(Q35663346)

English

Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

scientific article published on 26 February 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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author name string

Perdita L Pugh

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Martin P Vidgeon-Hart

2

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Europe PubMed Central

PubMed publication ID

9 August 2017

Tracey Ashmeade

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Ainsley A Culbert

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Zoe Seymour

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Marion J Perren

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Flora Joyce

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Simon T Bate

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Anna Babin

9

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

David J Virley

10

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jill C Richardson

11

1 reference

Europe PubMed Central

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9 August 2017

Neil Upton

12

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Europe PubMed Central

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9 August 2017

David Sunter

13

1 reference

Europe PubMed Central

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9 August 2017

language of work or name

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publication date

26 February 2007

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Europe PubMed Central

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9 August 2017

Journal of Neuroinflammation

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Europe PubMed Central

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9 August 2017

4

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Europe PubMed Central

PubMed publication ID

9 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.

1 reference

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Neuronal signalling of fear memory

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Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production

1 reference

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Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

1 reference

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A distinct role for norepinephrine in memory retrieval

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Intrinsic regulation of brain inflammatory responses.

1 reference

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Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.

1 reference

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Protective effects of the alpha 2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat.

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Alzheimer's disease is a synaptic failure

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Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.

1 reference

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12 July 2018

Catecholamines inhibit microglial nitric oxide production

1 reference

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12 July 2018

Neuroinflammation and Alzheimer disease: clinical and therapeutic implications.

1 reference

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12 July 2018

Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1 alpha via a beta adrenoceptor mediated mechanism

1 reference

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Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

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12 July 2018

Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810243

12 July 2018

Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810243

12 July 2018

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810243

25 September 2018

Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.

1 reference

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Norepinephrine protects cortical neurons against microglial-induced cell death.

1 reference

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25 September 2018

The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration caused by low-level oxidative stress.

1 reference

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25 September 2018

Noradrenaline and dopamine elevations in the rat prefrontal cortex in spatial working memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810243

25 September 2018

Protective effect of the alpha2-adrenoceptor antagonist, dexefaroxan, against spatial memory deficit induced by cortical devascularization in the adult rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810243

25 September 2018

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

1 reference

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Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors

1 reference

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Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents

1 reference

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Genetic evidence for noradrenergic control of long-term memory consolidation

1 reference

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25 September 2018

Noradrenaline provides long-term protection to dopaminergic neurons by reducing oxidative stress.

1 reference

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Upregulation of death pathway molecules in rat cerebellar granule neurons undergoing apoptosis.

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25 September 2018

Alzheimer disease and neuroinflammation.

1 reference

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25 September 2018

A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: a microdialysis study in vivo.

1 reference

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The spectrum of behavioral changes in Alzheimer's disease.

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Differential effect of selective block of alpha 2-adrenoreceptors on plasma levels of tumour necrosis factor-alpha, interleukin-6 and corticosterone induced by bacterial lipopolysaccharide in mice.

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Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17324270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17324270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-4-8

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Europe PubMed Central

PubMed publication ID

9 August 2017

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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