(Q35708128)

9 August 2017

1 reference

title

Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches (English)

1 reference

9 August 2017

1 reference

1 reference

Steve E Humphries

1

1 reference

9 August 2017

Laleh Morgan

series ordinal

2

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9 August 2017

publication date

1 April 2004

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9 August 2017

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9 August 2017

volume

3

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9 August 2017

issue

4

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9 August 2017

page(s)

227-235

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A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoi

9 August 2017

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7 January 2021

Fibrinogen, cigarette smoking, and risk of cardiovascular disease: insights from the Framingham Study

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7 January 2021

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7 January 2021

Risk factors for first-ever stroke in older people in the north East of England: a population-based study

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7 January 2021

Cigarette Smoking and Risk of Stroke in Middle-Aged Women

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7 January 2021

Cigarette smoking. A risk factor for cerebral infarction in young adults

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7 January 2021

How soon after quitting smoking does risk of heart attack decline?

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7 January 2021

Long-Term Outcome after Ischaemic Stroke/Transient Ischaemic Attack

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7 January 2021

Cigarette smoking and other risk factors for silent cerebral infarction in the general population

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7 January 2021

Smoking and risk of hemorrhagic stroke in women

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7 January 2021

Smoking and the risk of hemorrhagic stroke in men

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7 January 2021

The protective effect of moderate alcohol consumption on ischemic stroke

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7 January 2021

Alcohol consumption and risk of stroke: a meta-analysis

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7 January 2021

Alcohol consumption and mortality: modelling risks for men and women at different ages

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7 January 2021

Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Genetic liability in stroke: a long-term follow-up study of Danish twins.

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7 January 2021

New advances in identifying genetic anomalies in stroke-prone probands

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Localization of a susceptibility gene for common forms of stroke to 5q12

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The gene encoding phosphodiesterase 4D confers risk of ischemic stroke

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Ultrasonic-pathological comparison of the human arterial wall. Verification of intima-media thickness.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Reproducibility of in vivo carotid intima-media thickness measurements: a review

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Genetic and Environmental Contributions to Atherosclerosis Phenotypes in Men and Women

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Environmental and genetic determinants of intima-media thickness of the carotid artery

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Stromelysin-1 and Interleukin-6 Gene Promoter Polymorphisms Are Determinants of Asymptomatic Carotid Artery Atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Synergistic effect of -174 G/C polymorphism of the interleukin-6 gene promoter and 469 E/K polymorphism of the intercellular adhesion molecule-1 gene in Italian patients with history of ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Increased circulating malondialdehyde-modified LDL in the patients with familial combined hyperlipidemia and its relation with the hepatic lipase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Polymorphism of the apolipoprotein E gene and early carotid atherosclerosis defined by ultrasonography in asymptomatic adults

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Apolipoprotein E polymorphism is associated with segment-specific extracranial carotid artery intima-media thickening

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Effect of polymorphism of apolipoprotein E and angiotensin-converting enzyme genes on arterial wall thickness

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Apolipoprotein E4, lipoprotein lipase C447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness of carotid and femoral arteries in healthy subjects from the Stanislas cohort

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensin-converting enzyme gene polymorphism is associated with carotid arterial wall thickness in non-insulin-dependent diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Relationship of angiotensin-converting enzyme gene polymorphism to carotid wall thickness in middle-aged men

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensin-converting enzyme gene polymorphism and carotid wall thickening in a community population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Meta-analysis of the ACE gene in ischaemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Polymorphisms in the angiotensinogen gene are associated with carotid intimal–medial thickening in females from a community-based population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Left ventricular mass, carotid wall thickness, and angiotensinogen gene polymorphism in patients with hypertension.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Cardiovascular phenotype of young adults and angiotensinogen alleles

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensinogen mutations and risk for ischemic heart disease, myocardial infarction, and ischemic cerebrovascular disease. Six case-control studies from the Copenhagen City Heart Study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Relationship between high-density lipoprotein paraoxonase gene M/L55 polymorphism and carotid atherosclerosis differs in smoking and nonsmoking men.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Témoin de l'Infarctus du Myocarde

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B : European Atherosclerosis Research Study (EARS) II.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Apolipoprotein E Alleles and Risk of Coronary Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Haplotypes of angiotensinogen in essential hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Human serum paraoxonase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Cigarette smoke extract inhibits plasma paraoxonase activity by modification of the enzyme's free thiols

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Lack of association between carotid intima-media thickness and paraoxonase gene polymorphism in non-insulin dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol. Studies in normotriglyceridemia and moderate hypertriglyceridemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Organization of the human cholesteryl ester transfer protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels: role of Sp1/Sp3 in transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Heterogeneity at the CETP Gene Locus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

Prediction of Coronary Heart Disease Using Risk Factor Categories

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2804%2900708-2

7 January 2021

10.1016/S1474-4422(04)00708-2

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DOI

1 reference

9 August 2017

1 reference