(Q35683221)

9 August 2017

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title

Benefit-risk assessment of long-acting beta2-agonists in asthma (English)

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9 August 2017

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Catherine M Jackson

1

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9 August 2017

Brian Lipworth

series ordinal

2

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9 August 2017

publication date

1 January 2004

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9 August 2017

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9 August 2017

volume

27

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9 August 2017

issue

4

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9 August 2017

page(s)

243-270

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https://scigraph.springernature.com/pub.10.2165/00002018-200427040-00003

9 August 2017

exact match

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cites work

Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting beta2-agonist therapy

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Beta-agonist intrinsic efficacy: measurement and clinical significance

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The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol

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Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone

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Rapid Onset of Tolerance to the Bronchoprotective Effect of Salmeterol

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A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma.

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Effects of once-daily formoterol and budesonide given alone or in combination on surrogate inflammatory markers in asthmatic adults

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Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids

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Low-dose inhaled corticosteroids and the prevention of death from asthma

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Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma

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12 December 2020

Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism

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12 December 2020

The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma

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12 December 2020

Acute systemic effects of inhaled salbutamol in asthmatic subjects expressing common homozygous beta2-adrenoceptor haplotypes at positions 16 and 27

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12 December 2020

In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids

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12 December 2020

Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics

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12 December 2020

Systemic effects of formoterol and salmeterol: a dose-response comparison in healthy subjects

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12 December 2020

Second-line controller therapy for persistent asthma uncontrolled on inhaled corticosteroids: the step 3 dilemma

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12 December 2020

Salmeterol does not compromise the bronchodilator response to albuterol during acute episodes of asthma

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12 December 2020

Effects of treatment with formoterol on bronchoprotection against methacholine

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12 December 2020

Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease

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12 December 2020

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing

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12 December 2020

Regular inhaled salbutamol and asthma control: the TRUST randomised trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework

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12 December 2020

Evaluation of salmeterol or montelukast as second-line therapy for asthma not controlled with inhaled corticosteroids

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Bronchodilator subsensitivity after chronic dosing with eformoterol in patients with asthma

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12 December 2020

Effects of formoterol on histamine induced plasma exudation in induced sputum from normal subjects

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12 December 2020

Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients.

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12 December 2020

Inhaled salmeterol and fluticasone: a study comparing monotherapy and combination therapy in asthma

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12 December 2020

Salmeterol/fluticasone propionate (50/500 microg) in combination in a Diskus inhaler (Seretide) is effective and safe in the treatment of steroid-dependent asthma

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12 December 2020

beta-adrenergic agonist resistance in normal human airways

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12 December 2020

Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist

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Effect of short- and long-acting beta 2-adrenoceptor agonists on pulmonary beta 2-adrenoceptor expression in human lung

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12 December 2020

Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients

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12 December 2020

Concomitant administration of low-dose prednisolone protects against in vivo beta2-adrenoceptor subsensitivity induced by regular formoterol

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12 December 2020

The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization

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12 December 2020

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.

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12 December 2020

Tolerance to the protective effect of salmeterol on allergen challenge

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12 December 2020

Lack of subsensitivity to albuterol after treatment with salmeterol in patients with asthma

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12 December 2020

Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline

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12 December 2020

Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen

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12 December 2020

Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids.

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12 December 2020

Concomitant inhaled corticosteroid resensitises cardiac beta2-adrenoceptors in the presence of long-acting beta2-agonist therapy

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12 December 2020

Short-term cardiovascular effects of salmeterol

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12 December 2020

Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma

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12 December 2020

Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma

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12 December 2020

Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness

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12 December 2020

Additive anti-inflammatory effect of formoterol and budesonide on human lung fibroblasts

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12 December 2020

Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells

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12 December 2020

Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers

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12 December 2020

The long‐acting β2‐agonist salmeterol xinafoate: effects on airway inflammation in asthma

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12 December 2020

Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta(2)-adrenoceptor polymorphism

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12 December 2020

Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma

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12 December 2020

Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial

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12 December 2020

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12 December 2020

A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic subjects receiving regular salmeterol or formoterol

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12 December 2020

Regular inhaled salbutamol and airway responsiveness to allergen

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12 December 2020

Reversal of human lymphocyte beta-adrenoceptor desensitization by glucocorticoids

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12 December 2020

Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma.

1 reference

12 December 2020

Revisiting interactions between hypoxaemia and beta2 agonists in asthma

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12 December 2020

Physiological regulation at the level of mRNA: analysis of steady-state levels of specific mRNAs by DNA-excess solution hybridization

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12 December 2020

An antiinflammatory effect of salmeterol, a long-acting beta(2) agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma

1 reference

12 December 2020

Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling

1 reference

12 December 2020

Regular vs as-needed inhaled salbutamol in asthma control

1 reference

12 December 2020

Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients

1 reference

12 December 2020

An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist

1 reference

12 December 2020

Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting beta2 agonists

1 reference

12 December 2020

Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma

1 reference

12 December 2020

Lack of subsensitivity to albuterol after treatment with salmeterol in patients with asthma

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12 December 2020

Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial

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12 December 2020

Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group

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12 December 2020

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

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12 December 2020

Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment

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12 December 2020

Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol

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12 December 2020

Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids

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12 December 2020

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

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12 December 2020

Regular inhaled beta-agonist treatment in bronchial asthma.

