(Q35705259)

9 August 2017

1 reference

title

Strategies for dealing with metabolite elucidation in drug discovery and development (English)

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9 August 2017

1 reference

Alaa-Eldin F Nassar

1

1 reference

PubMed ID

15037231

9 August 2017

Rasmy E Talaat

series ordinal

2

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9 August 2017

1 April 2004

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9 August 2017

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9 August 2017

9

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9 August 2017

317-327

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9 August 2017

7

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Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadruple time-of-flight mass spectrometry and in-silico prediction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

An ABC of Drug-Related Problems

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Reactive metabolite screen for reducing candidate attrition in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

RAPID HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY APCI METHOD FOR DETERMINATION OF NITROGEN CONTAINING COMPOUNDS IN PLASMA*

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Quantitative analysis of hydrocortisone in human urine using a high-performance liquid chromatographic-tandem mass spectrometric-atmospheric-pressure chemical ionization method

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Screening for the potential of a drug candidate to cause idiosyncratic drug reactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Accelerated metabolite identification by “Extraction-NMR”

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

LC-NMR-MS in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Application of atmospheric pressure ionization time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

'Metabolic mapping' of drugs: rapid screening techniques for xenobiotic metabolites with m.s./m.s. techniques

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chrom

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Accelerating the drug optimization process: identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Directly coupled HPLC-NMR and HPLC-MS approaches for the rapid characterisation of drug metabolites in urine: application to the human metabolism of naproxen

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Hyphenated HPLC-NMR and its applications in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Liquid chromatographic-tandem mass spectrometric method for the analysis of a neurokinin-1 antagonist and its metabolite using automated solid-phase sample preparation and automated data handling and reporting.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Evaluation of an automated liquid-handling system (Tecan Genesis RSP 100) in the Abbott LCx assay for Chlamydia trachomatis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Exact mass measurement on an electrospray ionization time-of-flight mass spectrometer: error distribution and selective averaging.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Computer systems for the prediction of toxicity: an update

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Structure-based methods for predicting mutagenicity and carcinogenicity: are we there yet?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Quantitative structure--activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Collisional activation with random noise in ion trap mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Gas-phase folding and unfolding of cytochrome c cations.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

High-performance liquid chromatography with amperometric detection applied to the screening of 1,4-dihydropyridines in human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

NMR-Based amide hydrogen-deuterium exchange measurements for complex membrane proteins: development and critical evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Gas phase hydrogen deuterium exchange reactions of a model peptide: FT-ICR and computational analyses of metal induced conformational mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Hydrogen/deuterium exchange of nucleotides in the gas phase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Hydrogen—deuterium exchange in fused-silica capillary columns

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Gas-phase hydrogen/deuterium exchange of positively charged mononucleotides by use of Fourier-transform ion cyclotron resonance mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayers.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

The application of nuclear magnetic resonance spectroscopy to drug metabolism studies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

Use of a microplate scintillation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903018-6

7 January 2021

10.1016/S1359-6446(03)03018-6

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

15037231