(Q35708618)

9 August 2017

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title

Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention (English)

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9 August 2017

Dennis S Charney

1

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9 August 2017

Husseini K Manji

series ordinal

2

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9 August 2017

publication date

16 March 2004

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Science's STKE : signal transduction knowledge environment

9 August 2017

published in

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9 August 2017

volume

2004

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9 August 2017

issue

225

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9 August 2017

page(s)

re5

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Neurobiology of depression

9 August 2017

cites work

1 reference

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Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects

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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

21 January 2018

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Stressful life events and genetic liability to major depression: genetic control of exposure to the environment?

21 January 2018

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Signal transduction and genes-to-behaviors pathways in psychiatric diseases

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The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

21 January 2018

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The cellular neurobiology of depression

21 January 2018

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Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

21 January 2018

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Glial reduction in the subgenual prefrontal cortex in mood disorders

21 January 2018

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Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

21 January 2018

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Mind glue: implications of glial cell biology for psychiatry

21 January 2018

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Control of synapse number by glia

21 January 2018

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Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

21 January 2018

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Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion

21 January 2018

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Relapse of depression after rapid depletion of tryptophan.

21 January 2018

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PET imaging of serotonin 1A receptor binding in depression

21 January 2018

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Serotonin brain circuits involved in major depression and suicide

21 January 2018

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Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

21 January 2018

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Chronic social stress: effects on limbic brain structures

21 January 2018

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Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone

21 January 2018

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Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression

21 January 2018

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Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus

21 January 2018

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Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography

21 January 2018

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Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

21 January 2018

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Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

21 January 2018

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A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression

21 January 2018

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Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders

21 January 2018

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Stress and hippocampal plasticity

21 January 2018

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Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement.

21 January 2018

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Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain.

21 January 2018

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Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration.

21 January 2018

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Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease

21 January 2018

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Serum cortisol response to transsphenoidal surgery for Cushing disease

21 January 2018

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Future therapeutic targets in mood disorders: the glucocorticoid receptor

21 January 2018

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Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

21 January 2018

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Early life stress and inherited variation in monkey hippocampal volumes

21 January 2018

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Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

21 January 2018

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Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Neurogenesis in the adult human hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Regulation of hippocampal neurogenesis in adulthood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

More hippocampal neurons in adult mice living in an enriched environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

21 January 2018

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Restoring production of hippocampal neurons in old age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Repeated stress increases catalytic TrkB mRNA in rat hippocampus

21 January 2018

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21 January 2018

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Neurotrophins and neuronal plasticity

21 January 2018

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Intracellular signaling pathways activated by neurotrophic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

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Bcl-2 promotes regeneration of severed axons in mammalian CNS

21 January 2018

1 reference

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Why do mature CNS neurons of mammals fail to re-establish connections following injury--functions of bcl-2.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum.

21 January 2018

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CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2/N Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

The next generation of PDE4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Update on the therapeutic potential of PDE4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Survival signaling and selective neuroprotection through glutamatergic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Current perspectives on the development of non-biogenic amine-based antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Selective chronic stress-induced in vivo ERK1/2 hyperphosphorylation in medial prefrontocortical dendrites: implications for stress-related cortical pathology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Social stress exacerbates stroke outcome by suppressing Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Neural plasticity to stress and antidepressant treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Antidepressant-like effect of brain-derived neurotrophic factor (BDNF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Adult brain neurogenesis and psychiatry: a novel theory of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Antidepressants and neuroplasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Increased neurogenesis and brain‐derived neurotrophic factor in neurokinin‐1 receptor gene knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2252004RE5

21 January 2018

Identifiers

DOI

10.1126/STKE.2252004RE5

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9 August 2017

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