(Q35593939)

9 August 2017

1 reference

title

The therapeutic potential of neuronal KCNQ channel modulators (English)

1 reference

9 August 2017

Valentin K Gribkoff

1

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9 August 2017

language of work or name

English

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publication date

1 December 2003

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Expert Opinion on Therapeutic Targets

9 August 2017

published in

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9 August 2017

volume

7

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9 August 2017

issue

6

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9 August 2017

page(s)

737-748

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M-channels: neurological diseases, neuromodulation, and drug development.

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Neuronal KCNQ potassium channels: physiology and role in disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ potassium channels: physiology, pathophysiology, and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

A potassium channel mutation in neonatal human epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

An assessment of the present and future roles of non-ligand gated ion channel modulators as CNS therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Potassium channels as anti-epileptic drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

High throughput electrophysiology: new perspectives for ion channel drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Role of glial K(+) channels in ontogeny and gliosis: a hypothesis based upon studies on Müller cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Potassium channels in gastrointestinal smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Potassium channels, proliferation and G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The voltage-gated potassium channels and their relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Potassium channels and erectile dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Maxi-K potassium channels: form, function, and modulation of a class of endogenous regulators of intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Physiological and pathophysiological roles of ATP-sensitive K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Active dendrites, potassium channels and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Potassium channel openers: therapeutic potential in cardiology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ4 channel activation by BMS-204352 and retigabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The sodium-activated potassium channel is encoded by a member of the Slo gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

ATPase activity of the sulfonylurea receptor: a catalytic function for the KATP channel complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Age-dependent modulation of hippocampal excitability by KCNQ-channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Novel anticonvulsant medications in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Molecular correlates of the M-current in cultured rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Anticonvulsants in central pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Central hyperexcitability in chronic musculoskeletal pain: a conceptual breakthrough with multiple clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Voltage-gated potassium channels: from hyperexcitability to excitement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

An experimental model of migraine with aura: cortical hypoperfusion following spreading depression in the awake and freely moving rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Experimental approaches to age-related cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Scopolamine model of dementia: electroencephalogram findings and cognitive performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Pharmacologic modelling of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

The physiology and pharmacology of hippocampal formation theta rhythms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

Central effects of muscarinic agonists and antagonists on hippocampal theta rhythm and blood pressure in the anaesthetised rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.6.737

21 January 2018

Identifiers

DOI

10.1517/14728222.7.6.737

1 reference

9 August 2017

1 reference