(Q35747885)

10 August 2017

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title

Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders (English)

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10 August 2017

Teruo Hayashi

1

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PubMed ID

15089113

10 August 2017

Tsung-Ping Su

series ordinal

2

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10 August 2017

1 January 2004

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10 August 2017

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10 August 2017

18

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10 August 2017

269-284

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10 August 2017

5

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https://scigraph.springernature.com/pub.10.2165/00023210-200418050-00001

10 August 2017

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cites work

Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor

1 reference

12 December 2020

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine

1 reference

12 December 2020

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.

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12 December 2020

Neuropharmacology of St. John's Wort (Hypericum)

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12 December 2020

Evidence for a multi-site model of the rat brain sigma receptor

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12 December 2020

Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain

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12 December 2020

Does sigma receptor antagonism predict clinical antipsychotic efficacy?

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12 December 2020

Molecular mechanisms that underlie structural and functional changes at the postsynaptic membrane during synaptic plasticity

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12 December 2020

Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor

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12 December 2020

Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial.

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12 December 2020

Polymorphisms of the sigma(1) receptor gene in schizophrenia: An association study

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12 December 2020

Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns.

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12 December 2020

Cocaine binding at sigma receptors.

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12 December 2020

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions

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12 December 2020

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine

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12 December 2020

Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor

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12 December 2020

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test

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12 December 2020

Schizophrenia and glutamatergic transmission

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12 December 2020

Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons.

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12 December 2020

MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells

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12 December 2020

Evidence for a role of haloperidol-sensitive sigma-'opiate' receptors in the motor effects of antipsychotic drugs

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12 December 2020

N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice

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12 December 2020

Neurosteroids in depression: a review

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12 December 2020

MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain

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12 December 2020

Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

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12 December 2020

Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase.

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12 December 2020

Stereoisomers of N -Allylnormetazocine: Phencyclidine-Like Behavioral Effects in Squirrel Monkeys and Rats

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12 December 2020

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog

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12 December 2020

Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands

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12 December 2020

Effects of estrogen on memory function in surgically menopausal women

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12 December 2020

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors

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12 December 2020

Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels

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12 December 2020

Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons

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12 December 2020

(+)-[3H]SKF 10,047, (+)-[3H]ethylketocyclazocine, mu, kappa, delta and phencyclidine binding sites in guinea pig brain membranes.

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12 December 2020

Modulation of neuronal activities in the central nervous system via sigma receptors

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12 December 2020

PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

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12 December 2020

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

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12 December 2020

Correlation between neuroleptic binding to sigma(1) and sigma(2) receptors and acute dystonic reactions

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12 December 2020

Efficacy and safety of an opiate sigma-receptor antagonist (SL 82.0715) in schizophrenic patients with negative symptoms: an open dose-range study.

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12 December 2020

Open clinical trial on the sigma ligand panamesine in patients with schizophrenia

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12 December 2020

Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade

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12 December 2020

Selective antagonism of opioid analgesia by a sigma system

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12 December 2020

Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.

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12 December 2020

Dehydroepiandrosterone (DHEA) treatment of depression

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12 December 2020

BMY 14802, a sigma receptor ligand for the treatment of schizophrenia

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12 December 2020

Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved

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12 December 2020

Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex

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12 December 2020

Cognitive function in nondemented older women who took estrogen after menopause.

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12 December 2020

Dehydroepiandrosterone: antiglucocorticoid action in mice

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12 December 2020

Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons

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12 December 2020

Sigma receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP.

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12 December 2020

Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment

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12 December 2020

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

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12 December 2020

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.

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12 December 2020

Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding

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12 December 2020

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

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12 December 2020

Neurosteroid metabolism in the human brain

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12 December 2020

Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C.

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12 December 2020

Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants

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12 December 2020

Occupancy of striatal D(2)-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic.

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12 December 2020

sigma Receptor antagonists block the development of sensitization to cocaine.

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12 December 2020

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides

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12 December 2020

Role of (+)-SKF-10,047-sensitive sub-population of sigma 1 receptors in amelioration of conditioned fear stress in rats: association with mesolimbic dopaminergic systems.

