry into cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

12 July 2018

1 reference

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Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner

12 July 2018

1 reference

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Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

12 July 2018

1 reference

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Potent Inhibition of HIV‐1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis

12 July 2018

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Recent advances in Ebolavirus vaccine development

12 July 2018

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A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

12 July 2018

1 reference

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Inhibition of protein-protein interactions using designed molecules

12 July 2018

1 reference

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Ebolavirus glycoprotein structure and mechanism of entry

12 July 2018

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A broad-spectrum antiviral targeting entry of enveloped viruses

12 July 2018

1 reference

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The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding

12 July 2018

1 reference

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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

The mechanism of Axl-mediated Ebola virus infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Modulation of virion incorporation of Ebolavirus glycoprotein: effects on attachment, cellular entry and neutralization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebola virus: unravelling pathogenesis to combat a deadly disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion intermediate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Covalent modifications of the ebola virus glycoprotein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Biosynthesis and role of filoviral glycoproteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

The pathogenesis of Ebola hemorrhagic fever

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Functional importance of the coiled-coil of the Ebola virus glycoprotein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Epitopes involved in antibody-mediated protection from Ebola virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Ebola virus can be effectively neutralized by antibody produced in natural human infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Marburg and Ebola hemorrhagic fevers: does the primary course of infection depend on the accessibility of organ-specific macrophages?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Biochemical analysis of the secreted and virion glycoproteins of Ebola virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Processing of the Ebola virus glycoprotein by the proprotein convertase furin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

A system for functional analysis of Ebola virus glycoprotein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Beneficial effect of new thiol protease inhibitors, epoxide derivatives, on dystrophic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Persistent immune responses after Ebola virus infection.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426353

26 September 2018

Identifiers

DOI

10.1021/ID500025N

1 reference

9 August 2017

1 reference

9 August 2017

1 reference