(Q35617007)

English

A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion

scientific article published on November 1996

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Pseudomonas aeruginosa

0 references

author name string

J K Gustin

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

E Kessler

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

D E Ohman

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

1 November 1996

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Bacteriology

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

178

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

6608-6617

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Pseudomonas aeruginosa lasA gene: determination of the transcription start point and analysis of the promoter/regulatory region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Pseudomonas aeruginosa lasB1 mutants produce an elastase, substituted at active-site His-223, that is defective in activity, processing, and secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Bacterial extracellular zinc-containing metalloproteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

The complete general secretory pathway in gram-negative bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Secretion and membrane localization of proteins in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Genetic mapping of chromosomal determinants for the production of the exopolysaccharide alginate in a Pseudomonas aeruginosa cystic fibrosis isolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Cloning and expression in Pseudomonas aeruginosa of a gene involved in the production of alginate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Synthesis, processing, and transport of Pseudomonas aeruginosa elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Partial purification and characterization of an inactive precursor of Pseudomonas aeruginosa elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Cloning and transcriptional regulation of the elastase lasA gene in mucoid and nonmucoid Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Activation of an elastase precursor by the lasA gene product of Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Secretion, processing and activation of bacterial extracellular proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Molecular cloning and nucleotide sequence of the beta-lytic protease gene from Achromobacter lyticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Revised nucleotide sequence of the lasA gene from Pseudomonas aeruginosa PAO1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Purification and characterization of an active fragment of the LasA protein from Pseudomonas aeruginosa: enhancement of elastase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Physical mapping of virulence-associated genes in Pseudomonas aeruginosa by transverse alternating-field electrophoresis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Substitution of active-site His-223 in Pseudomonas aeruginosa elastase and expression of the mutated lasB alleles in Escherichia coli show evidence for autoproteolytic processing of proelastase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Efficient production and processing of elastase and LasA by Pseudomonas aeruginosa require zinc and calcium ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

Identification of cleavage sites involved in proteolytic processing of Pseudomonas aeruginosa preproelastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

12 July 2018

The elastase propeptide functions as an intramolecular chaperone required for elastase activity and secretion in Pseudomonas aeruginosa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

25 September 2018

Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=178548

25 September 2018

Pseudomonas aeruginosaLasB mutant constructed by insertional mutagenesis reveais elastolytic activity due to alkaline proteinase and the LasA fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8932318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further studies on Pseudomonas aeruginosa LasA: analysis of specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8932318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The propeptide of Pseudomonas aeruginosa elastase acts an elastase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8932318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-lytic endopeptidases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8932318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of LasD: a second staphylolytic proteinase produced by Pseudomonas aeruginosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/8932318

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JB.178.22.6608-6617.1996

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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