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Bile Acids as Hormones: The FXR-FGF15/19 Pathway
scientific article published on 27 May 2015
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scholarly article
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Europe PubMed Central
PMC publication ID
4465534
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
review article
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title
Bile Acids as Hormones: The FXR-FGF15/19 Pathway
(English)
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Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
author
David Mangelsdorf
series ordinal
2
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Europe PubMed Central
PMC publication ID
4465534
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
author name string
Steven A Kliewer
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1
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Europe PubMed Central
PMC publication ID
4465534
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
publication date
27 May 2015
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Europe PubMed Central
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4465534
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16 February 2020
published in
Digestive Diseases
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PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
volume
33
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Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
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16 February 2020
issue
3
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Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
page(s)
327-331
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Europe PubMed Central
PMC publication ID
4465534
reference URL
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16 February 2020
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Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
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The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
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Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
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12 July 2018
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
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Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
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12 July 2018
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
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Bile acids: natural ligands for an orphan nuclear receptor
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12 July 2018
Identification of a nuclear receptor for bile acids
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12 July 2018
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
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12 July 2018
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1.
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12 July 2018
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter
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12 July 2018
Identification of a nuclear receptor that is activated by farnesol metabolites
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12 July 2018
A nontumorigenic variant of FGF19 treats cholestatic liver diseases.
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25 September 2018
Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.
1 reference
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25 September 2018
Identification of a hormonal basis for gallbladder filling.
1 reference
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25 September 2018
Redundant pathways for negative feedback regulation of bile acid production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4465534
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25 September 2018
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4465534
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25 September 2018
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4465534
retrieved
25 September 2018
Identifiers
DOI
10.1159/000371670
1 reference
stated in
Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PMC publication ID
4465534
1 reference
stated in
Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
PubMed publication ID
26045265
1 reference
stated in
Europe PubMed Central
PMC publication ID
4465534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26045265%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 February 2020
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