(Q35640730)

9 August 2017

1 reference

title

"Cocktail" approaches and strategies in drug development: valuable tool or flawed science? (English)

1 reference

9 August 2017

Honghui Zhou

1

1 reference

PubMed ID

14747420

9 August 2017

Zeen Tong

series ordinal

2

1 reference

PubMed ID

14747420

9 August 2017

James F McLeod

series ordinal

3

1 reference

9 August 2017

1 February 2004

1 reference

The Journal of Clinical Pharmacology

9 August 2017

1 reference

9 August 2017

44

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9 August 2017

120-134

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9 August 2017

2

1 reference

Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach

9 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Assessment of cytochrome P450 activity by a five-drug cocktail approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Assessment of the quality and quantity of drug-drug interaction studies in recent NDA submissions: study design and data analysis issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Clinical-pharmacological strategies to assess drug interaction potential during drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Concepts in causality: chemically induced human urinary bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Simultaneous administration of a cocktail of markers to measure renal drug elimination pathways: absence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and pindolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

In vivo pharmacokinetic screening in cassette dosing experiments; the use of on-line Pprospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a "cocktail" study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Assessment of liver metabolic function. Clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Dapsone N-acetylation, metoprolol alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonesian population: a cocktail and extended phenotyping assessment trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Different effects of St John's wort on the pharmacokinetics of simvastatin and pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

The interaction of diltiazem with simvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: A cocktail study with dextromethorphan and chloroguanide alone and in combination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Interindividual variations in drug disposition. Clinical implications and methods of investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Cocktail strategy: complications and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Another perspective on the cocktail strategy: "two glasses of wine or a six pack"

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Influence of renal failure on cytochrome P 450 activity in hypertensive patients using a "cocktail" of antipyrine and nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Epoxidation of acrylonitrile by rat and human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

In vivo effects of interleukin-10 on human cytochrome P450 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Comparison of hepatic drug-oxidizing activity after simultaneous administration of two probe drugs, caffeine and trimethadione, to human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Intraindividual variability in theophylline pharmacokinetics in subjects with mild/moderate asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003261333

21 January 2018

Identifiers

DOI

10.1177/0091270003261333

1 reference

9 August 2017

1 reference

PubMed ID

14747420