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12 December 2020

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

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12 December 2020

Prevention of nimodipine-induced impairment of learning by the selective sigma ligand PRE-084

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12 December 2020

Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function

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12 December 2020

Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands

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12 December 2020

σ-1 Receptors (σ1Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

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12 December 2020

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

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12 December 2020

Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice

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12 December 2020

Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain.

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12 December 2020

Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?

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12 December 2020

Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain

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12 December 2020

Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study.

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12 December 2020

Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test

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12 December 2020

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus

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12 December 2020

Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors

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12 December 2020

Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors

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12 December 2020

Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

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12 December 2020

The antidepressant-like effect induced by the sigma(1) (sigma(1)) receptor agonist igmesine involves modulation of intracellular calcium mobilization.

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12 December 2020

Acute organic psychosis due to Talwin (pentazocine)

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12 December 2020

A proposal for the classification of sigma binding sites

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12 December 2020

Analysis of neurosteroid levels in attention deficit hyperactivity disorder

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12 December 2020

Decrease in sigma but no increase in striatal dopamine D4 sites in schizophrenic brains

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12 December 2020

The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

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12 December 2020

Some of the effects of the selective sigma ligand (+)pentazocine are mediated via a naloxone-sensitive receptor

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12 December 2020

Neurobiology of depression

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12 December 2020

Pentazocine and tripelennamine: a drug abuse epidemic?

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12 December 2020

Sigma receptors in schizophrenic cerebral cortices

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12 December 2020

Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors

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12 December 2020

Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

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12 December 2020

Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia

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12 December 2020

Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM).

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12 December 2020

Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.

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12 December 2020

Intracellular Dynamics of σ-1 Receptors (σ1Binding Sites) in NG108-15 Cells

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12 December 2020

The cholinergic synapse and the site of memory

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12 December 2020

Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary

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12 December 2020

The sigma receptor as a ligand-regulated auxiliary potassium channel subunit

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12 December 2020

Adrenal androgens and cortisol in major depression

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12 December 2020

Pentazocine psychosis: a case of persistent delusions

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12 December 2020

Methamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia

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12 December 2020

Neurosteroids: beginning of the story

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12 December 2020

Purification, molecular cloning, and expression of the mammalian sigma1-binding site

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12 December 2020

Regulating ankyrin dynamics: Roles of sigma-1 receptors

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12 December 2020

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain

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12 December 2020

Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin-releasing factor-induced inhibition of gastric acid secretion in rats

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12 December 2020

Uncompetitive inhibition of [3H]1,3-di-o-tolyl-guanidine-defined sigma binding sites by desipramine, propranolol and alprenolol in rat brain.

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12 December 2020

Cloning and functional characterization of a sigma receptor from rat brain.

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12 December 2020

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

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12 December 2020

Sigma1 receptor modulation of opioid analgesia in the mouse

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12 December 2020

Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors

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12 December 2020

Long-term synaptic potentiation

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12 December 2020

Ameliorating effects of sigma receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system.

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12 December 2020

Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens

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12 December 2020

Neurosteroids: a novel function of the brain.

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12 December 2020

Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration

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12 December 2020

The cellular neurobiology of depression

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12 December 2020

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.

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12 December 2020

Involvement of sigma 1 receptors in methamphetamine-induced behavioral sensitization in rats.

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12 December 2020

Phencyclidine and dizocilpine modulate dopamine release from rat nucleus accumbens via sigma receptors

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12 December 2020

Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction

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12 December 2020

Antidepressant drugs appear to enhance cocaine-induced toxicity

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12 December 2020

[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes.

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12 December 2020

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors

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12 December 2020

Naloxone-sensitive, haloperidol-sensitive, [3H](+)SKF-10047-binding protein partially purified from rat liver and rat brain membranes: an opioid/sigma receptor?

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12 December 2020

Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site

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12 December 2020

Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss

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12 December 2020

Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.

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12 December 2020

10.2165/00023210-200418050-00001

Identifiers

DOI

1 reference

PubMed ID

15089113

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15089113