(Q35659046)

English

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage

scientific article published on 9 December 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22150444%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22150444%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

status epilepticus

1 reference

based on heuristic

inferred from title

organophosphate

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Tawfeeq Shekh-Ahmad

5

1 reference

Europe PubMed Central

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18 January 2020

author name string

H Steve White

1

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18 January 2020

Anitha B Alex

2

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18 January 2020

Amanda Pollock

3

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18 January 2020

Naama Hen

4

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18 January 2020

Karen S Wilcox

6

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18 January 2020

John H McDonough

7

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18 January 2020

James P Stables

8

1 reference

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18 January 2020

Dan Kaufmann

9

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18 January 2020

Boris Yagen

10

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18 January 2020

Meir Bialer

11

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18 January 2020

publication date

9 December 2011

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18 January 2020

1 reference

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18 January 2020

53

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18 January 2020

1

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18 January 2020

134-146

1 reference

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18 January 2020

CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Key factors in the discovery and development of new antiepileptic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Emerging concepts in the pathogenesis of epilepsy and epileptogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Discovery of antiepileptic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Molecular targets versus models for new antiepileptic drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Cognitive outcomes and predictive factors in epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Epidemiology and evidence for morbidity of nonconvulsive status epilepticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Anticonvulsants for soman-induced seizure activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Incidence of status epilepticus in Rochester, Minnesota, 1965-1984.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Seizure circuits in the hippocampus and associated structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Modification of seizure activity by electrical stimulation. II. Motor seizure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Screening and characterization of antiepileptic drugs with rapidly recurring hippocampal seizures in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Anticonvulsants for poisoning by the organophosphorus compound soman: Pharmacological mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

27 July 2018

Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Comparison of valproate and phenobarbital treatment after status epilepticus in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Effect of topiramate following recurrent and prolonged seizures during early development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

The aspects and mechanisms of cognitive alterations in epilepsy: the role of antiepileptic medications.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Pharmacological modulation of soman-induced seizures.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Valproate therapy for prevention of posttraumatic seizures: a randomized trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Valproic acid reduces spatial working memory and cell proliferation in the hippocampus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2011.03338.X

21 January 2018

Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Organotypic brain slice cultures: an efficient and reliable method for neurotoxicological screening and mechanistic studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Comparative evaluation of benzodiazepines for control of soman-induced seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Neurochemical mechanisms in soman-induced seizures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Long-term behavioral deficits following pilocarpine seizures in immature rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

Seizure-related opening of the blood-brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253224

25 September 2018

The search for new drugs against epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seizure recurrence after a 1st unprovoked seizure: an extended follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and use of a new electroshock seizure apparatus, and analysis of factors altering seizure threshold and pattern

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of soman-induced neuropathology with an anticonvulsant regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statisical logic in the monitoring of reactions to therapeutic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A note on a simple apparatus for detecting neurological deficit in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22150444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1528-1167.2011.03338.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22150444%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22150444%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22150444%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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