(Q35597936)

9 August 2017

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title

Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside (English)

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9 August 2017

Syed R Husain

1

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9 August 2017

Raj K Puri

series ordinal

2

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9 August 2017

publication date

1 October 2003

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Journal of Neuro-Oncology

9 August 2017

published in

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9 August 2017

volume

65

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9 August 2017

issue

1

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9 August 2017

page(s)

37-48

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Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

9 August 2017

cites work

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12 December 2020

Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.

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12 December 2020

Mutation and functional analysis of IL-13 receptors in human malignant glioma cells

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12 December 2020

Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft.

1 reference

12 December 2020

The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway

1 reference

12 December 2020

Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts

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12 December 2020

Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.

1 reference

12 December 2020

Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.

1 reference

12 December 2020

Non-cytotoxic therapies for malignant gliomas

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12 December 2020

Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).

1 reference

12 December 2020

Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain

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12 December 2020

Characterization and comparison of the interleukin 13 receptor with the interleukin 4 receptor on several cell types

1 reference

12 December 2020

Pretargeted adjuvant radioimmunotherapy with yttrium-90-biotin in malignant glioma patients: a pilot study

1 reference

12 December 2020

Immunotoxins for brain tumor therapy.

1 reference

12 December 2020

Interleukin-13 receptor as a unique target for anti-glioblastoma therapy

1 reference

12 December 2020

Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice

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12 December 2020

The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1

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12 December 2020

IL-4 and IL-13 exhibit comparable abilities to reduce pyrogen-induced expression of procoagulant activity in endothelial cells and monocytes

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12 December 2020

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein

1 reference

12 December 2020

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

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12 December 2020

Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin.

1 reference

12 December 2020

Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway

1 reference

12 December 2020

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

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12 December 2020

A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4

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12 December 2020

Immunotoxins in cancer therapy

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12 December 2020

Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas.

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12 December 2020

In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice

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12 December 2020

Reoperation in recurrent high-grade gliomas: literature review of prognostic factors and outcome

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12 December 2020

Cytokine and cytokine receptor mRNA expression in human glioblastomas: evidence of Th1, Th2 and Th3 cytokine dysregulation.

1 reference

12 December 2020

Modulation of interleukin (IL)-13 binding and signaling by the gammac chain of the IL-2 receptor

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12 December 2020

Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT.

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12 December 2020

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

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12 December 2020

Long-term survival after gene therapy for a recurrent glioblastoma

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12 December 2020

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

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12 December 2020

Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor in advanced brain tumor patients: preliminary study

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12 December 2020

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy.

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12 December 2020

Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain

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12 December 2020

Interleukin 13 is a B cell stimulating factor

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12 December 2020

Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results

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12 December 2020

Potential of gene therapy for brain tumors

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12 December 2020

cDNA cloning and characterization of the human interleukin 13 receptor alpha chain

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12 December 2020

Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein

1 reference

12 December 2020

Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

1 reference

12 December 2020

Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells

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12 December 2020

Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain

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12 December 2020

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes

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12 December 2020

Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

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12 December 2020

Recombinant toxins as novel therapeutic agents

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12 December 2020

Fibroblast growth factor receptor (FGFR) 4 correlated with the malignancy of human astrocytomas

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12 December 2020

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

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12 December 2020

New strategy developments in brain tumor therapy.

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12 December 2020

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.

1 reference

12 December 2020

The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor

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12 December 2020

Preclinical studies with IL-13PE38QQR for therapy of malignant glioma.

1 reference

12 December 2020

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy

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12 December 2020

Identifiers

DOI

10.1023/A:1026242432647

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Dimensions Publication ID

9 August 2017

1025543248

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