(Q35612950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

0 references

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Yi-Hung Ou

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

John B. MacMillan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Malia B Potts

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Elizabeth A McMillan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Tracy I Rosales

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Jason E Toombs

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Rolf A Brekken

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Mark D Minden

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Michael A White

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

publication date

13 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

401-408

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio.1797

5 March 2020

exact match

0 references

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer

12 July 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

12 July 2018

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The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

12 July 2018

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

12 July 2018

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Didemnins, tamandarins and related natural products.

12 July 2018

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Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

12 July 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

12 July 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

12 July 2018

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The cancerous translation apparatus

12 July 2018

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S6 kinase 2 promotes breast cancer cell survival via Akt.

12 July 2018

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Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation

12 July 2018

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Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts.

12 July 2018

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Lung cancer cell lines as tools for biomedical discovery and research

12 July 2018

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The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling

12 July 2018

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CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis

12 July 2018

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12 July 2018

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microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma

12 July 2018

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12 July 2018

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Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

12 July 2018

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Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison

12 July 2018

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12 July 2018

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Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition

12 July 2018

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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

12 July 2018

1 reference

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Natural products as probes of cell biology: 20 years of didemnin research

12 July 2018

1 reference

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Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice

12 July 2018

1 reference

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12 July 2018

1 reference

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A new simple enzyme assay for pre- and postnatal diagnosis of infantile neuronal ceroid lipofuscinosis (INCL) and its variants

12 July 2018

1 reference

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Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride

12 July 2018

1 reference

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Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

12 July 2018

1 reference

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Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

12 July 2018

1 reference

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

12 July 2018

1 reference

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Defined chromosomal assignment of CLN5 demonstrates that at least four genetic loci are involved in the pathogenesis of human ceroid lipofuscinoses

12 July 2018

1 reference

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Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433765

Novel marine-derived anti-cancer agents

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1797

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1797

Mechanism of protein synthesis inhibition by didemnin B in vitro

21 January 2018

1 reference

12 December 2020

Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described

1 reference

12 December 2020

Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate

1 reference

12 December 2020

GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha

1 reference

12 December 2020

Regularization and variable selection via the elastic net

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1797

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1797

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25867045%20AND%20SRC:MED&resulttype=core&format=json