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SAMHD1 specifically restricts retroviruses through its RNase activity.
scientific article published on 2 June 2015
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Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
title
SAMHD1 specifically restricts retroviruses through its RNase activity
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
author
Jongsu Choi
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
author name string
Jeongmin Ryoo
series ordinal
2
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Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
Changhoon Oh
series ordinal
3
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Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
Sungyeon Hwang
series ordinal
4
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4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
Kwangseog Ahn
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
publication date
2 June 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
published in
Retrovirology
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
volume
12
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Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
page(s)
46
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stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
cites work
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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PubMed Central
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Mechanism of allosteric activation of SAMHD1 by dGTP
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Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.
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PubMed Central
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12 July 2018
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells
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Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.
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The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
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PubMed Central
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Restriction of diverse retroviruses by SAMHD1.
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12 July 2018
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection
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PubMed Central
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12 July 2018
Single-stranded nucleic acids promote SAMHD1 complex formation
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Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.
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Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
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12 July 2018
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
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12 July 2018
The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus
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12 July 2018
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
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PubMed Central
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12 July 2018
Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
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PubMed Central
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12 July 2018
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations
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PubMed Central
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12 July 2018
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
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12 July 2018
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.
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PubMed Central
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12 July 2018
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection
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PubMed Central
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12 July 2018
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450836
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12 July 2018
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450836
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12 July 2018
SAMHD1: a new insight into HIV-1 restriction in myeloid cells
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PubMed Central
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12 July 2018
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
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12 July 2018
Cerebral vasculopathy is a common feature in Aicardi-Goutieres syndrome associated with SAMHD1 mutations
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PubMed Central
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12 July 2018
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
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PubMed Central
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12 July 2018
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
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12 July 2018
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
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Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity
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12 July 2018
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response
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12 July 2018
Ribonuclease H: the enzymes in eukaryotes
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12 July 2018
The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies
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Transduction of nondividing human macrophages with gammaretrovirus-derived vectors
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Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors
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12 July 2018
Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins
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Feline immunodeficiency virus OrfA is distinct from other lentivirus transactivators
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The S2 gene of equine infectious anemia virus is dispensable for viral replication in vitro
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Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase.
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Analysis of multiple mRNAs from pathogenic equine infectious anemia virus (EIAV) in an acutely infected horse reveals a novel protein, Ttm, derived from the carboxy terminus of the EIAV transmembrane protein.
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12 July 2018
Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase
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Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.
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25 September 2018
Separation of copurifying GroEL from glutathione-S-transferase fusion proteins
1 reference
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reference URL
https://pubmed.ncbi.nlm.nih.gov/26032178
retrieved
12 December 2020
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Identifiers
DOI
10.1186/S12977-015-0174-4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
Dimensions Publication ID
1023401144
0 references
PMC publication ID
4450836
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PubMed publication ID
26032178
1 reference
stated in
Europe PubMed Central
PMC publication ID
4450836
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26032178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
ResearchGate publication ID
277558790
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