(Q35607526)

9 August 2017

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title

Bone-specific drug delivery systems: approaches via chemical modification of bone-seeking agents (English)

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9 August 2017

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Hideki Hirabayashi

1

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9 August 2017

Jiro Fujisaki

series ordinal

2

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9 August 2017

publication date

1 January 2003

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Clinical Pharmacokinetics

9 August 2017

published in

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9 August 2017

volume

42

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9 August 2017

issue

15

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9 August 2017

page(s)

1319-1330

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Cancer therapy using bone-seeking isotopes.

9 August 2017

cites work

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12 December 2020

Diphosphonates: History and mechanisms of action

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12 December 2020

Bisphosphonates and tetracycline: experimental models for their evaluation in calcium-related disorders

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Bisphosphonate conjugation to proteins as a means to impart bone affinity

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Structural requirements for bisphosphonate actions in vitro

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Mode of administration-dependent pharmacokinetics of bisphosphonates and bioavailability determination.

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Osteoporosis: the need for comprehensive treatment guidelines

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Uptake by Bone of Pyrophosphate, Diphosphonates and their Technetium Derivatives

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12 December 2020

Treatment of Paget's disease of bone

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Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. III: Pharmacokinetics and targeting characteristics of osteotropic carboxyfluorescein

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12 December 2020

Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat

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12 December 2020

Samarium-153-EDTMP biodistribution and dosimetry estimation

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12 December 2020

Bisphosphonates: a review of their pharmacokinetic properties

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12 December 2020

Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone

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12 December 2020

Novel drug delivery system to bone using acidic oligopeptide: pharmacokinetic characteristics and pharmacological potential

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12 December 2020

Morphological and physiological considerations in a new concept of calcium transport in bone

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12 December 2020

Apatite cement containing cis-diamminedichloroplatinum implanted in rabbit femur for sustained release of the anticancer drug and bone formation

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12 December 2020

Healthcare use among U.S. women aged 45 and older: total costs and costs for selected postmenopausal health risks.

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12 December 2020

The Use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women

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12 December 2020

Dose-dependent pharmacokinetics and disposition of bisphosphonic prodrug of diclofenac based on osteotropic drug delivery system (ODDS).

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12 December 2020

Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterials

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12 December 2020

Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate.

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12 December 2020

Pathogenesis of osteoporosis and challenges for drug delivery

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12 December 2020

The uptake of clodronate (dichloromethylene bisphosphonate) by macrophages in vivo and in vitro

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12 December 2020

Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model

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12 December 2020

Structure-activity relationships (SAR) of hydroxyapatite-binding molecules

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12 December 2020

Targeted delivery of antineoplastic agent to bone: biodistribution studies of technetium-99m-labeled gem-bisphosphonate conjugate of methotrexate

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12 December 2020

Selective delivery of estradiol to bone by aspartic acid oligopeptide and its effects on ovariectomized mice

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12 December 2020

Bone bonding in bioactive glass ceramics combined with a new synthesized agent TAK-778.

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12 December 2020

The menopause: benefits and risks of estrogen-progestogen replacement therapy.

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12 December 2020

Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix

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12 December 2020

In vivo-in vitro study of biodegradable and osteointegrable gentamicin bone implants.

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12 December 2020

The treatment of hypercalcaemia of malignancy

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12 December 2020

Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis

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12 December 2020

Systemic metabolic radiotherapy with samarium-153 EDTMP for the treatment of painful bone metastasis.

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12 December 2020

Effect of 17beta-estradiol-bisphosphonate conjugates, potential bone-seeking estrogen pro-drugs, on 17beta-estradiol serum kinetics and bone mass in rats

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12 December 2020

Samarium 153Sm lexidronam

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12 December 2020

Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonic prodrug based on the Osteotropic Drug Delivery System (ODDS).

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12 December 2020

Tissue distribution and pharmacological potential of SM-16896, a novel oestrogen-bisphosphonate hybrid compound

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12 December 2020

Bone affinity of a bisphosphonate-conjugated protein in vivo

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12 December 2020

Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats

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12 December 2020

Targeting systemically administered proteins to bone by bisphosphonate conjugation

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12 December 2020

Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis

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12 December 2020

The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration

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12 December 2020

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I.v. effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats

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12 December 2020

Cisplatin-linked phosphonates in the treatment of the transplantable osteosarcoma in vitro and in vivo

1 reference

12 December 2020

Physicochemical characterization of bisphosphonic carboxyfluorescein for osteotropic drug delivery

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12 December 2020

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. V. Biological disposition and targeting characteristics of osteotropic estradiol

1 reference

12 December 2020

Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?

1 reference

12 December 2020

Relationship between physicochemical and osteotropic properties of bisphosphonic derivatives: rational design for osteotropic drug delivery system (ODDS).

1 reference

12 December 2020

Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I: synthesis and in vivo characterization of osteotropic carboxyfluorescein

1 reference

12 December 2020

Reduced morbidity from skeletal metastases in breast cancer patients during long-term bisphosphonate (APD) treatment

1 reference

12 December 2020

Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals

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12 December 2020

Effects of Clodronate and Pamidronate on Splenic and Hepatic Phagocytic Cells of Mice

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12 December 2020

10.2165/00003088-200342150-00002

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

1001274301

0 references

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