(Q35710032)

English

Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart.

scientific article published on 7 December 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

3

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18 January 2020

Sagartirtha Sarkar

6

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18 January 2020

author name string

Saiful Anam Mir

1

1 reference

Europe PubMed Central

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18 January 2020

Arunachal Chatterjee

2

1 reference

Europe PubMed Central

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18 January 2020

Kanchan Pathak

4

1 reference

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18 January 2020

Sushil K Mahata

5

1 reference

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18 January 2020

language of work or name

0 references

publication date

7 December 2011

1 reference

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18 January 2020

number of pages

12

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

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18 January 2020

287

1 reference

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18 January 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2666-2677

1 reference

Europe PubMed Central

PMC publication ID

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18 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3268425/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy

1 reference

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12 July 2018

TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Proinflammatory cytokines in heart failure: double-edged swords

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Molecular targets and regulators of cardiac hypertrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Connective tissue growth factor and cardiac fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Role of the JAK-STAT pathway in myocardial injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Angiotensin II and myocyte growth: role of fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Determination of hydroxyproline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

12 July 2018

Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac m

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

25 September 2018

IL-17 Eliminates the Therapeutic Effects of Myelin Basic Protein-Induced Nasal Tolerance in Experimental Autoimmune Encephalomyelitis by Activating IL-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268425

15 November 2018

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eccentric cardiac hypertrophy was induced by long-term intermittent hypoxia in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of myocytes in myocardial collagen production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging role of the JAK-STAT pathway as a mechanism of protection against ischemia/reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac hypertrophy in spontaneously hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased collagen synthesis and decreased collagen degradation in right ventricular hypertrophy induced by pressure overload

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arteriolar wall thickening, capillary rarefaction and interstitial fibrosis in the heart of rats with renal failure:the effects of ramipril, nifedipine and moxonidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3

1 reference

https://pubmed.ncbi.nlm.nih.gov/22157761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.246173

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22157761%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

ResearchGate publication ID

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