(Q35607719)

9 August 2017

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title

Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors (English)

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9 August 2017

main subject

transmembrane protein

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author name string

Knut Kotarsky

1

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9 August 2017

Niclas E Nilsson

2

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9 August 2017

Björn Olde

3

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9 August 2017

Christer Owman

4

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9 August 2017

publication date

1 December 2003

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Basic and Clinical Pharmacology and Toxicology

9 August 2017

published in

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9 August 2017

volume

93

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9 August 2017

issue

6

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9 August 2017

page(s)

249-258

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Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid

9 August 2017

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Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

21 January 2018

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Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1).

21 January 2018

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A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation

21 January 2018

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Neurobiology of the Caenorhabditis elegans genome.

21 January 2018

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

21 January 2018

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Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue

21 January 2018

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Induction of NFAT-mediated transcription by Gq-coupled receptors in lymphoid and non-lymphoid cells

21 January 2018

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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

21 January 2018

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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

21 January 2018

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A G protein-coupled receptor for UDP-glucose

21 January 2018

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Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin

21 January 2018

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Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors

21 January 2018

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Orphan receptors, novel neuropeptides and reverse pharmaceutical research

21 January 2018

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Membrane-permeable luciferin esters for assay of firefly luciferase in live intact cells

21 January 2018

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Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3.

21 January 2018

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Cloning and characterization of murine neuromedin U receptors.

21 January 2018

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Induction of erythroid differentiation by altered Galpha16 activity as detected by a reporter gene assay in MB-02 cells

21 January 2018

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Imaging of light emission from the expression of luciferases in living cells and organisms: a review

21 January 2018

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Characterization of the human cysteinyl leukotriene 2 receptor

21 January 2018

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Reporter-gene systems for the study of G-protein-coupled receptors.

21 January 2018

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Identification and functional characterization of a novel subtype of neuromedin U receptor

21 January 2018

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Orphan G-protein-coupled receptors and natural ligand discovery

21 January 2018

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Identification of receptors for neuromedin U and its role in feeding

21 January 2018

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Orphan G protein-coupled receptors and beyond

21 January 2018

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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

21 January 2018

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Cellular platforms for HTS: three case studies

21 January 2018

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A G protein-coupled receptor responsive to bile acids

21 January 2018

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Detection of beta-lactamase reporter gene expression by flow cytometry

21 January 2018

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Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3).

21 January 2018

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The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54

21 January 2018

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Optimized reporter gene assays based on a synthetic multifunctional promoter and a secreted luciferase

21 January 2018

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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

21 January 2018

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A chimeric reporter gene allowing for clone selection and high-throughput screening of reporter cell lines expressing G-protein-coupled receptors

21 January 2018

1 reference

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Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

21 January 2018

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The superfamily of heptahelical receptors

21 January 2018

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A highly sensitive quantitative cytosensor technique for the identification of receptor ligands in tissue extracts

21 January 2018

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Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2.

21 January 2018

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Improved assay sensitivity of an engineered secreted Renilla luciferase

21 January 2018

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Secretion of functional Renilla reniformis luciferase by mammalian cells

21 January 2018

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Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

21 January 2018

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A cell-based assay system for monitoring NF-kappaB activity in human HaCat transfectant cells

21 January 2018

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Circularly permuted green fluorescent proteins engineered to sense Ca2+.

21 January 2018

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Reporter gene technology: the future looks bright

21 January 2018

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Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63

21 January 2018

1 reference

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Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Primary structure of the Aequorea victoria green-fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Identification of a novel neuromedin U receptor subtype expressed in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Functional Assays for Identifying Ligands at Orphan G Protein-Coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Photoprotein aequorin: use as a reporter enzyme in studying gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Continuous measurement of targeted promoter activity by a secreted bioluminescence reporter, Vargula hilgendorfii luciferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Vargula hilgendorfii luciferase: a secreted reporter enzyme for monitoring gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

The G protein-coupled receptor repertoires of human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Recombinant Gaussia luciferase. Overexpression, purification, and analytical application of a bioluminescent reporter for DNA hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Measurement of responses from Gi-, Gs-, or Gq-coupled receptors by a multiple response element/cAMP response element-directed reporter assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Intracellular detection assays for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Green fluorescent protein (GFP): applications in cell-based assays for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

Molecular cloning and deletion of the gene encoding aspergillopepsin A from Aspergillus awamori

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.2003.PTO930601.X

10.1111/J.1600-0773.2003.PTO930601.X

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference