(Q35767632)

10 August 2017

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title

The 2P-domain K+ channels: role in apoptosis and tumorigenesis (English)

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10 August 2017

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Amanda J Patel

1

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PubMed ID

15133669

10 August 2017

Michel Lazdunski

series ordinal

2

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10 August 2017

5 May 2004

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10 August 2017

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10 August 2017

448

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10 August 2017

261-273

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10 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s00424-004-1255-8

10 August 2017

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cites work

Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.

1 reference

12 December 2020

Oncogenic potential of EAG K(+) channels

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12 December 2020

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

1 reference

12 December 2020

TASK-5, a novel member of the tandem pore K+ channel family

1 reference

12 December 2020

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture.

1 reference

12 December 2020

TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family

1 reference

12 December 2020

TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor

1 reference

12 December 2020

K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus

1 reference

12 December 2020

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium

1 reference

12 December 2020

TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons

1 reference

12 December 2020

Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K(+) channel

1 reference

12 December 2020

An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum

1 reference

12 December 2020

TASK, a human background K+ channel to sense external pH variations near physiological pH

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12 December 2020

Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5

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12 December 2020

Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance

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12 December 2020

An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells

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12 December 2020

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK

1 reference

12 December 2020

TASK-1 is a highly modulated pH-sensitive 'leak' K(+) channel expressed in brainstem respiratory neurons

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12 December 2020

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

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12 December 2020

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels

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12 December 2020

Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits.

1 reference

12 December 2020

Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells.

1 reference

12 December 2020

TASK-3, a new member of the tandem pore K(+) channel family

1 reference

12 December 2020

Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors

1 reference

12 December 2020

Mediation of neuronal apoptosis by enhancement of outward potassium current.

1 reference

12 December 2020

Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments

1 reference

12 December 2020

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel

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12 December 2020

Synapse-independent and synapse-dependent apoptosis of cerebellar granule cells in postnatal rabbits occur at two subsequent but partly overlapping developmental stages

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12 December 2020

Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3

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12 December 2020

Control of cell proliferation by cell volume alterations in rat C6 glioma cells.

1 reference

12 December 2020

Evidence for an early G1 ionic event necessary for cell cycle progression and survival in the MCF-7 human breast carcinoma cell line

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12 December 2020

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel

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12 December 2020

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

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12 December 2020

Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms

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12 December 2020

Keratinocyte K+ channels mediate Ca2+-induced differentiation

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12 December 2020

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals

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12 December 2020

Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle

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12 December 2020

Inhibition of TASK-1 potassium channel by phospholipase C.

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12 December 2020

Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3

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12 December 2020

Effect of specific ion channel blockers on cultured Schwann cell proliferation

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12 December 2020

Characterization of four types of background potassium channels in rat cerebellar granule neurons

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12 December 2020

NMDA receptor-mediated K+ efflux and neuronal apoptosis.

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12 December 2020

Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney

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12 December 2020

Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels

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12 December 2020

Inhalational anesthetics activate two-pore-domain background K+ channels

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12 December 2020

THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels

1 reference

12 December 2020

Combined antisense and pharmacological approaches implicate hTASK as an airway O(2) sensing K(+) channel

1 reference

12 December 2020

Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel

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12 December 2020

Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2

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12 December 2020

Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.

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12 December 2020

Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation.

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12 December 2020

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function

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12 December 2020

Potassium channels and regulation of proliferation of human melanoma cells

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12 December 2020

An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1.

1 reference

12 December 2020

Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali

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12 December 2020

K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation.

1 reference

12 December 2020

Potential identification of the O2-sensitive K+ current in a human neuroepithelial body-derived cell line

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12 December 2020

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

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12 December 2020

1 reference

12 December 2020

p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1

1 reference

12 December 2020

A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons

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12 December 2020

Lipid and mechano-gated 2P domain K(+) channels.

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12 December 2020

Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume

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12 December 2020

1 reference

12 December 2020

Blockage of voltage-gated K+ channels inhibits adhesion and proliferation of hepatocarcinoma cells

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12 December 2020

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure

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12 December 2020

Calcium-cell cycle regulator, differentiator, killer, chemopreventor, and maybe, tumor promoter.

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12 December 2020

ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons.

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12 December 2020

Recombinant hTASK1 is an O(2)-sensitive K(+) channel

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12 December 2020

Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.

1 reference

12 December 2020

Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel

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12 December 2020

K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart

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12 December 2020

A mammalian two pore domain mechano-gated S-like K+ channel

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12 December 2020

Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels

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12 December 2020

The role of calcium in the cell cycle: facts and hypotheses

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12 December 2020

Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.

1 reference

12 December 2020

Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells.

1 reference

12 December 2020

A novel oxygen-sensitive potassium current in rat carotid body type I cells.

1 reference

12 December 2020

Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney

1 reference

12 December 2020

TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family

1 reference

12 December 2020

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation

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12 December 2020

Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells

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12 December 2020

Properties and modulation of mammalian 2P domain K+ channels.

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12 December 2020

The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.

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12 December 2020

Cns distribution of members of the two-pore-domain (KCNK) potassium channel family.

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12 December 2020

Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system

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12 December 2020

Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family

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12 December 2020

Regulation and critical role of potassium homeostasis in apoptosis

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12 December 2020

The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons.

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12 December 2020

Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis

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12 December 2020

TRAAK is a mammalian neuronal mechano-gated K+ channel.

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12 December 2020

TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission

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12 December 2020

A non-inactivating K+ current sensitive to muscarinic receptor activation in rat cultured cerebellar granule neurons.

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12 December 2020

Two-pore domain K+ channels-molecular sensors

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12 December 2020

Diversity in the mechanisms of neuronal cell death.

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12 December 2020

Ions, cell volume, and apoptosis

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12 December 2020

Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel

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12 December 2020

TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure

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12 December 2020

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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12 December 2020

Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action

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12 December 2020

Mitogenic signal transduction in human breast cancer cells

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12 December 2020

Potassium conductance in the androgen-sensitive prostate cancer cell line, LNCaP: involvement in cell proliferation

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12 December 2020

Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor

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12 December 2020

Intracellular K+ suppresses the activation of apoptosis in lymphocytes

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12 December 2020

Representational difference analysis: finding the differences between genomes

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12 December 2020

Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits.

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12 December 2020

TREK-1 is a heat-activated background K(+) channel

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12 December 2020

Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1).

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12 December 2020

K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels.

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12 December 2020

Potassium channels, proliferation and G1 progression

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12 December 2020

Apoptosis, cell volume regulation and volume-regulatory chloride channels

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12 December 2020

Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules.

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12 December 2020

Two-pore-Domain (KCNK) potassium channels: dynamic roles in neuronal function

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12 December 2020

Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi.

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12 December 2020

TWIK-2, an inactivating 2P domain K+ channel

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12 December 2020

Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells

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12 December 2020

TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells.

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12 December 2020

Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation

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12 December 2020

A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal Cord

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12 December 2020

Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance.

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12 December 2020

Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2

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12 December 2020

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.

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12 December 2020

Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem

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12 December 2020

The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.

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12 December 2020

Calcium, protease action, and the regulation of the cell cycle.

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12 December 2020

Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection

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12 December 2020

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge

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12 December 2020

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

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12 December 2020

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

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12 December 2020

KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.

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12 December 2020

Molecular and functional properties of two-pore-domain potassium channels.

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12 December 2020

10.1007/S00424-004-1255-8

Identifiers

DOI

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10 August 2017

1 reference

PubMed ID

15133669