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12 December 2020

The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma

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12 December 2020

Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial

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12 December 2020

Salmeterol: a study by prescription-event monitoring in a UK cohort of 15,407 patients

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12 December 2020

The effect of salmeterol on markers of airway inflammation following segmental allergen challenge

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12 December 2020

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

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12 December 2020

Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma

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12 December 2020

A comparison of salmeterol and formoterol in attenuating airway responses to short-acting β2-agonists

1 reference

12 December 2020

Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrhythmias and hypoxemia

1 reference

12 December 2020

The interaction between salmeterol and beta 2-adrenoceptor agonists with higher efficacy on guinea-pig trachea and human bronchus in vitro

1 reference

12 December 2020

Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Montelukast/Salmeterol Exercise Study Group

1 reference

12 December 2020

Long-term cardiovascular safety of salmeterol powder pharmacotherapy in adolescent and adult patients with chronic persistent asthma: a randomized clinical trial

1 reference

12 December 2020

Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

1 reference

12 December 2020

Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics.

1 reference

12 December 2020

The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

1 reference

12 December 2020

A bolus of inhaled budesonide rapidly reverses airway subsensitivity and beta2-adrenoceptor down-regulation after regular inhaled formoterol.

1 reference

12 December 2020

Long-term circadian effects of salmeterol in asthmatic children treated with inhaled corticosteroids

1 reference

12 December 2020

The use of beta-agonists and the risk of death and near death from asthma

1 reference

12 December 2020

Systemic corticosteriod rapidly reverses bronchodilator subsensitivity induced by formoterol in asthmatic patients

1 reference

12 December 2020

Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol

1 reference

12 December 2020

Addition of salmeterol versus doubling the dose of fluticasone propionate in patients with mild to moderate asthma

1 reference

12 December 2020

Add-on therapy with montelukast or formoterol in patients with the glycine-16 beta2-receptor genotype

1 reference

12 December 2020

Subsensitivity to bronchoprotection against adenosine monophosphate challenge following regular once-daily formoterol

1 reference

12 December 2020

In vivo effect of albuterol on methacholine-contracted bronchi in conjunction with salmeterol and formoterol

1 reference

12 December 2020

Salmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism

1 reference

12 December 2020

Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone

1 reference

12 December 2020

Potential masking effects of salmeterol on airway inflammation in asthma

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12 December 2020

Steroid-sparing effects of fluticasone propionate 100 microg and salmeterol 50 microg administered twice daily in a single product in patients previously controlled with fluticasone propionate 250 microg administered twice daily

1 reference

12 December 2020

A comparison of salmeterol with albuterol in the treatment of mild-to-moderate asthma

1 reference

12 December 2020

Effects of genetic polymorphism on ex vivo and in vivo function of beta2-adrenoceptors in asthmatic patients

1 reference

12 December 2020

Effect of prednisolone and ketotifen on beta 2-adrenoceptors in asthmatic patients receiving beta 2-bronchodilators

1 reference

12 December 2020

Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administration

1 reference

12 December 2020

Effect of long-term salmeterol treatment on exercise-induced asthma

1 reference

12 December 2020

The addition of salmeterol to fluticasone propionate versus increasing the dose of fluticasone propionate in patients with persistent asthma. Salmeterol Study Group

1 reference

12 December 2020

Twelve month comparison of salmeterol and salbutamol as dry powder formulations in asthmatic patients. European Study Group

1 reference

12 December 2020

Effect of long-term treatment with salmeterol on asthma control: a double blind, randomised crossover study

1 reference

12 December 2020

Comparison of combination inhalers vs inhaled corticosteroids alone in moderate persistent asthma.

1 reference

12 December 2020

Combined salmeterol 50 microg and fluticasone propionate 250 microg in the diskus device for the treatment of asthma

1 reference

12 December 2020

Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol

1 reference

12 December 2020

Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial

1 reference

12 December 2020

Agonist-Promoted High Affinity State of the β-Adrenergic Receptor in Human Neutrophils: Modulation by Corticosteroids*

1 reference

12 December 2020

Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast

1 reference

12 December 2020

Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group

1 reference

12 December 2020

Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis

1 reference

12 December 2020

Airway responsiveness after a single dose of salmeterol and during four months of treatment in children with asthma

1 reference

12 December 2020

Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids

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12 December 2020

Salmeterol tachyphylaxis in steroid treated asthmatic subjects

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12 December 2020

Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment.

1 reference

12 December 2020

Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma

1 reference

12 December 2020

Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics

1 reference

12 December 2020

Salmeterol and conventional asthma therapy

1 reference

12 December 2020

Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial

1 reference

12 December 2020

Effect of combining salmeterol and fluticasone on the progression of airway remodeling

1 reference

12 December 2020

Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers

1 reference

12 December 2020

Long- and short-acting beta2 adrenoceptor agonists: interactions in human contracted bronchi

1 reference

12 December 2020

Cardiovascular safety of salmeterol in COPD.

1 reference

12 December 2020

10.2165/00002018-200427040-00003

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

1008046870

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