(Q35682870)

9 August 2017

title

A mechanistic modeling framework for predicting metabolic interactions in complex mixtures (English)

1 reference

9 August 2017

Shu Cheng

1

1 reference

9 August 2017

Frederic Y Bois

series ordinal

2

1 reference

9 August 2017

publication date

11 August 2011

1 reference

Environmental Health Perspectives

9 August 2017

published in

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9 August 2017

volume

119

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9 August 2017

issue

12

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9 August 2017

page(s)

1712-1718

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PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

9 August 2017

cites work

1 reference

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12 July 2018

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Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction

12 July 2018

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Human benzene metabolism following occupational and environmental exposures

12 July 2018

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Physiologically based modelling and prediction of drug interactions

12 July 2018

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Evidence that humans metabolize benzene via two pathways

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Statistical issues in toxicokinetic modeling: a bayesian perspective

12 July 2018

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Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

12 July 2018

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Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

12 July 2018

1 reference

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Population toxicokinetics of benzene

12 July 2018

1 reference

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The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives

12 July 2018

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The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures

12 July 2018

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Deviations from Michaelis-Menten kinetics. The possibility of complicated curves for simple kinetic schemes and the computer fitting of experimental data for acetylcholinesterase, acid phosphatase, adenosine deaminase, arylsulphatase, benzylamine ox

12 July 2018

1 reference

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An analysis of exposure rate effects for benzene using a physiologically based pharmacokinetic model

12 July 2018

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Dose any enzyme follow the Michaelis-Menten equation?

12 July 2018

1 reference

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Drug elimination interactions: analysis using a mathematical model

12 July 2018

1 reference

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Modeling the formation and reactions of benzene metabolites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261979

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25 September 2018

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Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes

25 September 2018

1 reference

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25 September 2018

1 reference

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Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261979

A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261979

Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261979

Pharmacokinetics of benzene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261979

Induction of hepatic CYP2B is a more sensitive indicator of exposure to aroclor 1260 than CYP1A in male rats

25 September 2018

1 reference

12 December 2020

Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures

1 reference

12 December 2020

Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes

1 reference

12 December 2020

Comparison of the influence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat

1 reference

12 December 2020

Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

1 reference

12 December 2020

Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons

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12 December 2020

Identifiers

DOI

10.1289/EHP.1103510

1 reference

9 August 2017

1 reference

9 August 2017

1 reference