(Q35705259)

9 August 2017

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title

Strategies for dealing with metabolite elucidation in drug discovery and development (English)

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9 August 2017

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Alaa-Eldin F Nassar

1

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9 August 2017

Rasmy E Talaat

series ordinal

2

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9 August 2017

publication date

1 April 2004

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9 August 2017

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9 August 2017

volume

9

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9 August 2017

issue

7

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9 August 2017

page(s)

317-327

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Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

9 August 2017

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7 January 2021

Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadruple time-of-flight mass spectrometry and in-silico prediction

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7 January 2021

An ABC of Drug-Related Problems

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7 January 2021

Reactive metabolite screen for reducing candidate attrition in drug discovery

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7 January 2021

RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY APCI METHOD FOR DETERMINATION OF NITROGEN CONTAINING COMPOUNDS IN PLASMA*

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7 January 2021

Quantitative analysis of hydrocortisone in human urine using a high-performance liquid chromatographic-tandem mass spectrometric-atmospheric-pressure chemical ionization method

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7 January 2021

Screening for the potential of a drug candidate to cause idiosyncratic drug reactions

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7 January 2021

Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

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7 January 2021

Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.

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Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

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7 January 2021

Accelerated metabolite identification by “Extraction-NMR”

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7 January 2021

Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.

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Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy

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7 January 2021

LC-NMR-MS in drug discovery

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Application of atmospheric pressure ionization time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites.

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7 January 2021

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7 January 2021

Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process

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7 January 2021

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7 January 2021

Hyphenated HPLC-NMR and its applications in drug discovery

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7 January 2021

Liquid chromatographic-tandem mass spectrometric method for the analysis of a neurokinin-1 antagonist and its metabolite using automated solid-phase sample preparation and automated data handling and reporting.

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7 January 2021

Evaluation of an automated liquid-handling system (Tecan Genesis RSP 100) in the Abbott LCx assay for Chlamydia trachomatis

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7 January 2021

Exact mass measurement on an electrospray ionization time-of-flight mass spectrometer: error distribution and selective averaging

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7 January 2021

Computer systems for the prediction of toxicity: an update

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7 January 2021

Structure-based methods for predicting mutagenicity and carcinogenicity: are we there yet?

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7 January 2021

Quantitative structure--activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character

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7 January 2021

Collisional activation with random noise in ion trap mass spectrometry

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7 January 2021

Gas-phase folding and unfolding of cytochrome c cations.

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7 January 2021

High-performance liquid chromatography with amperometric detection applied to the screening of 1,4-dihydropyridines in human plasma

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7 January 2021

NMR-Based amide hydrogen-deuterium exchange measurements for complex membrane proteins: development and critical evaluation

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7 January 2021

Gas phase hydrogen deuterium exchange reactions of a model peptide: FT-ICR and computational analyses of metal induced conformational mutations

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7 January 2021

Hydrogen/deuterium exchange of nucleotides in the gas phase

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7 January 2021

Hydrogen—deuterium exchange in fused-silica capillary columns

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7 January 2021

Gas-phase hydrogen/deuterium exchange of positively charged mononucleotides by use of Fourier-transform ion cyclotron resonance mass spectrometry

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7 January 2021

Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayers.

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7 January 2021

The application of nuclear magnetic resonance spectroscopy to drug metabolism studies

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7 January 2021

Use of a microplate scintillation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism

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7 January 2021

On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development

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7 January 2021

10.1016/S1359-6446(03)03018-6

Identifiers

DOI

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9 August 2017

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