(Q35731654)

9 August 2017

title

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility (English)

1 reference

9 August 2017

author name string

Marie-Helene Larraufie

1

1 reference

9 August 2017

Wan Seok Yang

2

1 reference

9 August 2017

Elise Jiang

3

1 reference

9 August 2017

Ajit G Thomas

4

1 reference

9 August 2017

Barbara S Slusher

5

1 reference

9 August 2017

Brent R Stockwell

6

1 reference

9 August 2017

language of work or name

English

0 references

publication date

14 July 2015

1 reference

Bioorganic & Medicinal Chemistry Letters

9 August 2017

published in

1 reference

9 August 2017

volume

25

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9 August 2017

issue

21

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9 August 2017

page(s)

4787-4792

1 reference

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Regulation of ferroptotic cancer cell death by GPX4

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Drug discovery considerations in the development of covalent inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Irreversible inhibitors of c-Src kinase that target a nonconserved cysteine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Ferroptosis: an iron-dependent form of nonapoptotic cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Discovery of Potent and Selective Covalent Inhibitors of JNK

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

The resurgence of covalent drugs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Large shifts in pKa values of lysine residues buried inside a protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

A structure-guided approach to creating covalent FGFR inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Aldehyde metabolism in the cardiovascular system.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Reversible covalent inhibition of a protein target.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653046

Synthesis and SAR study of novel peptide aldehydes as inhibitors of 20S proteasome

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26231156

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2015.07.018

1 reference

9 August 2017

1 reference

9 August 2017

1 reference