(Q35620042)

9 August 2017

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title

Controlling Abl: auto-inhibition and co-inhibition? (English)

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9 August 2017

Jean Y J Wang

1

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9 August 2017

1 January 2004

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9 August 2017

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9 August 2017

6

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9 August 2017

3-7

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9 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ncb0104-3

9 August 2017

0 references

cites work

Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

1 reference

A myogenic differentiation checkpoint activated by genotoxic stress

21 January 2018

1 reference

Regulation of cell death by the Abl tyrosine kinase

21 January 2018

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

Intrasteric regulation of protein kinases and phosphatases

21 January 2018

1 reference

The protein tyrosine kinase family of the human genome

21 January 2018

1 reference

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

21 January 2018

1 reference

Structure, mechanism and regulation of peroxiredoxins

21 January 2018

1 reference

Inhibition of c-Abl tyrosine kinase activity by filamentous actin

21 January 2018

1 reference

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

21 January 2018

1 reference

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

21 January 2018

1 reference

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

21 January 2018

1 reference

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation

21 January 2018

1 reference

BRCA1 interacts with components of the histone deacetylase complex

21 January 2018

1 reference

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

21 January 2018

1 reference

Caspase-dependent cleavage of c-Abl contributes to apoptosis

21 January 2018

1 reference

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

21 January 2018

1 reference

Structural basis for the autoinhibition of c-Abl tyrosine kinase

21 January 2018

1 reference

7 January 2021

The conformational plasticity of protein kinases

1 reference

7 January 2021

Variation on an Src-like theme

1 reference

7 January 2021

An intramolecular SH3-domain interaction regulates c-Abl activity

1 reference

7 January 2021

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

7 January 2021

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

1 reference

7 January 2021

A myristoyl/phosphotyrosine switch regulates c-Abl

1 reference

7 January 2021

Autoinhibition of c-Abl

1 reference

7 January 2021

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1

1 reference

7 January 2021

Abl tyrosine kinase in signal transduction and cell-cycle regulation

1 reference

7 January 2021

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1 reference

7 January 2021

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1 reference

7 January 2021

Autoinhibition of Bcr-Abl through its SH3 domain

1 reference

7 January 2021

Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation

1 reference

7 January 2021

Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB0104-3

1 reference

9 August 2017

1 reference

PubMed ID

14704671