(Q35666147)

9 August 2017

1 reference

title

Early prediction of drug metabolism and toxicity: systems biology approach and modeling (English)

1 reference

9 August 2017

Andrej Bugrim

1

1 reference

PubMed ID

14960390

9 August 2017

Tatiana Nikolskaya

series ordinal

2

1 reference

PubMed ID

14960390

9 August 2017

Yuri Nikolsky

series ordinal

3

1 reference

9 August 2017

1 February 2004

1 reference

9 August 2017

1 reference

9 August 2017

9

1 reference

9 August 2017

3

1 reference

9 August 2017

127-135

1 reference

META. 2. A dictionary model of mammalian xenobiotic metabolism.

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

META. 1. A program for the evaluation of metabolic transformation of chemicals.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Using new reasoning technology in chemical information systems.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

META. 3. A genetic algorithm for metabolic transform priorities optimization.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Modeling of human cytochrome p450-mediated drug metabolism using unsupervised machine learning approach

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Pharmacophore modeling of cytochromes P450.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

An improved and updated version of the compact procedure for the evaluation of P450-mediated chemical activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Modeling of active transport systems

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

A pharmacophore for human pregnane X receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Effects of L-proline on phase I and phase II xenobiotic biotransformation capacities of rat and human hepatocytes in long-term collagen gel cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Effects of propofol on functional activities of hepatic and extrahepatic conjugation enzyme systems.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Identification of toxicologically predictive gene sets using cDNA microarrays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Drug research: myths, hype and reality

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Proteomics: quantitative and physical mapping of cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Functional organization of the yeast proteome by systematic analysis of protein complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The effects of peroxisome proliferators on protein abundances in mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Changes in the liver protein pattern of female Wistar rats treated with the hypoglycemic agent SDZ PGU 693.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Key challenges for toxicologists in the 21st century

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Characterization of diet-dependent metabolic serotypes: analytical and biological variability issues in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Metabonomics: a platform for studying drug toxicity and gene function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The KEGG databases at GenomeNet

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

MPW: the Metabolic Pathways Database

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Microbiology. The thin line between gut commensal and pathogen

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The digital code of DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

BRENDA, enzyme data and metabolic information

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The metabolic pathway collection from EMP: the enzymes and metabolic pathways database

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

1 reference

7 January 2021

Metabolic modeling of microbial strains in silico.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Functional analysis of gapped microbial genomes: amino acid metabolism of Thiobacillus ferrooxidans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Modular organization of cellular networks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

The identification of functional modules from the genomic association of genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Protein complexes and functional modules in molecular networks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902971-4

7 January 2021

10.1016/S1359-6446(03)02971-4

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14960390