(Q35644521)

English

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

scientific article published on 21 April 2015

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

haploinsufficiency

0 references

metabolic disease

1 reference

based on heuristic

1 reference

based on heuristic

corrigendum / erratum

Corrigendum to "Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy" [Mol Metab 4 (6) (2015) 493-506].

1 reference

10.1016/J.MOLMET.2015.06.005

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1016/J.MOLMET.2015.06.005

author name string

Lalage A Katunga

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Preeti Gudimella

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jimmy T Efird

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Scott Abernathy

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Taylor A Mattox

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Cherese Beatty

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Timothy M Darden

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Kathleen A Thayne

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Hazaim Alwair

9

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Alan P Kypson

10

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jitka A Virag

11

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Ethan J Anderson

12

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

publication date

21 April 2015

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Molecular Metabolism

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

493-506

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose.

1 reference

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Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damage

1 reference

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27 July 2018

Molecular mechanisms of aldehyde toxicity: a chemical perspective

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Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013

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Keshan disease, selenium deficiency, and the selenoproteome

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Monoamine oxidase is a major determinant of redox balance in human atrial myocardium and is associated with postoperative atrial fibrillation.

1 reference

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Does reversible cysteine oxidation link the Western diet to cardiac dysfunction?

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Cellular signalling of the receptor for advanced glycation end products (RAGE).

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Protein carbonylation, mitochondrial dysfunction, and insulin resistance

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Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase

1 reference

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4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart

1 reference

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High dietary fat selectively increases catalase expression within cardiac mitochondria

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Protein carbonylation and adipocyte mitochondrial function.

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27 July 2018

Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells

1 reference

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The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice.

1 reference

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27 July 2018

Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.

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Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver

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D-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation.

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27 July 2018

Lipid metabolism and body composition in Gclm(-/-) mice

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27 July 2018

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

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4-Hydroperoxy-2-nonenal is not just an intermediate but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products

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Specific antioxidant selenoproteins are induced in the heart during hypertrophy

1 reference

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27 July 2018

Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

27 July 2018

Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

27 July 2018

Pre-clinical diabetic cardiomyopathy: prevalence, screening, and outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

27 July 2018

Protein adducts of aldehydic lipid peroxidation products identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometry

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27 July 2018

Metabolic adaptation follows contractile dysfunction in the heart of obese Zucker rats fed a high-fat "Western" diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

27 July 2018

Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

27 July 2018

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

1 reference

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Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation

1 reference

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27 July 2018

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

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27 July 2018

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

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27 July 2018

Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex.

1 reference

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27 July 2018

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

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Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

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27 July 2018

Role of cardiolipin alterations in mitochondrial dysfunction and disease

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

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Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

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Intracellular metabolism of 4-hydroxynonenal

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25 September 2018

DNA adducts with lipid peroxidation products

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Intracardiac lipid accumulation, lipoatrophy of muscle cells and expansion of myocardial infarction in type 2 diabetic patients.

1 reference

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25 September 2018

Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats

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Cardiac cell death in early diabetes and its modulation by dietary fatty acids

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Effects of gpx4 haploid insufficiency on GPx4 activity, selenium concentration, and paraquat-induced protein oxidation in murine tissues

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25 September 2018

Biological significance of lipid hydroperoxide and its reducing enzyme, phospholipid hydroperoxide glutathione peroxidase, in mammalian cells

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Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

1 reference

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Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

25 September 2018

Role of lipids in chemical modification of proteins and development of complications in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

25 September 2018

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

25 September 2018

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

25 September 2018

A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

25 September 2018

SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443294

15 November 2018

RAGE: a single receptor fits multiple ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term efficacy of edaravone in patients with acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipid hydroperoxide glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26042203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLMET.2015.04.001

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

0 references

Sitelinks

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